Arterial Occlusion from Anti-Jo1 Antibody-associated Autoimmune Myositis: Arteritis not Compartment Syndrome

Laugharne, Matthew; Wood, James; Mitchell, David C.; Glover, S. C.

doi:10.1016/j.ejvsextra.2006.10.004

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…1 ASS can overlap with SSc; LETTER TO THE EDITOR however, eight ASS patients with SDI who did not exhibit SSc have been reported. [1][2][3][4][5] Of these, two patients did not have RP, 4,5 like our patient. In addition, our patient did not show nailfold capillary changes, which are also commonly seen in SSc.…”

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 69%

“…In seven cases, digital ulcers were limited to the fingertips, [1][2][3]5 but gangrene developed on the toes in one case. 4 However, the possibility of arteriosclerosis obliterans could not be ruled out in this case. 4 Our case appears to be the first in whom SDI was present on both the hands and feet, but RP and nailfold capillary changes were absent.…”

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 77%

“…4 However, the possibility of arteriosclerosis obliterans could not be ruled out in this case. 4 Our case appears to be the first in whom SDI was present on both the hands and feet, but RP and nailfold capillary changes were absent.…”

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 77%

“…These findings further support the idea that SDI in ASS may occur as a result of microcirculatory arteritis, which may lead to occlusive vasculopathy. 1,[3][4][5]…”

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 99%

See 3 more Smart Citations

Multiple digital ulcers on the hands and feet in anti‐PL‐12 antibody‐positive anti‐synthetase syndrome without Raynaud’s phenomenon

Hattori

Miyagawa

Mitsui

et al. 2021

The Journal of Dermatology

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Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 69%

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 77%

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 77%

“…These findings further support the idea that SDI in ASS may occur as a result of microcirculatory arteritis, which may lead to occlusive vasculopathy. 1,[3][4][5]…”

Section: Multiple Digital Ulcers On the Hands And Feet In Anti-pl-12 ...mentioning

confidence: 99%

See 2 more Smart Citations

Multiple digital ulcers on the hands and feet in anti‐PL‐12 antibody‐positive anti‐synthetase syndrome without Raynaud’s phenomenon

Hattori

Miyagawa

Mitsui

et al. 2021

The Journal of Dermatology

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The clinical characteristics and predictors of severe digital ischemia in patients with anti‐aminoacyl transfer RNA synthetase antibodies

Suma

Yoshida

Sugimoto

et al. 2021

The Journal of Dermatology

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Severe digital ischemia (SDI), which presents with digital ulcers, necrosis, or gangrene, has been reported to be a rare manifestation of anti‐aminoacyl transfer RNA synthetase (ARS) antibody‐positive polymyositis/dermatomyositis or anti‐synthetase syndrome. A retrospective study was conducted between 2009 and 2020 at our department to investigate the clinical features of anti‐ARS antibody‐positive patients with SDI and identify their predictors. A total of 46 patients who were positive for anti‐ARS antibody were included, four of whom (8.7%) presented with SDI. The characteristics of the patients with SDI were as follows: the median age was 74 years, with 75% being female; anti‐Jo–1 antibody, Raynaud's phenomenon, interstitial lung disease, and myositis were observed in two (50%), four (100%), four (100%), and three patients (75%), respectively. Next, we reviewed the literature of anti‐ARS antibody‐positive patients with SDI and investigated the predictors of SDI by analyzing a total of 51 patients, including the previously reported five patients with SDI. Multivariable analyses revealed that Raynaud's phenomenon and myositis independently predicted the development of SDI in patients with anti‐ARS antibody. In conclusion, digital ulcers, necrosis, or gangrene seem to be more common presentations in our study, and Raynaud's phenomenon and myositis can predict the complications of SDI in anti‐ARS antibody‐positive patients.

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Severe digital ischemia as an unrecognized manifestation in patients with antisynthetase autoantibodies: Case series and systematic literature review

Yoshida

Gono

Okazaki

et al. 2022

Journal of Scleroderma and Related Disorders

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Objective: Severe digital ischemia, including digital ulcers and gangrene, is considered rare in patients with antisynthetase antibodies. This study aimed to elucidate the clinical features of antisynthetase-positive patients complicated with digital ulcers and/or gangrene using a systematic literature review and case series in a single-center cohort. Methods: A systematic literature review was conducted to identify reports describing antisynthetase-positive cases with digital ulcers and/or gangrene. Our cohort of consecutive patients with antisynthetase antibodies was stratified by the history of severe digital ischemia. Demographic and clinical features and outcomes in patients with severe digital ischemia identified in the systematic literature review and our cohort were compared with those in patients without severe digital ischemia in our cohort. Results: The systematic literature review revealed 12 antisynthetase-positive patients with severe digital ischemia from one case series and eight case reports. Seven (7%) of 100 patients with antisynthetase antibodies in our cohort had a record of severe digital ischemia. Severe digital ischemia was often found at presentation and was associated with the classification of systemic sclerosis with or without myositis overlap. Clinical features associated with severe digital ischemia in antisynthetase-positive patients included Raynaud’s phenomenon ( p < 0.001), digital pitting scars ( p = 0.001), and nailfold capillary abnormality ( p = 0.02). Outcomes of severe digital ischemia were generally favorable with vasodilators. Conclusion: Severe digital ischemia is an overlooked complication in antisynthetase-positive patients. Antisynthetase antibodies should be measured in patients presenting with digital ulcers or gangrene, especially in those with systemic sclerosis phenotype and features associated with antisynthetase antibodies in the absence of systemic sclerosis-specific autoantibodies.

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Arterial Occlusion from Anti-Jo1 Antibody-associated Autoimmune Myositis: Arteritis not Compartment Syndrome

Cited by 3 publications

References 4 publications

Multiple digital ulcers on the hands and feet in anti‐PL‐12 antibody‐positive anti‐synthetase syndrome without Raynaud’s phenomenon

Multiple digital ulcers on the hands and feet in anti‐PL‐12 antibody‐positive anti‐synthetase syndrome without Raynaud’s phenomenon

The clinical characteristics and predictors of severe digital ischemia in patients with anti‐aminoacyl transfer RNA synthetase antibodies

Severe digital ischemia as an unrecognized manifestation in patients with antisynthetase autoantibodies: Case series and systematic literature review

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