Arterial Stiffness Is the Independent Factor of Left Ventricular Hypertrophy Determined by Electrocardiogram

Chung, Chang-Min; Lin, Yu‐Sheng; Chang, Shih-Tai; Cheng, Hui-Wen; Yang, Teng-Yao; Hsiao, Ju-Feng; Pan, Kuo‐Li; Hsu, Jen-Te; Chu, Chi‐Ming

doi:10.1097/maj.0b013e318242a354

Cited by 34 publications

(31 citation statements)

References 23 publications

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“…Alterations in wave reflections combined with increased stiffness may also contribute to LVH [33], [38], [39]. Previous studies using different measurement methods of arterial stiffness have shown increased arterial stiffness was independently associated with LVH in a variety of populations [35], [36], [40]–[42]. Our study showed that a large bilateral baPWV difference was associated with LVMI.…”

Section: Discussionsupporting

confidence: 59%

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Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Lin

Hsu

et al. 2014

PLoS ONE

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Unequal arterial stiffness had been associated with cardiovascular risks. We investigated whether an association existed between unequal arterial stiffness indicated by bilateral brachial-ankle pulse wave velocity (baPWV) difference and ankle-brachial index (ABI), baPWV, echocardiographic parameters and interarm and interankle systolic blood pressure (BP) differences. A total of 1111 patients referred for echocardiographic examination were included in this study. The BPs, ABI and baPWV were measured simultaneously by an ABI-form device. The ΔbaPWV was defined as absolute value of difference between bilateral baPWV. We performed three multivariate analyses for determining the factors associated with a ΔbaPWV ≧ 185 cm/s (90 percentile of ΔbaPWV) (model 1: significant variables in univariate analysis and ABI <0.9 and baPWV; model 2: significant variables in univariate analysis and left ventricular mass index [LVMI]; model 3: significant variables in univariate analysis and interankle systolic BP difference ≧ 15 mmHg). The ABI <0.9 and high baPWV (both P<0.001) in model 1, high LVMI (P = 0.021) in model 2 and an interankle systolic BP difference ≧ 15 mmHg (P = 0.026) in model 3 were associated with a ΔbaPWV ≧ 185 cm/s, but the interarm systolic BP difference ≧ 10 mmHg was not (P = NS). Our study demonstrated ABI <0.9, high baPWV, high LVMI and an interankle systolic BP difference ≧ 15 mmHg were associated with unequal arterial stiffness.

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Section: Discussionsupporting

confidence: 59%

“…Some studies have reported a positive correlation between PWV and increased LVMI and LVH [35]–[37]. Arterial stiffness is associated with hypertrophy and atherosclerosis within the capacitance arteries that result in an increase in PWV and consequent alterations in the pressure waveform and increases in systolic and pulse pressure.…”

Section: Discussionmentioning

confidence: 99%

Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Lin

Hsu

et al. 2014

PLoS ONE

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“…Numerous studies have reported a positive correlation between increased LVMI and baPWV [26, 27]. Arterial stiffness may contribute to LVH independently of BP [26, 28]. Our current study showed that risk of LVH rose markedly in patients with baPWV>16m/s.…”

Section: Discussionsupporting

confidence: 65%

“…BaPWV is a promising technique to assess arterial stiffness in large population-based investigations [25]. Numerous studies have reported a positive correlation between increased LVMI and baPWV [26, 27]. Arterial stiffness may contribute to LVH independently of BP [26, 28].…”

