Arterial stiffness in patients with coronary artery disease: relation with in-stent restenosis following percutaneous coronary intervention

Prskalo, Zrinko; Brizić, Ivica; Markota, Darko; Markota, Ivica; Boban, Mladen; Tomić, Monika; Starčević, Boris

doi:10.1186/s12872-016-0305-4

Cited by 18 publications

(21 citation statements)

References 31 publications

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“…With regard to CAD, aortic stiffness is associated with a broad range of patients, from apparently healthy subjects to those with cardiovascular risks and stable CAD, to postcoronary intervention [25][26][27][28]. One clinical study demonstrated that increased aortic stiffness using brachial-ankle PWV measured by volume-plethysmography was an independent predictor of 3-year cardiovascular event-free survival in patients with established CAD [28].…”

Section: Relationship Between Aortic Stiffness and Myocardial Ischemiamentioning

confidence: 99%

Incremental prognostic value of aortic stiffness in addition to myocardial ischemia by cardiac magnetic resonance imaging

Kaolawanich

Boonyasirinant

2020

BMC Cardiovasc Disord

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Background: Aortic stiffness is an independent predictor of cardiovascular (CV) events and mortality. However, no data exists for the prognosis of combined aortic stiffness and myocardial ischemia. Using cardiac magnetic resonance (CMR) imaging, we assessed the association of aortic stiffness by pulse wave velocity (PWV), myocardial ischemia, and CV events in patients with known or suspected coronary artery disease (CAD). Methods: Velocity-encoded CMR was performed in 520 patients who had undergone adenosine stress CMR. The PWV was determined between the mid-ascending and mid-descending thoracic aorta. Patients were divided into 4 groups by PWV (higher or lower PWV) and myocardial ischemia (positive or negative ischemia). Combined CV events including mortality, acute coronary syndrome, heart failure, coronary revascularization, and stroke were analyzed among the 4 groups. Results: The median follow-up period was 46.5 months, and the median PWV was 10.54 m/sec. Myocardial ischemia was positive in 199 patients (38.3%). The group with a higher PWV and positive ischemia had the most CV events (hazard ratio 8.94, p < 0.001). The group with a higher PWV and negative ischemia also was significantly associated with CV events (HR 2.19, p = 0.02). Groups with a lower PWV-positive ischemia and a higher PWV-negative ischemia showed no difference in terms of CV events (HR 0.60, p = 0.08). Patients with myocardial ischemia who had higher PWV demonstrated significantly higher event rates than those who had lower PWV (HR 2.41, p < 0.001). Multivariate analysis demonstrated that myocardial ischemia and PWV were independent predictors for combined CV events (HR 2.71, p < 0.001 and HR 2.42, p < 0.001, respectively). Conclusions: Stress perfusion CMR provided prognostic utility in patients with known or suspected CAD. Adding aortic stiffness to stress perfusion CMR could improve risk assessment and prediction for future CV events.

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Section: Relationship Between Aortic Stiffness and Myocardial Ischemiamentioning

confidence: 99%

Incremental prognostic value of aortic stiffness in addition to myocardial ischemia by cardiac magnetic resonance imaging

Kaolawanich

Boonyasirinant

2020

BMC Cardiovasc Disord

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“…HIV is capable of penetrating endothelial cells and is able to initiate inflammatory and biochemical intracellular reactions in the coronary arteries [10], the cerebral vasculature [11], and the aortic wall [12]. Moreover, aortic stiffness is associated with coronary artery disease [13,14]; and it is an independent predictor of coronary events [15]. However, there are contradictory findings on aortic stiffness measured by carotid-femoral pulse wave velocity (cfPWV) in treatment-naïve individuals living with HIV; with some studies showing similar [16,17] and others increased cfPWV, compared to controls [18,19].…”

Section: Introductionmentioning

confidence: 99%

Aortic stiffness and central hemodynamics in treatment-naïve HIV infection: a cross-sectional study

