Arterial ¹⁸F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-Induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions

Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II

“…25 We recently showed that arterial 18 F-FDG uptake reflects TF expression and vascular thrombogenicity in rabbits. 9 These lines of evidence and the present results suggest that arterial glucose metabolism reflects the thrombogenicity of coronary atherosclerotic plaques. Because more cells were immunopositive for HK-II than for Glut-1 and this correlated with coronary thrombus formation, HK-II expression might be a marker of coronary plaque thrombogenicity.…”

“…7, 8 We recently found that arterial 18 F-FDG uptake reflects TF expression and vascular thrombogenicity in rabbits. 9 This implies an association between arterial glucose metabolism and vascular thrombogenicity.…”

Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging

“…While triggering often provoked the formation of adherent thrombi, these sites rarely displayed plaque rupture characterized by a disrupted fibrous cap, a potential difference with human atherothrombosis, although plaque rupture has been previously described following this pharmacologic triggering procedure. 45–47 On the other hand, this finding of mural thrombosis at sites of defective endothelial barrier function enhances the relevance of the present findings to superficial erosion, an increasingly recognized cause of acute coronary syndromes. These results further agree with the findings on thrombosed lesions observed in myocardial infarction-prone atherosclerotic rabbits treated with a spasmogenic triggering regimen.…”

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

“…We found that PAI-1 protein levels are closely associated with metabolic pathways in macrophages (Table S4). Furthermore, we recently demonstrated that 18 F-FDG uptake reflect nuclear factor-κB activation, tissue factor, an initiator of coagulation cascade, expression, and arterial thrombus formation in rabbits [42]. These findings suggest a link between vascular metabolism and thrombogenic potential of atherosclerotic artery.…”