Arterial stiffness and brain integrity: A review of MRI findings

Badji, Atef; Sabra, Dalia; Bherer, Louis; Cohen‐Adad, Julien; Girouard, Hélène; Gauthier, Claudine

doi:10.1016/j.arr.2019.05.001

Cited by 56 publications

(70 citation statements)

References 116 publications

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“…While more recent reports point to lower regional BF in the gray matter of individuals with increased arterial stiffness [67,68], earlier studies did not find such association [25,69,70]. This may be due to different study designs (cross-sectional versus longitudinal) and/or heterogeneity of target populations (young adult vs older adults) and/or differences in means to measure arterial stiffness as well as brain perfusion [13].…”

Section: Central Artery Stiffness and Bfmentioning

confidence: 86%

“…The key risk factors for dementia are old age, low education, APOE 4 allele, and cardiovascular risk factors [2,[6][7][8], among which the downstream effect of arterial stiffness on cerebral integrity has gained considerable research interest over the past few years [9][10][11]. Furthermore, arterial stiffness which is associated with hypertension and aging, has attracted a lot of attention for its impact on white matter [12,13]. However, the impact of arterial stiffness on white matter structure involved in the etiology of AD, including the corpus callosum remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…Arterial stiffness has also been shown to be associated with ischemic white matter hyperintensities (WMHs) manifesting on T2-weighted and fluidattenuated inversion recovery (FLAIR) images [12,13]. These white matter lesions are often associated with mild cognitive impairment and dementia [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…These white matter lesions are often associated with mild cognitive impairment and dementia [20][21][22][23]. Whether these WMHs are reversible or not is still unclear, however, they may be preceded by microstructural changes that can be detected with diffusion tensor imaging (DTI) [13,24].…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that the ISOVF, ICVF, and BF of the corpus callosum are best predicted by cfPWV as compared to other indexes of vascular aging (24h SBP, 24h PP, and AIx). Finally, as a recent literature review [13] supports the idea that white matter regions vulnerable to arterial stiffness contribute mainly to poorer performance in executive skills and cognitive flexibility, we wanted to investigate the relationship between our MRI metrics and the performance in executive function. We hypothesized that increased neuronal density and BF have a positive association with performance in cognitive flexibility.…”

Section: Introductionmentioning

confidence: 99%

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A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease

Badji

Colina

Boshkovski

et al. 2020

JAD

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Background: Vascular risk factors such as arterial stiffness play an important role in the etiology of Alzheimer’s disease (AD), presumably due to the emergence of white matter lesions. However, the impact of arterial stiffness to white matter structure involved in the etiology of AD, including the corpus callosum remains poorly understood. Objective: The aims of the study are to better understand the relationship between arterial stiffness, white matter microstructure, and perfusion of the corpus callosum in older adults. Methods: Arterial stiffness was estimated using the gold standard measure of carotid-femoral pulse wave velocity (cfPWV). Cognitive performance was evaluated with the Trail Making Test part B-A. Neurite orientation dispersion and density imaging was used to obtain microstructural information such as neurite density and extracellular water diffusion. The cerebral blood flow was estimated using arterial spin labelling. Results: cfPWV better predicts the microstructural integrity of the corpus callosum when compared with other index of vascular aging (the augmentation index, the systolic blood pressure, and the pulse pressure). In particular, significant associations were found between the cfPWV, an alteration of the extracellular water diffusion, and a neuronal density increase in the body of the corpus callosum which was also correlated with the performance in cognitive flexibility. Conclusion: Our results suggest that arterial stiffness is associated with an alteration of brain integrity which impacts cognitive function in older adults.

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Section: Central Artery Stiffness and Bfmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease

Badji

Colina

Boshkovski

et al. 2020

JAD

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Gray matter volume mediates the association of long‐term blood pressure variability with cognitive function in an adult population

Li,

Hui,

Shi

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWe delineated the associations among long‐term blood pressure variability (BPV), brain structure, and cognitive function.METHODSWe included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020.RESULTSHigher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume. Elevated DBPV was associated with lower volume of total brain and parietal GM, and higher white matter hyperintensity (WMH) volume. Higher SBPV and DBPV were associated with lower MoCA scores. Decreased total and regional GM volume and increased WMH volume were associated with lower MoCA scores. The association between SBPV and cognitive function was mediated by total, frontal, and temporal GM volume.DISCUSSIONGM volume may play key roles in the association between SBPV and cognitive function.Highlights SBPV and DBPV were negatively associated with total and regional brain volume. SBPV and DBPV were negatively associated with cognitive function. Decreased brain volume was associated with cognitive decline. GM volume mediated the negative association between SBPV and cognitive function.

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Hypertension and cerebral blood flow in the development of Alzheimer's disease

Bachmann,

Saake,

Studer

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWe investigated the interactive associations between amyloid and hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood flow (CBF) as a shared mechanism by which amyloid and hypertension contribute to EC tau and regional white matter hyperintensities (WMHs).METHODSWe analyzed data from older adults without dementia participating in the Add‐Tau study (NCT02958670, n = 138) or Alzheimer's Disease Neuroimaging Initiative (ADNI) (n = 523) who had available amyloid‐positron emission tomography (PET), tau‐PET, fluid‐attenuated inversion recovery (FLAIR), and T1‐weighted magnetic resonance imaging (MRI). A subsample in both cohorts had available arterial spin labeling (ASL) MRI (Add‐Tau: n = 78; ADNI: n = 89).RESULTSThe detrimental effects of hypertension on AD pathology and EC thickness were more pronounced in the Add‐Tau cohort. Increased amyloid burden was associated with decreased occipital gray matter CBF in the ADNI cohort. In both cohorts, lower regional gray matter CBF was associated with higher EC tau and posterior WMH burden.DISCUSSIONReduced cerebral perfusion may be one common mechanism through which hypertension and amyloid are related to increased EC tau and WMH volume.Highlights Hypertension is associated with increased entorhinal cortex (EC) tau, particularly in the presence of amyloid. Decreased cortical cerebral blood flow (CBF) is associated with higher regional white matter hyperintensity volume. Increasing amyloid burden is associated with decreasing CBF in the occipital lobe. MTL CBF and amyloid are synergistically associated with EC tau.

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Arterial stiffness and brain integrity: A review of MRI findings

Cited by 56 publications

References 116 publications

A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease

A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease

Gray matter volume mediates the association of long‐term blood pressure variability with cognitive function in an adult population

Hypertension and cerebral blood flow in the development of Alzheimer's disease

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