Arterial stiffness in diabetes mellitus

Prenner, Stuart B.; Chirinos, Julio A.

doi:10.1016/j.atherosclerosis.2014.12.023

Cited by 260 publications

(265 citation statements)

References 99 publications

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“…The brachial-ankle PWV is increased not only in subjects with diabetes but also in those with glucose intolerance 25,26) . In a prospective study conducted previously, raised plasma glucose was found to accelerate age-related increase of the brachial-ankle PWV 27) .…”

Section: Glucose and Lipid Metabolismmentioning

confidence: 99%

“…Conventional risk factors for CV disease induce dysregulation of the balance between collagen and elastin, resulting in the overproduction of abnormal collagens and diminished production of normal elastin [43][44][45] . Aging and hypertension cause thinning, splitting, fraylevels of advanced glycation end-products are thought to be an important player in increasing the arterial stiffness, and a cross-link breaker has been shown to attenuate this increase of the arterial stiffness 26,28) . Abnormal lipid metabolism is thought to be related to increase of the arterial stiffness; however, inconsistent results have been reported on this association.…”

Section: Mechanisms Of Increased Arterial Stiffnessmentioning

confidence: 99%

“…Elevated blood pressure and vascular inflammation cause vascular smooth muscle cell hypertrophy [43][44][45] . Diabetes increases the accumulation of advanced glycation end products on collagen and elastin 26) , and chronic kidney disease increases arterial stiffness via arterial calcification 44,45) .…”

Section: Mechanisms Of the Initiation And Progression Of Cardiovasculmentioning

confidence: 99%

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Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Tomiyama

Matsumoto

Shiina

et al. 2016

J Atheroscler Thromb

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Since 2001, brachial-ankle pulse wave velocity (brachial-ankle PWV) measurement has been applied for risk stratification of patients with atherosclerotic cardiovascular disease and/or its risk factors in Japan. Measurement of the brachial-ankle PWV is simple and well standardized, and its reproducibility and accuracy are acceptable. Several cross-sectional studies have demonstrated a significant correlation between the brachial-ankle PWV and known risk factors for cardiovascular disease; the correlation is stronger in subjects with cardiovascular disease than in those without cardiovascular disease. We conducted a meta-analysis, which demonstrated that the brachial-ankle PWV is an independent predictor of future cardiovascular events. Furthermore, the treatment of cardiovascular risk factors and lifestyle modifications have been shown to improve the brachial-ankle PWV. Thus, at present, brachial-ankle PWV is close to being considered as a useful marker in the management of atherosclerotic cardiovascular disease and/or its risk factors.

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Section: Glucose and Lipid Metabolismmentioning

confidence: 99%

Section: Mechanisms Of Increased Arterial Stiffnessmentioning

confidence: 99%

Section: Mechanisms Of the Initiation And Progression Of Cardiovasculmentioning

confidence: 99%

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Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Tomiyama

Matsumoto

Shiina

et al. 2016

J Atheroscler Thromb

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“…One element relates to that longer-standing T2D is associated with silent vasculopathy, as illustrated by e.g., approximately 20% of clinically asymptomatic patients with T2D having significant coronary artery disease, either by invasive coronary angiography [3] or by photon emissioncomputed tomography myocardial perfusion imaging [4] . Further, since longer duration of the disease and advancing age typically lead to an accumulation of subclinical [such as vascular stiffness [5] , coronary artery calcifications (CAC) [6] , or myocardial dysfunction [7] ] or clinical manifestations of CV complications (i.e., myocardial infarction), or microvascular complications (which is an emerging risk factor for CV complications [8] ), it might be conceivable that if the patient population being studied has advanced vasculopathy, the likelihood to influence the disease course could be lower. In particular if end-stage complications have manifested, e.g., as observed in patients on dialysis where statins apparently do not reduce CV risk [9] , since these patients may be less sensitive to improvement in CV risk factors.…”

Section: The Relevance Of Contextualizing Outcome Trial Results To T2mentioning

confidence: 99%

Interpretation of cardiovascular outcome trials in type 2 diabetes needs a multiaxial approach

Johansen¹

2015

WJD

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“…Increased arterial stiffness is a result of aging (changes in extracellular matrix composition) (23) and is associated with hypertension, diabetes mellitus, atherosclerosis, and renal failure (35,40). We carefully excluded these factors from our study design by comparing our fPE group with a control group of the same age and by the exclusion of women with comorbidity.…”

Section: Discussionmentioning

confidence: 99%

Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study

Graaf

Paauw

Toering

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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van der Graaf AM, Paauw ND, Toering TJ, Feelisch M, Faas MM, Sutton TR, Minnion M, Lefrandt JD, Scherjon SA, Franx A, Navis G, Lely AT. Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study. Am J Physiol Heart Circ Physiol 310: H1827-H1833, 2016. First published April 8, 2016; doi:10.1152/ajpheart.00010.2016.-Women with a history of preeclampsia have an increased risk for cardiovascular diseases later in life. Persistent vascular alterations in the postpartum period might contribute to this increased risk. The current study assessed arterial stiffness under low sodium (LS) and high sodium (HS) conditions in a well-characterized group of formerly early-onset preeclamptic (fPE) women and formerly pregnant (fHP) women. Eighteen fHP and 18 fPE women were studied at an average of 5 yr after pregnancy on 1 wk of LS (50 mmol Na ϩ /day) and 1 wk of HS (200 mmol Na ϩ /day) intake. Arterial stiffness was measured by pulse-wave analysis (aortic augmentation index, AIx) and carotidfemoral pulse-wave velocity (PWV). Circulating markers of the reninangiotensin aldosterone system (RAAS), extracellular volume (ECV), nitric oxide (NO), and hydrogen sulfide (H2S) were measured in an effort to identify potential mechanistic elements underlying adaptation of arterial stiffness. AIx was significantly lower in fHP women on LS compared with HS while no difference in AIx was apparent in fPE women. PWV remained unchanged upon different sodium loads in either group. Comparable sodium-dependent changes in RAAS, ECV, and NO/H2S were observed in fHP and fPE women. fPE women have an impaired ability to adapt their arterial stiffness in response to changes in sodium intake, independently of blood pressure, RAAS, ECV, and NO/H2S status. The pathways involved in impaired adaptation of arterial stiffness, and its possible contribution to the increased long-term risk for cardiovascular diseases in fPE women, remain to be investigated.Listen to this article's corresponding podcast at http://ajpheart.podbean. com/e/vascular-health-after-preeclampsia/. preeclampsia; formerly preeclamptic women; cardiovascular risk; arterial stiffness; augmentation index; sodium intake NEWS & NOTEWORTHY This study assessed arterial stiffness in healthy formerly preeclamptic (fPE) women under standardized sodium intake and shows that fPE women have a blunted response to adapt their arterial stiffness in response to low sodium intake. This phenomenon might be a first indication of an unfavorable vascular profile in fPE women.PREECLAMPSIA complicates approximately 1-5% of all pregnancies (19) and is characterized by new-onset hypertension and proteinuria or other findings such as new-onset thrombocytopenia, renal insufficiency, neurological complications, liver involvement, and fetal growth restriction during the second half of pregnancy (1). Delivery of the placenta is the only therapeutic solution and results in rapid normalization of the maternal manifestations (46). Despite normalization of hypertension a...

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Arterial stiffness in diabetes mellitus

Cited by 260 publications

References 99 publications

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Interpretation of cardiovascular outcome trials in type 2 diabetes needs a multiaxial approach

Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study

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