Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease

Pikilidou, Maria; Yavropoulou, Maria P; Αντωνίου, Μαρία; Papakonstantinou, E.; Pantelidou, Despoina; Chalkia, Panagiota; Nilsson, Peter M.; Yovos, John G.; Zebekakis, Pantelis

doi:10.1111/jch.12572

Cited by 24 publications

(16 citation statements)

References 28 publications

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“…This may be due to loss of sodium and water related to medullary tonicity defects (25). In addition to, high levels prostaglandin, decrease vascular reactivity and systemic vaso-dilatation response to micro-vascular dysfunction(6) or might be due to chronic activation of Nitric Oxide system (NO) (15,25).…”

Section: Discussionmentioning

confidence: 99%

Associations of Hyper-filtration and Proteinuria with Clinical Severity Score among Adult Sudanese Sickle anemia patients

Ma¹,

Nh²,

La³

2020

Preprint

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Background: Sickle Cell Anemia (SCA) is an autosomal recessive haemoglobinopathy with high morbidity and mortality. Global survival of sickle patients is increased and subsequently, prevalence of chronic complications including renal manifestations due to advances in management. Therefore, early detection and management of these complications become mandatory. This study aimed to investigate the estimated Glomerular Filtration Rate (eGFR), proteinuria and serum uric acid as markers of renal involvement in Sudanese sickle adults and association between these parameters and clinical severity score of sickle cell disease. Methods: Cross-sectional hospital-based study included thirty-two adult Sudanese patients diagnosed with SCA and twenty-three controls. Written informed consent was obtained. Blood and urine samples were collected. Severity score was calculated using Bios online calculator and eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula without adjustment for ethnicity. Results: Protein/Creatinine Ratio (PCR) was significantly higher (p-value < 0.001) in sickle cell anaemia group compared to controls. Hyper-filtration and Hyperuricemia were manifested in 75% and 6.3% of SCA group respectively. There was no association between the severity score and renal manifestations in the SCA group. Conclusions: Hyper-filtration and proteinuria were the most prevalent renal manifestations in SCA group. Further studies are recommended to determine the predictors of renal complications and early management of them.

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Section: Discussionmentioning

confidence: 99%

Associations of Hyper-filtration and Proteinuria with Clinical Severity Score among Adult Sudanese Sickle anemia patients

Ma¹,

Nh²,

La³

2020

Preprint

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“…They studied arterial stiffness and augmentation index (AIx) in patients with sickle cell disease (SCD). In their study, AIx was significantly higher in SCD patients compared with healthy controls; however, pulse wave velocity (PWV) was comparable between two groups, 1 suggesting the existence of different determinants of AIx and PWV. Patients with type 2 diabetes have increased arterial stiffness.…”

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confidence: 84%

Correlations of Arterial Stiffness and Augmentation Index With Metabolic Risk Factors in Patients With Type 2 Diabetes

Yanai

2015

J of Clinical Hypertension

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“…8,9 Evidence on the prevalence of hypertension and subclinical vascular damage as assessed by arterial stiffness in SCD populations is relatively few and with inconsistent results. [9][10][11][12] Some studies showed low blood pressure (BP) levels in SCD patients and similar levels of pulse wave velocity (PWV) with healthy controls, 10 while others showed increased stiffness and an inverse association of PWV with BP. 9,11 The interaction of BP and arterial stiffness on the in the study 16 pediatric SCD (HbS/β-thalassemia, S/β-thal) patients and 16 consecutive children at risk for hypertension referred to our hypertension clinic that served as high-risk controls.…”

Section: Introductionmentioning

confidence: 99%

Unmasking hypertension in children and adolescents with sickle/beta‐thalassemia

Stabouli¹,

Antza

Papadopoulou³

et al. 2020

J of Clinical Hypertension

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Sickle cell disease (SCD) is associated with increased risk of cardiovascular disease, although blood pressure (BP) levels have been reported to be lower in SCD patients compared to general population. Aims of the present study were to investigate the prevalence of BP phenotypes and levels of arterial stiffness in pediatric patients with SCD and to assess the differences with children at risk for hypertension. We included in the study 16 pediatric SCD (HbS/β‐thalassemia, S/β‐thal) patients and 16 consecutive children at risk for hypertension referred to our hypertension clinic that served as high‐risk controls. All patients underwent ambulatory BP monitoring and measurement of carotid‐femoral pulse wave velocity (PWV). S/β‐thal patients had lower office systolic BP than the high‐risk control group (115.43 ± 10.03 vs 123.37 ± 11.92, P = .05) but presented similar levels of day and night ambulatory BP. Office hypertension was found in 12.5% of the S/β‐thal patients and in 43.8% of the high‐risk controls (P = .06), while 18.8% of the S/β‐thal patients and 25% of the high‐risk controls presented hypertension by ambulatory BP levels (P = .21). All of the S/β‐thal patients with ambulatory hypertension had night hypertension (one combined night and day hypertension) with office normotension (masked hypertension). S/β‐thal patients and high‐risk controls presented equal prevalence of masked hypertension (18.8%). Children and adolescents with S/β‐thal present similar prevalence of BP phenotypes and levels of PWV with children at risk for hypertension. A significant number of children and adolescents with S/β‐thal may have masked nighttime hypertension despite normal office BP levels.

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Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease

Cited by 24 publications

References 28 publications

Associations of Hyper-filtration and Proteinuria with Clinical Severity Score among Adult Sudanese Sickle anemia patients

Associations of Hyper-filtration and Proteinuria with Clinical Severity Score among Adult Sudanese Sickle anemia patients

Correlations of Arterial Stiffness and Augmentation Index With Metabolic Risk Factors in Patients With Type 2 Diabetes

Unmasking hypertension in children and adolescents with sickle/beta‐thalassemia

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