Arterial Stiffness and its Impact on Cardiovascular Health

Xuereb, Rachel Anne; Magri, Caroline J.; Xuereb, Robert G.

doi:10.1007/s11886-023-01951-1

Cited by 17 publications

(8 citation statements)

References 109 publications

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“…Based on the evidence that CDC42 plays a critical role in regulating atherosclerosis and vascular stiffness ( 20 , 22 ), some studies have investigated the abnormal level of CDC42 in patients with cerebrocardiovascular disease ( 23 , 24 ). For example, in one previous study, serum CDC42 is reduced in stroke patients compared to healthy individuals ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, there are several traditional cardiovascular factors associated with mortality in TBAD patients, such as age, hypertension, diabetes, and smoking ( 4 , 44 , 45 ). For example, the vascular function of hypertension patients is impaired, vascular stiffness is aggravated, and the latter is related to cardiovascular mortality ( 22 , 46 ). In addition, smoking is associated with elevated oxidative stress and proinflammatory factors in the aorta, which are associated with the progression of TBAD ( 47 – 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…Another study shows that the deletion of CDC42 promotes Th17 differentiation by facilitating glycolysis ( 19 ). Given that atherosclerosis, vascular stiffness, and abnormal differentiation of CD4 + T cells are involved in TBAD progression ( 20 – 22 ), CDC42 is suspected to serve as a biomarker for TBAD patients in clinical practice. However, the role of CDC42 in estimating TBAD risk and in-hospital mortality has not been fully explored, and limited relevant evidence is available thus far.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

Peng,

Wang,

Zhang

et al. 2024

Front. Cardiovasc. Med.

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ObjectiveCell division cycle 42 (CDC42) regulates CD4+T-cell differentiation and participates in vascular stiffness and atherosclerosis and is involved in the progression of Stanford type B aortic dissection (TBAD). This study aimed to explore the correlation between serum CDC42 level and CD4+T cell subsets and in-hospital mortality in TBAD patients.MethodsSerum CDC42 and peripheral blood T-helper (Th) 1, Th2, and Th17 cells were detected in 127 TBAD patients by enzyme-linked immunosorbent assay and flow cytometry, respectively. Serum CDC42 was also quantified in 30 healthy controls.ResultsSerum CDC42 was decreased in TBAD patients vs. healthy controls (median [interquartile range (IQR)]: 418.0 (228.0–761.0) pg/ml vs. 992.0 (716.3–1,445.8) pg/ml, P < 0.001). In TBAD patients, serum CDC42 was negatively correlated with Th17 cells (P = 0.001), but not Th1 (P = 0.130) or Th2 cells (P = 0.098). Seven (5.5%) patients experienced in-hospital mortality. Serum CDC42 was reduced in patients who experienced in-hospital mortality vs. those who did not (median (IQR): 191.0 (145.0–345.0) pg/ml vs. 451.5 (298.3–766.8) pg/ml, P = 0.006). By receiver operating characteristic analysis, serum CDC42 showed a good ability for estimating in-hospital mortality [area under curve = 0.809, 95% confidence interval (CI) = 0.662–0.956]. By the multivariate logistic regression analysis, elevated serum CDC42 [odd ratio (OR) = 0.994, 95% CI = 0.998–1.000, P = 0.043] was independently correlated with lower risk of in-hospital mortality, while higher age (OR = 1.157, 95% CI = 1.017–1.316, P = 0.027) was an independent factor for increased risk of in-hospital mortality.ConclusionSerum CDC42 negatively associates with Th17 cells and is independently correlated with decreased in-hospital mortality risk in TBAD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

Peng,

Wang,

Zhang

et al. 2024

Front. Cardiovasc. Med.

