Arterial chemoradiotherapy for carcinomas of the external auditory canal and middle ear

Yamamoto, Satoshi; Doi, Hiroshi; Takada, Yasuhiro; Odawara, Soichi; Niwa, Yasue; Ishikura, Reiichi; Kamikonya, Norihiko; Terada, Tomonori; Uwa, Nobuhiro; Sagawa, Kosuke; Hirota, Shun

doi:10.1002/lary.24908

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…Recently, carbon ion radiotherapy and arterial chemoradiotherapy have been reported to be effective and safe for locally advanced SCC of the external and middle ear. 14 , 15) However, those modalities may be insufficient if used alone; for example, the 3-year overall survival in patients who received carbon ion radiotherapy was 41.6%, 14) and the 2-year overall survival in patients who received arterial chemoradiotherapy was 58.7%. 4) Given the present and previous findings, we recommend that surgery-based combination therapy be conducted.…”

Section: Discussionmentioning

confidence: 99%

Treatment and Outcomes of Carcinoma of the External and Middle Ear: The Validity of En Bloc Resection for Advanced Tumor

Matoba

Hanai

Suzuki

et al. 2018

Neurol. Med. Chir.(Tokyo)

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Carcinoma of the external and middle ear is a very rare disease. Despite the various treatment modalities available, its prognosis is still poor. We aimed to analyze the treatment modalities, outcomes, and validity of surgical approaches, especially in advanced tumors in the ear. Twenty-five patients with carcinoma of the external and middle ear were retrospectively analyzed. The modified Pittsburgh staging system was used for staging of the patients. Overall and disease-free survival was estimated using of Kaplan-Meier method. In our cohort of 25 patients, the majority (76%) had tumor located in external auditory meatus. The most common histologic subtype was squamous cell carcinoma (80%). More than half of patients (56%) had tumor stage IV. In the stage IV group, five patients underwent subtotal temporal bone resection and ipsilateral neck dissection. Seven patients underwent definitive radiotherapy. The remaining two patients underwent palliative chemotherapy. The 2-year overall and disease-free survival for patients with tumor stage IV was 67.7% and 57.8%, respectively. In patients with tumor stage IV, the 2-year overall survival for patients who underwent surgery was 80.0% versus 53.6% for those who underwent radiotherapy (P = 0.16). The 2-year disease-free survival for patients who underwent surgery was 80.0% versus 28.6% for those who underwent radiotherapy (P = 0.15). In the present study, the outcome of patients who received surgical treatment tended to be better than that of patients who received radiation therapy. Our results suggest that en bloc resection could be the first choice even in the advanced disease stage.

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Section: Discussionmentioning

confidence: 99%

Treatment and Outcomes of Carcinoma of the External and Middle Ear: The Validity of En Bloc Resection for Advanced Tumor

Matoba

Hanai

Suzuki

et al. 2018

Neurol. Med. Chir.(Tokyo)

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“…Regardless of the origin of the primary cancer, combined surgery and radiotherapy remains the treatment of choice for the majority of these malignancies [ 7 ]. However, the effectiveness of preoperative chemoradiotherapy [ 8 ], of arterial chemotherapy [ 9 ], of the employment of carbon ion radiotherapy [ 10 ], and of radical radiation therapy (RT), comprising intracavitary brachytherapy as a boost after external beam RT [ 11 ], suggests new perspectives are needed in TB cancer treatment. Though there are advances in modern imaging and irradiation, this rare and difficult clinical entity is still a challenge for the surgeons, thus only a finite number of departments deal with this type of surgery.…”

Section: Introductionmentioning

confidence: 99%

Multicenter experiences in temporal bone cancer surgery based on 89 cases

Wierzbicka¹,

Niemczyk

Bruzgielewicz

et al. 2017

PLoS ONE

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ObjectiveTo present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers.Study designRetrospective case review.SettingFour tertiary referral centers.Material89 patients with cancer of the temporal bone treated between January 2006 and December 2010.InterventionMultidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy.Main outcome measureDisease-specific survival, overall survival.ResultsIn 27.0% of the patients, relapse was reported, with an average of 6.3 months after surgery; 31 patients (34.8%) died during the follow-up. The average mortality was 22.1 months. Fifty-four patients (58.7%) stayed alive during the time of observation. The average survival time was 42.0 months. The median time of survival with relapse was 12 months (range: 1–51 months). The three-year disease-free rate was 38.0% and the overall survival rate was 58.7%.ConclusionsPetrosectomy is an effective treatment for malignant temporal bone invasion. The probability of a good outcome was statistically decreased with a high T grade, positive margins, and salvage surgery. Younger age is connected with better prognosis. One of the major tasks remains to improve detection and to shorten the time to diagnosis, keeping in mind that symptoms are insidious and in younger people, the time before diagnosis was longer.

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“…Nagano et al reported that the DCF regimen was potentially the most effective method, with reference to their study that revealed a 100% 2-year OS and locoregional control rate in six patients with advanced EACC who had received this regimen (23). Other studies supported the use of an intra-arterial cisplatin infusion in combination with radiotherapy for locally advanced cases of EACC (24,25). Several limitations existed in our study.…”

Section: Discussionmentioning

confidence: 79%

A retrospective analysis of radiotherapy in the treatment of external auditory canal carcinoma

et al. 2021

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Arterial chemoradiotherapy for carcinomas of the external auditory canal and middle ear

Abstract: These results suggest that superselective arterial chemoradiation can be a treatment option for locally advanced carcinomas of the external auditory canal and middle ear.

Cited by 13 publications

References 21 publications

Treatment and Outcomes of Carcinoma of the External and Middle Ear: The Validity of En Bloc Resection for Advanced Tumor

Treatment and Outcomes of Carcinoma of the External and Middle Ear: The Validity of En Bloc Resection for Advanced Tumor

Multicenter experiences in temporal bone cancer surgery based on 89 cases

A retrospective analysis of radiotherapy in the treatment of external auditory canal carcinoma

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