Section: Discussionmentioning

confidence: 99%

Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Fan

et al. 2017

BMC Geriatr

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BackgroundLeft ventricular (LV) remodeling is closely linked to the progression of heart failure. There are limited data on the epidemiology of new onset LV remodeling among elderly women, which requires further investigation.MethodWe examined data from a community-based cohort of women aged > 65 years, who had received > 2 echocardiography scans from 2009 to 2014. Exclusion criteria for patients included prior echocardiographic evidence of left ventricular enlargement (LVE) or hypertrophy (LVH). LVE was defined as the index of left ventricular internal diameter at end-diastole to height, and LVH was defined as the left ventricular mass and thickness index which indicate hypertrophy.ResultsOf the 474 subjects (age 71.85 ± 6.47 years), 49 (10.3%) developed LVH, while 55 (11.6%) developed LVE during the mean follow-up period of 5 years. Independent predictors of LVH included: central blood pressure (CBP, per 10 mmHg) [HR 1.094, 95% CI 1.011–1.202], BMI˃25(kg/m 2)[HR 1.306, 95% CI 1.175–1.434], B-type natriuretic peptide (BNP) ≥ 100 (pg/mL) [HR 1.635, 95% CI 1.107–3.311] and brachial-ankle pulse wave velocity (baPWV) ≥16 m/s [HR 1.605, 95% CI 1.474–2.039]. Predictors of LVE were CBP (per 10 mmHg) [HR 1.121, 95% CI 1.027–1.238], BMI˃25(kg/m 2)[HR 1.302, 95% CI 1.173–1.444], Low-density lipoprotein cholesterol (LDL-C) [HR 1.193, 95%CI 1.013–1.405] and E/e’ ratio [HR 1.077, 95% CI 1.017–1.140].ConclusionCBP and BMI were demonstrated to be independent and robust predictors of left ventricular remodeling among elderly women, including both LVE and LVH. BNP and baPWV were specifically related to the development of LVH, whereas LDL-C and E/e’ ratio were related to LVE.

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“…When arterial walls lose elastic properties and become stiff, pulse waves that are generated from the heart, reflect back during the late systole period instead of diastolic period, resulting in an augmentation of systolic blood pressure (BP) and left ventricular load 1). Arterial stiffness is identified as an independent predictor of CVD including hypertension2) and left ventricular hypertrophy 1). Since pulse waves travel faster in stiffer arteries, determining pulse wave velocity (PWV) is generally accepted as a simple, noninvasive, and reproducible method of measuring arterial stiffness 3).…”

Section: Introductionmentioning

confidence: 99%

Resting Heart Rate and Aortic Stiffness in Normotensive Adults

Logan

Kim

2016

Korean Circ J

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Background and ObjectivesLarge-artery stiffness is an independent predictor of cardiovascular disease (CVD), and carotid-femoral pulse wave velocity (cfPWV) is considered the gold standard measure of arterial stiffness. A resting heart rate is an easily measured vital sign that is also associated with CVD morbidity and mortality. Previous studies have reported the significant relationship of a resting heart rate with arterial stiffness as measured by cfPWV only in hypertensive subjects; their relationship in nonhypertensive subjects remains unknown. The present study, therefore, examined their relationship in normotensive subjects.Subjects and MethodsIn 102 healthy Korean Americans between ages 20 and 60 years, their resting heart rate was measured by an automated blood pressure measuring device after a 10 minute rest in the supine position. Arterial stiffness was measured by cfPWV using the SphygmoCor device.ResultsThe mean resting heart rate of participants (mean age, 39.64 years; 59% women) was 61.91 bpm (standard deviation [SD], 9.62 bpm) and mean the cfPWV was 6.99 (SD, 1.14) m/s. A multiple regression analysis showed that a resting heart rate is a significant predictor of cfPWV after controlling for age, body mass index, and mean arterial pressure. For one bpm increase of resting heart rate, cfPWV increased approximately 0.02 m/s.ConclusionOur results suggest that a higher resting heart rate is independently associated with increased arterial stiffness as measured by cfPWV in normotensive adults. Arterial stiffness may explain the prognostic role of an individual's heart rate in cardiovascular morbidity and mortality.

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Arterial Stiffness Is the Independent Factor of Left Ventricular Hypertrophy Determined by Electrocardiogram

Cited by 34 publications

References 23 publications

Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study

Resting Heart Rate and Aortic Stiffness in Normotensive Adults

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