Arterial blood gas and acid‑base balance in patients with pregnancy‑induced hypertension syndrome

Abstract

This study aimed to investigate the expression of arterial blood gas and acid-base balance in patients with pregnancy-induced hypertension syndrome and their influence on newborns. A total of 348 patients with pregnancy-induced hypertension syndrome (research group) admitted and treated in the First People's Hospital of Jining from March 2013 to March 2016 were retrospectively analyzed, and another 156 cases of healthy pregnant women who were physically examined were selected as the control group. Blood gas analysis was performed on pregnant women, and pH value, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate radical (HCO3−) and base excess (BE) were included as test indexes. Apgar score was made for newborns for neonatal asphyxia. The evaluation was performed at 1, 5, and 10 min after birth to analyze the correlation between the maternal arterial blood pH and the neonatal Apgar score. The pH value, and PO2 and HCO3− levels in the research group were lower than those in the control group (p<0.05). PCO2 and BE levels in the research group were higher than those in the control group (p<0.05). The incidence of neonatal mild asphyxia (Apgar score, 4–6 points) and neonatal severe asphyxia (Apgar score, <4 points) in the research group were higher than that in the control group (p<0.05). The Apgar score of newborns was positively correlated with the pH value of the arterial blood of pregnant women. Blood gas analysis in patients with pregnancy-induced hypertension syndrome is useful to a certain extent to evaluate the condition of the patient. The combination of the pH value of the patient and the Apgar score of the newborns may help improve the judgement rate of neonatal asphyxia so as to improve the quality of childbirth by early monitoring and intervention of the newborns.

Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution

“…The acid-base balance was examined by measuring the pH, base excess (BE), bicarbonate ion concentration (HCO 3 − ) [ 22 ], and blood lactate concentration (Lac) to assess the tissue hypoxia of rats together with the blood gas parameters. The pH in the HES200 group was increased significantly at 60 min compared with BL and H3 ( P < 0.01, Fig.…”

Diagnostic and Prognostic Value of Deregulated Long Non-Coding RNA Plasmacytoma Variant Translocation 1 in Patients with Gestational Hypertension

“…HDP is a special disease occurring during pregnancy, mainly characterized by edema, proteinuria, and hypertension (Hansson et al 2014). In severe cases, diffuse intravascular coagulation, placental abruption, heart failure, cerebral hemorrhage, coma, convulsion and even death may occur (Cao et al 2019). At present, the etiology and pathogenesis of HDP have not been clearly defined, and its diagnosis depends on clinical manifestations and laboratory indicators.…”

Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin

“…Overall, our results had shown that uptake of pravastatin by OATP1A2 occurs at physiological pH in vitro, which suggests that this transporter could contribute to the placental uptake of pravastatin. Cao et al, 2019 reported a decrease of maternal arterial blood pH in cases of pregnancy-induced hypertension 47 ; and gestational hypertension can be complicated with preeclampsia in up to 50% of the affected women. 48 Thus, a shift in the pH microenvironment of the maternal-placental interface towards acidification in preeclampsia 49 can affect the activity of OATP1A2-mediated uptake of the drug, as the function of this transporter is sensitive to pH.…”