Martínez-Ayala

Alanis-Sánchez

Gonzalez-Hernández

et al. 2020

BMC Cardiovasc Disord

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Background Human immunodeficiency virus (HIV) infection is associated with a greater risk of cardiovascular disease (CVD). HIV infection causes a chronic inflammatory state and increases oxidative stress which can cause endothelial dysfunction and arterial stiffness. Aortic stiffness measured by carotid femoral-pulse wave velocity (cfPWV) and central hemodynamics are independent cardiovascular risk factors and have the prognostic ability for CVD. We assessed cfPWV and central hemodynamics in young individuals with recent HIV infection diagnosis and without antiretroviral therapy. We hypothesized that individuals living with HIV would present greater cfPWV and central hemodynamics (central systolic blood pressure and pulse pressure) compared to uninfected controls. Methods We recruited 51 treatment-naïve individuals living with HIV (HIV(+)) without previous CVD and 51 age- and sex-matched controls (HIV negative (−)). We evaluated traditional CVD risk factors including metabolic profile, blood pressure (BP), smoking, HIV viral load, and CD4+ T-cells count. Arterial stiffness and central hemodynamics were evaluated by cfPWV, central systolic BP, and central pulse pressure (cPP) via applanation tonometry. Results HIV(+) individuals presented a greater prevalence of smoking, reduced high-density lipoprotein cholesterol, and body mass index. 65.9% of HIV(+) individuals exhibited lymphocyte CD4+ T-cells count < 500 cells/μL. There was no difference in brachial or central BP between groups; however, HIV(+) individuals showed significantly lower cPP. We observed a greater cfPWV (mean difference = 0.5 m/s; p < 0.01) in HIV(+) compared to controls, even after adjusting for heart rate, mean arterial pressure and smoking. Conclusion In the early stages of infection, non-treated HIV individuals present a greater prevalence of traditional CVD risk factors, arterial stiffness, and normal or in some cases central hemodynamics.

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“…HIV is capable to penetrate and to initiate inflammatory and biochemical intracellular reactions in the endothelial cells of the coronary arteries [9], the cerebral vasculature [10], and the aortic wall [11]. Moreover, aortic stiffness is associated with coronary artery disease [12,13] and is an independent predictor of coronary events [14], but there are contradictory findings on aortic stiffness measured by carotid-femoral pulse wave velocity (cfPWV) in the setting of recent HIV diagnosis without ART.…”

Section: Introductionmentioning

confidence: 99%

Aortic stiffness and central hemodynamics in treatment naïve HIV infection: A cross-sectional study

Martínez-Ayala

Alanis-Sánchez

Gonzalez-Hernández

et al. 2020

Preprint

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Background: Human immunodeficiency virus (HIV) infection is associated with a greater risk of cardiovascular disease (CVD). HIV infection causes a chronic inflammatory state and increases oxidative stress which can cause endothelial dysfunction and arterial stiffness. Aortic stiffness measured by carotid femoral-pulse wave velocity (cfPWV) and central hemodynamics are independent cardiovascular risk factors and have the prognostic ability for CVD. We assessed cfPWV and central hemodynamics in young individuals with recent HIV infection diagnosis not receiving antiretroviral therapy. We hypothesized that HIV individuals would present greater cfPWV and central hemodynamics (central systolic blood pressure and pulse pressure) compared to uninfected controls. Methods. We recruited 51 treatment naïve HIV individuals (HIV(+)) without previous CVD and 51 age- and sex-matched controls (HIV(-)). We evaluated traditional CVD risk factors including metabolic profile, blood pressure (BP), smoking, and immune state. Arterial stiffness and central hemodynamics were evaluated by cfPWV, central systolic BP and central pulse pressure (cPP) via applanation tonometry. Results. HIV(+) individuals presented a greater prevalence of smoking, reduced high density lipoprotein cholesterol, and body mass index. 65.9% of HIV(+) individuals exhibited lymphocytes <500 cell/µL. There was no difference in brachial or central BP between groups; however, HIV(+) individuals showed significantly lower cPP. We observed a greater cfPWV (mean difference= 0.5 m/s; p<0.01) in HIV(+) compared to controls, even after adjusting for heart rate, mean arterial pressure and smoking. Conclusion: In the early stages of infection, non-treated HIV individuals present a greater prevalence of traditional CVD risk factors, arterial stiffness, and normal or decreased central hemodynamics.

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Arterial stiffness in patients with coronary artery disease: relation with in-stent restenosis following percutaneous coronary intervention

Cited by 18 publications

References 31 publications

Incremental prognostic value of aortic stiffness in addition to myocardial ischemia by cardiac magnetic resonance imaging

Incremental prognostic value of aortic stiffness in addition to myocardial ischemia by cardiac magnetic resonance imaging

Aortic stiffness and central hemodynamics in treatment-naïve HIV infection: a cross-sectional study

Aortic stiffness and central hemodynamics in treatment naïve HIV infection: A cross-sectional study

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