Arterial Resistance in Late First Trimester as a Predictor of Subsequent Pregnancy-Related Hypertension

Kushtagi, Pralhad; Emani, Anoosha

doi:10.18295/squmj.2016.16.04.008

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Different analytical methods are used to measure the reference value. Several other studies also included ultrasound examinations with the presence of diastolic notch, Kushtagi & Emani, 2016 found 38 patients with diastolic notch diagnosed with preeclampsia from a total of 48 patients with preeclampsia, Vartun, Flo, Widnes, & Acharya, 2016 found 23 samples with diastolic notch from 27 samples [6], [7].…”

Section: Discussionmentioning

confidence: 99%

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

Lubis¹,

Hariman²,

Lumbanraja³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Reducing maternal mortality is one of the targets in the Millennium Development Goals (MDGs). In a systematic review, 4.6 per cent (95% CI 2.7-8.2) of pregnancies were complicated by preeclampsia worldwide. Preeclampsia occurs in around 10% of pregnancies in the world whereas developing countries contribute more than developed countries. In developing countries, there are 13 cases of preeclampsia in every 1,000 births, whereas in developed countries only 2-3 cases of preeclampsia are found in every 10,000 deliveries. Variations in prevalence among countries reflect, at least in part, differences in the distribution of maternal age and the proportion of nulliparous pregnant women in the population. AIM: We aimed to investigate the role of placental growth factor, soluble endoglin, and uterine artery diastolic notch to predict the early onset of preeclampsia. METHODS: This study used an analytical study with a nested case-control design. The study was conducted at Bunda Thamrin Hospital, Tanjung Mulia Mitra Medika Hospital, Sundari Hospital and a private clinic, from March to November 2018 with a total sample of 70 research subjects. RESULTS: Uterine artery diastolic notch was not found in 50% of subjects. A total of 27 subjects (38.6%) had a unilateral diastolic notch, and 8 subjects (11.4%) had a bilateral diastolic notch. Cut-off point PIGF levels was 441 pg/ml, and Area Under Curve (AUC) 82.5% (95% CI 61.5%-100%), with sensitivity 80% and specificity 87.7%. The levels sEng in this study could not predict the incidence of early-onset preeclampsia (p = 0.113). Combined PlGF and pulsatile index of uterine arteries may predict early onset preeclampsia with sensitivity 40% and specificity 90.77%. From these results, pregnant women o 22-24 weeks of pregnancy, the levels of PlGF and the uterine artery pulsatility index can be a predictor of early-onset preeclampsia. Examination of PlGF levels alone is sufficient as a predictor of early-onset preeclampsia. CONCLUSION: From these results, it can be concluded that in pregnant women of 22-24 weeks, the diastolic notches in uterine arteries cannot predict the incidence of early-onset preeclampsia. PlGF levels and pulsatile index of uterine arteries can be used as predictors of early-onset preeclampsia although examination of PlGF levels alone is sufficient as a predictor of early-onset preeclampsia.

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Section: Discussionmentioning

confidence: 99%

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

Lubis¹,

Hariman²,

Lumbanraja³

et al. 2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…From previous research studies also dominated by significant results that are in line with this study, which makes the initial step to do non-invasive screening. Previous research was in the form Kushtagi and Emani, 2016 with a p value of 0.013 but was carried out on samples with gestational hypertension, despite other studies by Vartun, Flo, Widnes, and Acharya,, Yu, Cui, Chen, and Chang and Narang, Agarwal, Das, Pandey, Agrawal, and Aliwith a very significant p value<0,0001 performed in pregnant women in the early trimester that ends in preeclampsia [34][35][36][37].…”

Section: Relationship Of Diastolic Notches Uterine Artery Pulsatile I...mentioning

confidence: 99%

The Role of Predictor Placental Growth Factor, Soluble Endoglin, Soluble-FMS-Like-Tyrosine Kinase-1 and Pulsatil Uterina Arterial Index to Predict the Early Onset of Preeclampsia

Lubis

2020

Int J Curr Pharm Sci

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Objective: In preeclampsia, there will be an increase in SFlt-1 and in and decrease in PlGF levels. This condition will cause disorders of vasculogenesis and angiogenesis in fetomaternal circulation, which will eventually lead to preeclampsia syndrome such as proteinuria, hypertension and endothelial dysfunction. Methods: An observational study design with nested case-control. The study was conducted at Bunda Thamrin Hospital, Tanjung Mulia Medika Hospital, Sundari Hospital and private practice, from March to November 2018, with a sample of 64 research subjects. Results: The results of this study indicate that there were significant values with p<0.05, namely the pulsatile value of the uterine artery index with a 1.228 cut-off point, Area Under Curve (AUC) of 78.2% (95% CI 59.3%-97%), sensitivity 80%, specificity 64.6%, PlGF level with 441 pg/ml cut-off point, Area Under Curve (AUC) of 82.5% (95% CI 61.5%-100%), sensitivity 80%, specificity 87.7%, sFlt-1 level with a cut-off point of 10087.5 pg/ml, Area Under Curve (AUC) of 81.2% (95% CI 63.6%-98.9%), sensitivity 80%, specificity 67.7% while sEng with p value>0.05 which means it is not significant. Conclusion: From this study, no significant differences were found in sEng, whereas differences were found in the pulsatile value of the uterine artery index, PlGF levels, and sFlt-1 levels in the incidence of early-onset preeclampsia. From the multivariate analysis, an examination of PlGF levels alone is sufficient as a predictor of early-onset preeclampsia.

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Arterial Resistance in Late First Trimester as a Predictor of Subsequent Pregnancy-Related Hypertension

Cited by 2 publications

References 25 publications

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

The Role of Predictor Placental Growth Factor, Soluble Endoglin, Soluble-FMS-Like-Tyrosine Kinase-1 and Pulsatil Uterina Arterial Index to Predict the Early Onset of Preeclampsia

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