Arterial Stiffness, Carotid Intima-Media Thickness, Endocan, and A Disintegrin and Metalloproteinase With Thrombospondin Type I Motif 9 Levels and Their Relationship With Disease Activity in Patients With Acromegaly With and Without Cardiovascular Risk Factors

Can, Mustafa; Kocabaş, Muhammet; Karaköse, Melia; Yerlikaya, Fatma Hümeyra; Alsancak, Yakup; Türkmen, Kültiğin; Kulaksızoğlu, Mustafa; Karakurt, Feridun

doi:10.1016/j.eprac.2021.11.084

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…While the echocardiographic aortic stiffness index (ASI) was similarly higher, the aortic strain and distensibility were decreased in patients with acromegaly being in remission and active acromegaly compared to controls without differences between these acromegaly groups [72]. Arterial stiffness was increased in patients with acromegaly with cardiovascular risk factors, and that increased arterial stiffness was associated with hemodynamic (systolic and diastolic BPs) and metabolic (body mass index, fasting plasma glucose level, and HbA1C level) parameters [81]. PWV was decreased in acromegaly patients compared to non-acromegalic control participants with similar cardiovascular risk profiles [82].…”

Section: In Acromegalymentioning

confidence: 99%

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Nemes,

Kormányos,

Ambrus

et al. 2023

JCM

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Acromegaly is an uncommon systematic endocrine disease caused by the hypersecretion of human growth hormone and, consequently, of insulin-like growth factor-1 during adulthood. Acromegaly could cause a typical cardiomyopathy characterized by left ventricular hypertrophy associated with diastolic dysfunction, which later could progress to systolic dysfunction. Moreover, some valvular and vascular abnormalities are also associated with acromegaly. This present review aims to summarize available information regarding acromegaly-associated abnormalities in myocardial, valvular, and vascular structural and functional properties and their relationship to disease activity and treatment options.

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Section: In Acromegalymentioning

confidence: 99%

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Nemes,

Kormányos,

Ambrus

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency

et al. 2024

CVP

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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over the last decades, evidence has demonstrated that pathologic conditions involving the GH-IGF-1 axis, as seen in GH excess to GH deficiency, are associated with an increased risk for CV morbidity and mortality. A significant part of that risk can be attributed to several accompanying comorbidities. In both conditions, disease control is associated with a consistent improvement of CV risk factors, reduction of CV mortality, and achievement of standardised mortality ratio similar to that of the general population. Data on the prevalence of peripheral arterial disease in patients with acromegaly or growth hormone deficiency and the effects of GH and IGF-1 levels on the disease progression is limited. In this review, we will consider the pivotal role of the GH-IGF-1 axis on CV system function, as well as the far-reaching consequences that arise when disorders within this axis occur, particularly in relation to the atherosclerosis process.

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Arterial Stiffness, Carotid Intima-Media Thickness, Endocan, and A Disintegrin and Metalloproteinase With Thrombospondin Type I Motif 9 Levels and Their Relationship With Disease Activity in Patients With Acromegaly With and Without Cardiovascular Risk Factors

Cited by 2 publications

References 34 publications

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency

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