Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event

Levisianou, D.; Foussas, Stefanos; Skopelitis, Elias; Adamopoulou, Evdokia N.; Xenopoulou, Theodora; Destounis, Antonios; Koukoulis, Georgios; Skoularigis, Ioannis; Melidonis, Andreas; Triposkiadis, Filippos

doi:10.1016/j.diabres.2012.11.023

Cited by 16 publications

(10 citation statements)

References 30 publications

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“…Taken together, these data highlight the accelerated arterial aging in type 1 diabetes and may explain, at least in part, the increased CV risk in these patients. A large body of evidence supports the concept of increased arterial stiffness in type 2 diabetes [91,92]. Similar to that observed in type 1 diabetes, this again is an early phenomenon because much already occurs in the impaired glucose metabolism state (i.e., impaired fasting glucose and/or impaired glucose tolerance).…”

Section: Discussionmentioning

confidence: 52%

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications

Giallauria

Vigorito

Ferrara

et al. 2013

Curr Transl Geriatr and Exp Gerontol Rep

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Vascular calcification, a hallmark of aging, is accelerated in patients with hypertension, diabetes, and chronic kidney disease. It may be viewed as the result of disturbances of the complex and subtle balance between inhibitors and promoters, acting at both the systemic and local levels. Ethnic differences in certain components of the atherosclerosis process were identified previously; however, recent evidence suggests that atherosclerosis is not a modern disease and may be viewed as an inherent component of human aging, unrelated to any specific diet or lifestyle. In this review, we highlight the mechanisms governing vascular calcification and its association with aging. By understanding the pathways involved in these processes, novel drug targets may be proposed in an effort to reduce the effects of vascular calcification as a risk factor.

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Section: Discussionmentioning

confidence: 52%

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications

Giallauria

Vigorito

Ferrara

et al. 2013

Curr Transl Geriatr and Exp Gerontol Rep

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“…The TyG index per se was reported to be positively associated with arterial stiffness as assessed by brachialankle or carotid-femoral pulse wave velocity, which have been demonstrated to predict the long-term risk of adverse CV events in patients with T2DM and ACS [37][38][39]. Of note, the TyG index includes triglycerides and glucose in its formula.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride glucose index for predicting cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes mellitus and acute coronary syndrome

Dong

Shao

et al. 2020

Cardiovasc Diabetol

157

147

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Background: The triglyceride glucose (TyG) index, a simple surrogate estimate of insulin resistance, has been demonstrated to predict cardiovascular (CV) disease morbidity and mortality in the general population and many patient cohorts. However, to our knowledge, the prognostic usefulness of the TyG index after percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS) has not been determined. This study aimed to evaluate the association of the TyG index with adverse CV outcomes in patients with T2DM and ACS who underwent PCI. Methods: The TyG index was calculated using the formula ln[fasting triglycerides (mg/dL) × fasting glucose (mg/ dL)/2]. The primary endpoint was the composite of all-cause mortality, non-fatal stroke, non-fatal myocardial infarction, or unplanned repeat revascularization. The association between the TyG index and adverse CV outcomes was assessed by Cox proportional hazards regression analysis. Results: In total, 776 patients with T2DM and ACS who underwent PCI (mean age, 61 ± 10 years; men, 72.2%) were included in the final analysis. Over a median follow-up of 30 months, 188 patients (24.2%) had at least 1 primary endpoint event. The follow-up incidence of the primary endpoint rose with increasing TyG index tertiles. The multivariate Cox proportional hazards regression analysis adjusted for multiple confounders revealed a hazard ratio for the primary endpoint of 2.17 (95% CI 1.45-3.24; P for trend = 0.001) when the highest and lowest TyG index tertiles were compared. Conclusions: The TyG index was significantly and positively associated with adverse CV outcomes, suggesting that the TyG index may be a valuable predictor of adverse CV outcomes after PCI in patients with T2DM and ACS.

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“…Another article reported [19] that the survival rate significantly decreased when PWV >12 m/s. A fixed threshold value (12 m/s) was proposed as AS in the 2007 ESH/ESC hypertension guidelines based on published epidemiological studies [20] .…”

Section: Discussionmentioning

confidence: 99%

Pulse Wave Velocity: A Valuable Predictor for Cardio-Cerebrovascular Disease and Death in PD Patients

Xu¹,

Xie²,

Zong³

et al. 2015

Blood Purif

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Aims: To evaluate the value of pulse wave velocity (PWV) to predict cardio-cerebrovascular (CVD) and death in peritoneal dialysis (PD) patients. Methods: In all, 59 maintenance PD patients from January 2012 to December 2012 were enrolled. Patients were classified as group A (>9 m/s) and group B (≤9 m/s), based on the results of carotid-femoral PWV (CF-PWV). Results: CF-PWV was positively correlated with age (r = 0.71, p < 0.01), left atrial diameter (r = 0.58, p < 0.01), left ventricular mass index (r = 0.59, p < 0.01) and 24H average systolic blood pressure (SBP) (r = 0.57, p < 0.01). Age (relative risk (RR) 1.086, 95% confidence interval (CI) 1.024-1.153, p < 0.01) and 24H average SBP (RR 1.047, 95% CI 1.013-1.082, p < 0.01) were risk factors of higher CF-PWV. The cumulative and new CVD free survival rates of group A significantly decreased. Elder (RR 1.114, 95% CI 1.013-1.224, p = 0.026) and higher PWV (RR 1.482, 95% CI 1.01-2.176, p = 0.044) were risk factors of CVD in PD patients. Conclusion: PWV is a valuable predictor of CVD and death in PD patients.

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Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event

Cited by 16 publications

References 30 publications

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications

Triglyceride glucose index for predicting cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes mellitus and acute coronary syndrome

Pulse Wave Velocity: A Valuable Predictor for Cardio-Cerebrovascular Disease and Death in PD Patients

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