Arterial Stiffness Measured with the Cuff Oscillometric Method Is Predictive of Exercise Capacity in Patients with Cardiac Diseases

Tazawa, Yasushi; Mori, Nobuyoshi; Ogawa, Yoshiko; Itoh, Osamu; Kohzuki, Masahiro

doi:10.1620/tjem.239.127

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…A previous study reported that AVI could be an independent factor for peak VO2 in patients undergoing CR as it is elevated significantly in patients with coronary artery disease compared with patients with non-coronary artery disease while correlating inversely with the peak VO2. 33) In the present study, we used the left ventricular EF to stratify subjects and found that AVI was an independent factor of peak VO2 in the group of patients with pEF. In addition, there was a significant negative correlation between AVI and peak VO2 in the pEF group with CHF at admission.…”

Section: Discussionmentioning

confidence: 68%

Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation

et al. 2021

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Arterial stiffness contributes to the development of cardiovascular disease (CVD). However, the relationship between the arterial stiffness and exercise tolerance in CVD patients with preserved ejection fraction (pEF) and those with reduced EF (rEF) is unclear. We enrolled 358 patients who participated in cardiac rehabilitation and underwent cardiopulmonary exercise testing at Juntendo University Hospital. After excluding 195 patients who had undergone open heart surgery and 20 patients with mid-range EF, the patients were divided into pEF (n = 99) and rEF (n = 44) groups. Arterial stiffness was assessed using arterial velocity pulse index (AVI) and arterial pressure volume index (API) at rest. The patients in the pEF group were significantly older and had a higher prevalence of coronary artery disease than the rEF group. The pEF group had significantly lower AVI levels and higher API levels than the pEF group. In the pEF group, the peak oxygen uptake (peak VO2) and the anaerobic threshold was significantly higher than those in the rEF group. The peak VO2 was significantly and negatively correlated with AVI and API in the pEF group (All, P < 0.05), but not in the rEF group. Multivariate linear regression analyses demonstrated that AVI was independently associated with peak VO2 (β = −0.34, P < 0.05) in the pEF group. In conclusion, AVI may be a useful factor for assessing exercise tolerance, particularly in CVD patients with pEF.

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Section: Discussionmentioning

confidence: 68%

Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation

et al. 2021

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“…Previous studies have demonstrated that the AVI is associated with the number of cardiovascular risk factors, the Framingham risk score (Sasaki-Nakashima et al 2017) and CAD (Tazawa et al 2016). The predictive value of AVI in ischemic cardiac disease has also been confirmed in patients with type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 83%

“…Another study from Saitama Medical University (Akiyama et al 2010) showed that both AVI and API were significantly related to the development of ischemic cardiac disease in patients with type 2 diabetes. Tazawa et al (2016)found that increased AVI was associated with CAD and reduced exercise capacity in patients with cardiac diseases. A more recent study comprising of 252 participants (149 men and 103 women) revealed that API was independently associated with the Framingham risk score (Sasaki-Nakashima et al 2017) .…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Assessment of Early Atherosclerosis Based on New Arterial Stiffness Indices Measured with an Upper-Arm Oscillometric Device

Zhang

Yin

et al. 2017

Tohoku J. Exp. Med.

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The clinical significance of detecting early atherosclerosis is now widely recognized. Measurement methods available at present are usually not suitable for use in primary care where rapid screening for a large population is needed. The Arterial Velocity-pulse Index (AVI) and Arterial Pressure-volume Index (API) are new noninvasive arterial stiffness indices that can be rapidly measured using an oscillometric device. The purpose of this study was to determine whether high AVI and API values are predictive of early atherosclerosis prior to the onset of obstructive coronary artery disease (CAD). A total of 183 patients were enrolled and allocated to the CAD group (n = 109), early atherosclerosis (AS) group (n = 34) or an apparently healthy (non-AS) group (n = 40) based on the results of angiographic examinations. Measurements for arterial blood pressure, AVI, API and brachial-ankle pulse wave velocity (baPWV) were collected. Statistical analyses revealed that AVIs were significantly lower in the non-AS group than in the AS group and the CAD group. The inter-group differences in API were not statistically significant among the 3 patient groups. As a reference, baPWV was found to be statistically higher in the CAD group than in the non-AS group, whereas there was no significant difference between the CAD group and the AS group, or between the AS group and the non-AS group. The AVI and API were both significantly correlated with baPWV. This study demonstrated that AVI was more sensitive than baPWV and API in indicating early atherosclerosis, although elevated AVI and baPWV were both predictive of CAD.

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“…The AVE-1500 (Shisei Datum, Tokyo, Japan) is a newly developed device that can non-invasively evaluate arterial stiffness and endothelial dysfunction of the central arteries (arterial velocity pulse index [AVI]) and peripheral arteries (arterial pressure volume index [API]) using a cuff-oscillometric technique in a single blood pressure measurement. We previously reported that the AVI and API are significantly correlated but showed different CV implications 6,7) ; conversely, other studies have reported various implications of these indexes for CV risks [8][9][10][11] . Additionally, both the severity of coronary heart disease and complexity of the coronary artery in affected patients are significantly correlated with API 7) .…”

Section: Introductionmentioning

confidence: 79%

Successful prediction of clinical outcomes using arterial velocity pulse index, a new non-invasive vascular index, in Japan

et al. 2020

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Objectives: Earlier detection of vascular stiffness and endothelial dysfunction will be useful in preventing atherosclerotic catastrophic conditions. Individuals with high risks for future cardiovascular (CV) events should be recognized by physicians to strengthen preventive therapeutic procedures, such as antihypertensive therapy, antidiabetic therapy, and antidyslipidemic therapy. As such, various non-invasive devices have been developed and are currently applied in clinical settings. Among them, we previously reported arterial velocity pulse index (AVI) and arterial pressure volume index (API) measured using a cuff-oscillometric-based medical electronic blood pressure monitor. These are significantly correlated with arterial stiffness and cardiac overload; therefore, these indexes might be useful in predicting future CV events. Materials and methods: We performed survival and CV event analyses in a total of 180 subjects with various clinical implications who visited Yokohama City University Hospital between May 2013 and March 2015 and followed them up until March 2016. The mean age was 66±13 years, and 101 subjects (56.1%) were men. A total of 116 subjects (64.4%) had hypertension, 87 subjects (48.3%) had dyslipidemia, and 39 subjects (21.7%) had diabetes mellitus. The mean AVI and API were 23.3±7.7 and 31.8±8.4, respectively. Results: The mean follow-up duration was 769±275 days. A total of 13 major adverse cardiac events (MACEs) occurred during the observational period, which consisted of 1 cardiac death, 8 CV events, and 4 hospitalizations owing to heart failure. After we performed Kaplan-Meier analysis, univariate Cox proportional hazard regression analysis, and multivariate Cox proportional hazard regression analysis, we found that AVI is significantly correlated with the risk of MACE. Therefore, we successfully revealed the clinical implications of the new non-invasive indexes for CV mortality and morbidity. Conclusion: The new non-invasive vascular index, AVI, was significantly correlated with the CV outcomes in our Japanese cohort.

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Arterial Stiffness Measured with the Cuff Oscillometric Method Is Predictive of Exercise Capacity in Patients with Cardiac Diseases

Cited by 11 publications

References 53 publications

Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation

Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation

Non-Invasive Assessment of Early Atherosclerosis Based on New Arterial Stiffness Indices Measured with an Upper-Arm Oscillometric Device

Successful prediction of clinical outcomes using arterial velocity pulse index, a new non-invasive vascular index, in Japan

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