Despite the growing enthusiasm for low-dose intra-arterial thrombolytic therapy, the efficacy and risks in specific clinical situations have not been defined. During the past 13 months, 10 infrainguinal bypass graft occlusions occurred in nine patients 2 to 48 months postoperatively and were treated with local infusions of either streptokinase or urokinase. The grafts treated included two saphenous vein femoropopliteal grafts, two expanded polytetrafluoroethylene (PTFE) femoropopliteal grafts, four saphenous vein femoroanterior tibial grafts, one saphenous vein-PTFE composite femoro-anterior tibial graft, and one saphenous vein-PTFE composite femoroperoneal graft. The graft occlusions occurred 2 to 14 days prior to initiation of treatment. The infusion failed to restore flow completely in seven grafts; and of the three successes, two patients required surgical treatment of complications. All successful recanalizations occurred within 48 hours of the initiation ofthrombolytic therapy. Of the seven failures, two patients had viable limbs and were discharged, whereas two required amputation (one above and one below knee). Three patients underwent surgical thrombectomy and revisions that were successfifl in two and resulted in a below-knee amputation in the other. Despite all precautions, complications occurred in five patients. Low-dose intra-arterial thrombolytic therapy is a poorly efficacious, risky method of infrainguinal graft occlusion management. (J VASC SURG 1985; 2:799-805.) The infrainguinal bypass graft is now widely accepted as an effective and durable method of revascularization of the ischemic lower extremity secondary to femoropopliteal occlusive disease. Nevertheless, progressive graft failure occurs over time? -6 "~vaft thrombosis in the immediate postoperative period invariably results from technical or judgmental error on the surgeon's part. There is little disagreement that prompt reoperation is indicated in this ,situation and will usually save the bypass graft. 7 When graft occlusion occurs later, weeks, months, or years after implantation, the causes may be more complex, treatment more difficult, and the results not always satisfactory. 4 Late thrombectomy of an autologous saphenous vein graft is particularly difficult From the Departments of Surgery (Drs. Perler, Ernst, and Williams) and Radiology, (Dr. White), The Johns Hopkins Medical Institutions.