Arterial Hypertension Associated With Hyperuricemia: Features of Heart Damage

Abstract

The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) – arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation. We used clinical, anthropometric, biochemical, instrumental, statistical method. Serum uric acid level was observed by the reaction with uricase. Left ventricular mass index was calculated as left ventricular mass to body surface area ratio. The results were analyzed statistically by SPSS 21 and Graphpad. Results: Left ventricular mass index was significantly higher (р = 0,0498) in patients from the І group (109,7 ± 3,21) g/m2 comparable with the ІІ (97,6 ± 5,35) g/m2 and increased in proportion to the biggest level of uric acid (r = 0,31; p = 0,04) in patients with arterial hypertension and hyperuricemia. Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension.

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

“…It has been observed that both albuminuria and LVH have a higher risk of associated HU. This is important because both lesions are closely linked with HTN [33,40,41], but also in patients with metabolic disorders such as obesity and DM [42,43]. Something similar happens to those CVD cases associated with a higher risk of HU, such as AFIB and HF, both directly related to HTN [44].…”

Hyperuricemia-Induced Acute Kidney Injury in the Context of Chronic Kidney Disease: A Case Report

“…Epidemiological and experimental evidence supports the idea that elevated serum urate concentrations contribute to gout, kidney disease, hypertension, and diabetes. [5] Gout is a metabolic disorder that is the most common manifestation of hyperuricemia. In this case, the patient's gout was diagnosed 5 years ago, which is a conceivable risk factor and the cause of repeated episodes of hyperuricemia.…”

“…[9] Experimental studies have also confirmed the role of urate in animal models of AKI. [5,10] The pathogenesis of AKI caused by hyperuricemia involves both crystal-independent and crystal-dependent mechanisms.…”

“…[19] Thus, no routine treatment for hyperuricemia in patients with preexisting kidney disease is recommended at present. [5]…”

“…[4] Classically, crystal-associated AKI usually develops from tumor lysis syndrome due to renal tubular obstruction. [5] In addition, the majority of studies report a relationship between serum uric acid (UA) levels and the devel-opment of AKI in various conditions such as cardiovascular (CV), hematology, infectious disease, gastrointestinal, and respiratory disorders. [3] Herein, we report a case of hyperuricemia-induced AKI via a crystal-dependent mechanism in the setting of chronic kidney disease (CKD) instead of the abovementioned conditions.…”