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“…Furthermore, a fructose-rich diet is associated with increased aortic stiffness in both rats [ 47 , 90 ] and humans [ 92 ]. Aortic stiffness is now recognized as a significant risk factor for cardiovascular disease and mortality [ 93 , 94 ]. Importantly, a recent meta-analysis of drinks sweetened with non-nutritive, FDA-approved additives, such as aspartame, stevia, sucralose, acesulfame potassium, monk fruit extract or advantame, show that such beverages do not provoke metabolic and endocrine effects that are seen with fructose [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Intake of Fructose Increases Arterial Pressure in Humans: A Meta-Analysis and Systematic Review

Siddiqui,

Rossi

2024

Nutrients

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Hypertension is a major cardiac risk factor. Higher blood pressures are becoming more prevalent due to changing dietary habits. Here, we evaluated the impact on blood pressure in human subjects after acutely ingesting fructose using meta-analysis. A total of 89 studies were collected from four different electronic databases from 1 January 2008 to 1 August 2023. Of these studies, 10 were selected that fulfilled all the criteria for this meta-analysis. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), and blood glucose level were analyzed using the Cohen’s d analysis or standardized mean difference at a confidence interval (CI) of 95%. The SBP, DBP, and MAP showed medium effect size; HR and glucose level displayed small effect size. The standardized mean difference of normal diet groups and fructose diet groups showed a significant increase in SBP (p = 0.04, REM = 2.30), and DBP (p = 0.03, REM = 1.48) with heterogeneity of 57% and 62%, respectively. Acute fructose ingestion contributes to an increase in arterial pressure in humans. The different parameters of arterial pressure in humans correlated with each other. These findings support further rigorous investigation, retrospective of necessity, into the effect of chronic dietary of fructose in humans in order to better understand the impact on long term arterial pressure.

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“…Studies have revealed a high prevalence of cardiovascular diseases and risk factors in COVID-19 patients [ 35 - 38 ]. Arterial stiffness is an important predictor of cardiovascular events and all-cause mortality [ 39 - 42 ]. Age, HTN, and other cardiovascular factors are associated with increased arterial stiffness, which, in combination with systemic inflammation, can worsen the course of COVID-19 [ 28 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI)

Podzolkov,

Bragina,

Tarzimanova

et al. 2024

CHYR

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Background:: COVID-19 is characterized by an acute inflammatory response with the formation of endothelial dysfunction and may affect arterial stiffness. Studies of cardio-ankle vascular index in COVID-19 patients with considered cardiovascular risk factors have not been conducted. Objective:: The purpose of our study was to assess the association between cardio-ankle vascular index and COVID-19 in hospitalized patients adjusted for known cardiovascular risk factors. Methods:: A cross-sectional study included 174 people hospitalized with a diagnosis of moderate COVID-19 and 94 people without COVID-19. Significant differences in the cardio-ankle vascular index values measured by VaSera VS - 1500N between the two groups were analyzed using parametric (Student's t-criterion) and nonparametric (Mann-Whitney) criteria. Independent association between COVID-19 and an increased cardio-ankle vascular index ≥ 9.0 adjusted for known cardiovascular risk factors was assessed by multivariate logistic regression. Results:: There were significantly higher values of the right cardio-ankle vascular index 8.10 [7.00;9.40] and the left cardio-ankle vascular index 8.10 [6.95;9.65] in patients undergoing inpatient treatment for COVID-19 than in the control group – 7.55 [6.60;8.60] and 7.60 [6.60;8.70], respectively. A multivariate logistic regression model adjusted for age, hypertension, plasma glucose level, glomerular filtration rate and diabetes mellitus showed a significant association between increased cardio-ankle vascular index and COVID-19 (OR 2.41 [CI 1.09;5.30]). Conclusion:: Hospitalized patients with COVID-19 had significantly higher cardio-ankle vascular index values compared to the control group. An association between an increased cardio-ankle vascular index and COVID-19 was revealed, independent of age, hypertension, plasma glucose level, glomerular filtration rate and diabetes mellitus.

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Arterial Stiffness and its Impact on Cardiovascular Health

Cited by 17 publications

References 109 publications

Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

Correlation of the serum cell division cycle 42 with CD4+ T cell subsets and in-hospital mortality in Stanford type B aortic dissection patients

Acute Intake of Fructose Increases Arterial Pressure in Humans: A Meta-Analysis and Systematic Review

Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI)

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