Arterial Spin Labeling: Techniques, Clinical Applications, and                     Interpretation

Iutaka, Tatiana; Freitas, Marina Bellintani de; Omar, Samir Sari; Scortegagna, Felipe Alba; Nael, Kambiz; Nunes, Renato Hoffmann; Pacheco, Felipe Torres; Júnior, Antônio Carlos Martins Maia; Amaral, Lázaro Luís Faria do; Rocha, Antônio José da

doi:10.1148/rg.220088

Cited by 21 publications

(10 citation statements)

References 71 publications

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“…However, the results of the rBF value were satisfactory. In previous studies of cerebral blood flow perfusion, the relative cerebral perfusion value (Iutaka et al, 2023) was more concerning than the absolute value (Salisbury et al, 2022). However, a delayed arterial filling time is not diagnostic for ocular ischemia (Hung and Chang, 2017).…”

Section: Discussionmentioning

confidence: 94%

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Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Chen

Xue²,

Huang³

et al. 2023

Front. Neurosci.

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BackgroundOcular ischemic syndrome (OIS), attributable to chronic hypoperfusion caused by marked carotid stenosis, is one of the important factors that cause ocular neurodegenerative diseases such as optic atrophy. The current study aimed to detect blood flow perfusion in a visual pathway by arterial spin labeling (ASL) and magnetic resonance imaging (MRI) for the differential diagnosis of OIS.MethodsThis diagnostic, cross-sectional study at a single institution was performed to detect blood flow perfusion in a visual pathway based on 3D pseudocontinuous ASL (3D-pCASL) using 3.0T MRI. A total of 91 participants (91 eyes) consisting of 30 eyes with OIS and 61 eyes with noncarotid artery stenosis-related retinal vascular diseases (39 eyes with diabetic retinopathy and 22 eyes with high myopic retinopathy) were consecutively included. Blood flow perfusion values in visual pathways derived from regions of interest in ASL images, including the retinal-choroidal complex, the intraorbital segments of the optic nerve, the tractus optics, and the visual center, were obtained and compared with arm-retinal circulation time and retinal circulation time derived from fundus fluorescein angiography (FFA). Receiver operating characteristic (ROC) curve analyses and the intraclass correlation coefficient (ICC) were performed to evaluate the accuracy and consistency.ResultsPatients with OIS had the lowest blood flow perfusion values in the visual pathway (all p < 0.05). The relative intraorbital segments of optic nerve blood flow values at post-labeling delays (PLDs) of 1.5 s (area under the curve, AUC = 0.832) and the relative retinal–choroidal complex blood flow values at PLDs of 2.5 s (AUC = 0.805) were effective for the differential diagnosis of OIS. The ICC of the blood flow values derived from the retinal–choroidal complex and the intraorbital segments of the optic nerve between the two observers showed satisfactory concordance (all ICC > 0.932, p < 0.001). The adverse reaction rates of ASL and FFA were 2.20 and 3.30%, respectively.Conclusion3D-pCASL showed that the participants with OIS had lower blood flow perfusion values in the visual pathway, which presented satisfactory accuracy, reproducibility, and safety. It is a noninvasive and comprehensive differential diagnostic tool to assess blood flow perfusion in a visual pathway for the differential diagnosis of OIS.

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Section: Discussionmentioning

confidence: 94%

“…Select the delay time so that the image can be obtained, ideally when the water molecules and tissues are magnetized and exchanged. Arterial blood labeling is realized through the combination of pulse and gradient to reverse the longitudinal magnetization of blood-water protons (Iutaka et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Chen

Xue²,

Huang³

et al. 2023

Front. Neurosci.

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“…In recent years, technological advances in MRI scanner hardware and software and new cutting-edge analysis methods have positively impacted the range of ASL applications and resulted in notable growth in the number of publications [4][5][6] . Another factor for its increasing popularity in clinical research is the community effort to standardise acquisition methods, data structures, and analyses [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Feasibility of high-resolution perfusion imaging using Arterial Spin Labelling MRI at 3 Tesla

Kashyap

Oliveira

Uludağ

2023

Preprint

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Cerebral blood flow (CBF) is a critical physiological parameter of brain health, and it can be non-invasively measured with arterial spin labelling (ASL) MRI. In this study, we evaluated and optimized whole-brain, high-resolution ASL as an alternative to the low-resolution ASL employed in the routine assessment of CBF in both healthy participants and patients. Two high-resolution protocols (i.e., pCASL and FAIR-Q2TIPS (PASL) with 2 mm isotropic voxels) were compared to a default clinical pCASL protocol (3.4x3.4x4 mm3), all of whom had an acquisition time of ≈ 5 min. We assessed the impact of high-resolution acquisition on reducing partial voluming and improving sensitivity to the perfusion signal, and evaluated the effectiveness of z-deblurring on the ASL data. We compared the quality of whole-brain ASL acquired using three available head coils with differing numbers of receive channels (i.e., 20, 32, and 64 ch). In conclusion, this study demonstrates the feasibility of high-spatial resolution whole-brain ASL within the clinical scanning duration, offering higher spatial fidelity and resolving power than those obtained with current standard clinical ASL protocols.

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“…For this reason, this is an attractive imaging technique for children as well as patients with contraindications or previous untoward reactions to gadolinium, those with renal failure, and those who need repeated follow-up imaging. 2 Several ASL imaging techniques have been shown to get a reliable measurement of the renal perfusion for both healthy volunteers and those patients with one or more of the following pathologies: renal diseases, arterial stenosis, renal neoplasms, and allografts. 3 A recent meta-analysis reviews the role of ASL in assessing perfusion impairment in renal allografts, indicating that compared with healthy kidney transplant patients, renal ASL perfusion values were significantly lower in subjects with the functional imbalance of kidney transplants, with a positive correlation in the estimated glomerular filtration rate.…”

mentioning

confidence: 99%

“…ASL perfusion presents, as a major advantage, the fact that an exogenous tracer is unnecessary. For this reason, this is an attractive imaging technique for children as well as patients with contraindications or previous untoward reactions to gadolinium, those with renal failure, and those who need repeated follow‐up imaging 2 …”

mentioning

confidence: 99%

Editorial for “Significance of Arterial Spin Labeling for Reducing Biopsies in Patients With Kidney Allograft Dysfunction”

Robles

García‐López

García‐Martínez

2023

Magnetic Resonance Imaging

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Arterial Spin Labeling: Techniques, Clinical Applications, and Interpretation

Cited by 21 publications

References 71 publications

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Feasibility of high-resolution perfusion imaging using Arterial Spin Labelling MRI at 3 Tesla

Editorial for “Significance of Arterial Spin Labeling for Reducing Biopsies in Patients With Kidney Allograft Dysfunction”

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