Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese &amp;mdash;A Population-Based Study (Taichung Community Health Study, TCHS)

Ho, Chih Te; Lin, Cheng Chieh; Hsu, Hua Shui; Liu, Chiu Shong; Davidson, Lance E.; Li, Tsai‐Chung; Li, Chia Ing; Lin, Wen Yuan

doi:10.5551/jat.5686

Cited by 39 publications

(27 citation statements)

References 26 publications

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“…To our knowledge, this is the first cohort study to show the impact of ADIPOQ G276T on prognoses and to suggest a mechanism of how ADIPOQ G276T affects the onset of stroke. Previous studies reported the correlation between PWV and silent cerebrovascular diseases 38) or insulin resistance 39) , and our results supported and provided new insight into these correlations.…”

Section: Discussionsupporting

confidence: 77%

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study

Kawai¹,

Ohishi²,

Takeya³

et al. 2013

JAT

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Aim: Adiponectin is a key molecule involved in metabolic syndrome. Single nucleotide polymorphisms (SNPs) in the ADIPOQ gene encoding adiponectin correlate with various diseases, such as diabetes mellitus; however, there is insufficient information about ADIPOQ SNPs and the onset of cardiovascular events. Methods: This hospital-based cohort study included 353 patients with essential hypertension (mean age, 62.9±0.6; mean follow-up period. 7.9±0.2 years) in whom ADIPOQ SNPs encoding G276T, I164T, A349G, and/or G967A amino acid changes were detected. We analyzed the correlation between ADIPOQ SNPs and various parameters, including pulse wave velocity (PWV), and assessed whether these SNPs could be risk factors for the onset of stroke, cardiovascular disease, and mortality. Results: Subjects with the T allele of G276T showed significantly lower HDL cholesterol, and significantly higher HbA1c and brachial-ankle PWV (baPWV). Kaplan-Meier analysis revealed that subjects with the T allele of G276T had a significantly higher frequency of stroke (p= 0.0489). The Cox proportional hazard model showed that the T allele of G276T was an independent and significant risk factor for stroke after adjusting for traditional risk factors (relative risk: 1.879, p = 0.0479); however, when adjusted for traditional risk factors and baPWV, the relative risk was significantly diminished (relative risk: 0.710, p=0.4937). G276T was significantly correlated with dyslipidemia and glucose metabolism. Conclusion: The T allele of G276T was a significant and independent risk for the onset of stroke, and mediated the incidence of stroke through increased arterial stiffness. J Atheroscler Thromb, 2013; 20:152-160.

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Section: Discussionsupporting

confidence: 77%

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study

Kawai¹,

Ohishi²,

Takeya³

et al. 2013

JAT

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“…On the other hand, some studies in non-diabetic and diabetic population show that IR increases significantly the risk for cardiovascular disease, independently of all classic and several nontraditional risk factors (Bonora et al, 2002(Bonora et al, , 2007Caravaca et al, 2010;Ho, Lin, Hsu, et al, 2011;Sciacqua et al, 2013;Shinohara et al, 2002;Tsuchiya, Nakayama, Iwashima, et al, 2007). Accumulating evidence suggests that patients with IR, even CKD patientsBanerjee, 2011, have impaired vascular function, leading to the development of atherosclerosis and consequently increased cardiovascular events Banerjee, 2011;Britton, Mukamal, Ix, et al, 2012;Ho et al, 2011;Sciacqua et al, 2013;Shinohara et al, 2002;Tsuchiya et al, 2007) since there are findings that support a variety of anti-atherogenic effect of insulin witch might be blunted by IR (Bonora et al, 2007). An et al (2012) showed that IR is an independent predictor for atherosclerosis plaque progression in patients with coronary heart disease in both diabetic and non-diabetic population.…”

Section: Discussionmentioning

confidence: 98%

Insulin resistance as a predictor of cardiovascular morbidity and end-stage renal disease

André

Mendes

Silva

et al. 2015

Journal of Diabetes and its Complications

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“…In contrast, insulin resistance and/or metabolic syndrome have been consistently associated with increased arterial stiffness in various ethnicities and in both genders. [32–35]…”

Section: Discussionmentioning

confidence: 99%

Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure

Hsu

Chuang

Cheng

et al. 2013

International Journal of Cardiology

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Background Uric acid may be involved in the pathogenesis of hypertension. We investigated the roles of four major hemodynamic parameters of blood pressure, including arterial stiffness, wave reflections, cardiac output (CO), and total peripheral resistance (TPR), in the association between uric acid and central systolic blood pressure (SBP-c). Methods A sample of 1303 normotensive and untreated hypertensive Taiwanese participants (595 women, aged 30–79 years) was drawn from a community-based survey. Study subjects’ baseline characteristics, biochemical parameters, carotid-femoral pulse wave velocity (cf-PWV), amplitude of the backward pressure wave decomposed from a calibrated tonometry-derived carotid pressure waveform (Pb), CO, TPR, and SBP-c were analyzed. Results In multi-variate analyses adjusted for age, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate, uric acid significantly correlated with Pb and cf-PWV in men, and Pb and TPR in women. The correlation between uric acid and Pb remained significant in men and women when cf-PWV was further adjusted. In the final multi-variate prediction model (model r2 = 0.839) for SBP-c, the significant independent variables included uric acid (partial r2 = 0.005), Pb (partial r2 = 0.651), cf-PWV (partial r2 = 0.005), CO (partial r2 = 0.062), TPR (partial r2 = 0.021), with adjustment for age, sex, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate. Conclusions Uric acid was significantly independently associated with wave reflections, which is the dominant determinant of SBP-c. Uric acid was also significantly associated with SBP-c independently of the major hemodynamic parameters.

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Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Abstract: Chih-Te Ho and Cheng-Chieh Lin contributed equally to this work.Aim: Few studies have investigated the association between insulin resistance and arterial stiffness in Chinese. We aimed to investigate this relationship in a population-based study of middle-aged Chinese.

Cited by 39 publications

References 26 publications

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study

Insulin resistance as a predictor of cardiovascular morbidity and end-stage renal disease

Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure

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