Arterial Stiffness Alterations in Simulated Microgravity and Reactive Sledge as a Countermeasure

Krachtis, Agisilaos; Karkala, Aliki; Frantzidιs, Christos A.; Gkivogkli, Polyxeni T.; Ladas, Aristea; Strollo, Felice; Kourtidou‐Papadeli, Chrysoula

doi:10.1007/s40292-021-00486-2

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Another aspect of the long-term spaceflight is the microgravity effect on the arterial stiffness. Studies conducted on volunteers lying head down for a long time have shown that over time (up to 60 days) the value of arterial stiffness increases, which can be an adaptation to microgravity, but also a harmful factor for the cardiovascular system ( Krachtis et al, 2022 ). Research carried out during a 6-month space flight also indicated a 17%–30% increase, compared to values before the flight, in arterial stiffness measured within 38 h of returning to the Earth ( Hughson et al, 2016 ).…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Long-term space missions’ effects on the human organism: what we do know and what requires further research

Tomsia,

Cieśla,

Śmieszek

et al. 2024

Front. Physiol.

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Space has always fascinated people. Many years have passed since the first spaceflight, and in addition to the enormous technological progress, the level of understanding of human physiology in space is also increasing. The presented paper aims to summarize the recent research findings on the influence of the space environment (microgravity, pressure differences, cosmic radiation, etc.) on the human body systems during short-term and long-term space missions. The review also presents the biggest challenges and problems that must be solved in order to extend safely the time of human stay in space. In the era of increasing engineering capabilities, plans to colonize other planets, and the growing interest in commercial space flights, the most topical issues of modern medicine seems to be understanding the effects of long-term stay in space, and finding solutions to minimize the harmful effects of the space environment on the human body.

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Section: Cardiovascular Systemmentioning

confidence: 99%

Long-term space missions’ effects on the human organism: what we do know and what requires further research

Tomsia,

Cieśla,

Śmieszek

et al. 2024

Front. Physiol.

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“…Controlled studies aimed at investigating the effects of radiation, cosmic rays, or microgravity upon cells, tissues, and small living organisms—from bacteria to mice—have fostered the development of specific technological devices for more sophisticated 3D-cultures, which allow us to appreciate the critical role supplied by many different biophysical cues in biology. These conditions include shear stress [ 15 ], microfluidic-based approaches [ 16 ], cell colocation [ 17 ], organoid development [ 18 ], and environmental stiffness [ 19 ], just to mention a few. Overall, the investigation of cells/tissues growing in a modified physical milieu can serve as a novel paradigm for innovation, highlighting how architecture and physical interactions can efficiently shape the behavior of living structures.…”

Section: Progress In Basic and Applied Medical Knowledgementioning

confidence: 99%

Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology

et al. 2022

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Space biomedicine has provided significant technological breakthroughs by developing new medical devices, diagnostic tools, and health-supporting systems. Many of these products are currently in use onboard the International Space Station and have been successfully translated into clinical practice on Earth. However, biomedical research performed in space has disclosed exciting, new perspectives regarding the relationships between physics and medicine, thus fostering the rethinking of the theoretical basis of biology. In particular, these studies have stressed the critical role that biophysical forces play in shaping the function and pattern formation of living structures. The experimental models investigated under microgravity conditions allow us to appreciate the complexity of living organisms through a very different perspective. Indeed, biological entities should be conceived as a unique magnification of physical laws driven by local energy and order states overlaid by selection history and constraints, in which the source of the inheritance, variation, and process of selection has expanded from the classical Darwinian definition. The very specific nature of the field in which living organisms behave and evolve in a space environment can be exploited to decipher the underlying, basic processes and mechanisms that are not apparent on Earth. In turn, these findings can provide novel opportunities for testing pharmacological countermeasures that can be instrumental for managing a wide array of health problems and diseases on Earth.

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Exercise counteracts vascular aging in long-term spaceflight: challenges and perspective

Gao

Huang

Zhang

et al. 2023

Current Opinion in Physiology

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Arterial Stiffness Alterations in Simulated Microgravity and Reactive Sledge as a Countermeasure

Cited by 3 publications

References 25 publications

Long-term space missions’ effects on the human organism: what we do know and what requires further research

Long-term space missions’ effects on the human organism: what we do know and what requires further research

Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology

Exercise counteracts vascular aging in long-term spaceflight: challenges and perspective

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