Arterial stiffness predicts severe progression in systemic sclerosis: the ERAMS study

Constans, J.; Germain, C.; Gosse, Philippe; Taillard, Jacques; Tiev, Kiet; Delévaux, I.; Mouthon, Luc; Schmidt, Claude H.; Granel, F; Soria, P.; Lifermann, François; Etienne, G; Bonnet, Fabrice; Zoulim, Karim; Farge‐Bancel, Dominique; Marié, Isabelle; Allanore, Yannick; Cabané, J.; Amonchot, Alain; Macquin‐Mavier, I.; Savès, Marianne; Zannad, Faı̈ez; Conri, C.

doi:10.1097/hjh.0b013e328244e1eb

Cited by 32 publications

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“…The index obtained, measured QKD 100-60 /heightpredicted theoretical value, QKDh, is inversely related to AS. It is significantly reduced in the hypertensive and in other populations where AS is increased (renal failure 15 and systemic sclerosis 16 ). A criticism of this technique is the evaluation of the transmission of the pulse wave over a territory, including muscular arteries (subclavian and brachial).…”

Section: Discussionmentioning

confidence: 97%

“…This index also has a prognostic value for worsening of systemic sclerosis. 16 This new analysis of our cohort is based on a larger number of CVE (122 versus 62 23 ). It confirms our previous results showing a relation between QKDh and CVE independently of age, mean 24-hour BP (SBP, PP, or MBP), sex, diabetes mellitus, smoking, and hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 99%

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Arterial Stiffness From Monitoring of Timing of Korotkoff Sounds Predicts the Occurrence of Cardiovascular Events Independently of Left Ventricular Mass in Hypertensive Patients

et al. 2013

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Markers of subclinical target organ damage increase cardiovascular risk prediction beyond traditional risk factors. Arterial stiffness (AS) is one of these markers. 1 The predictive value for future cardiovascular events (CVEs) has been demonstrated for the carotido-femoral pulse wave velocity (PWV) in patients with renal failure, 2 in hypertensives, 3 and in the general population, 4 as well as from ambulatory measurement of the timing of Korotkoff sounds (QKD) in hypertensives. 5 The predictive value of AS is independent of traditional risk factors: sex, age, diabetes mellitus, smoking, cholesterol, and blood pressure (BP), even when monitored during 24 hours with the QKD method. However, very few studies 6 have compared the respective predictive values of different markers of target organ damage. This is a major issue because the question whether all parameters should be measured, or only some of them, in routine condition is opened. To date there are no studies that have evaluated the prognostic value of AS in comparison with another powerful risk factor, left ventricular mass (LVM) as measured by echocardiography in hypertensive patients We evaluated the prognostic value of these 2 parameters in the same population of patients with essential hypertension using the QKD method, which offers the advantages to combine 24-hour BP monitoring and an estimation of AS independent of BP. Methods PopulationThe patients included in this study belong to the Bordeaux cohort of hypertensive. This registry was started in 1984 and includes all patients consecutively referred to our center before administration of antihypertensive treatment and fulfilling the following criteria:Office BP>140/90 on ≥2 occasions; Essential hypertension. Absence of cardiovascular complications or pathology likely to affect the prognosis, absence of type 1 diabetes mellitus.For the validity of the ambulatory measurement of AS, 2 other selection criteria were used.Absence of bundle-branch block on ECG (QRS duration <120 ms). Absence of known thyroid pathology.All the patients gave their consent to participation in this registry, which was approved by our local committee of ethics and protection See Editorial Commentary, pp 10-12Abstract-Several studies have established that the increase in arterial stiffness (AS) is a cardiovascular risk factor but to date no studies have evaluated in hypertensive patients its prognostic value in comparison with another powerful risk factor, left ventricular mass (LVM) as measured by echocardiography. We prospectively evaluated the prognostic value of AS and LVM in patients with essential hypertension. The population studied comprised 793 patients (56% men) aged 54±14 years. For 519 patients, baseline measurements were made before any antihypertensive treatment, for 274 patients, the measurement were obtained during the follow-up period under antihypertensive treatment. AS was assessed from ambulatory monitoring of blood pressure and timing of Korottkoff sounds. Left ventricular mass was measured in 523 patients....

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Arterial Stiffness From Monitoring of Timing of Korotkoff Sounds Predicts the Occurrence of Cardiovascular Events Independently of Left Ventricular Mass in Hypertensive Patients

et al. 2013

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“…Il a été aussi postulé que la RA serait un FRCV indépendant et mieux corrélé à la morbidité cardio-vasculaire [11]. Elle aurait une valeur prédictive sur la progression de la SS et surtout sur la survenue de la crise rénale, de l'hypertrophie ventriculaire, ainsi que des calcifications [11,12].…”

Section: Discussionunclassified

Evaluation of arterial stiffness by finger-toe pulse wave velocity measured by pOpmetre® in black africans patients with systemic scleroderma

Diallo¹,

Touré²,

Diatta³

et al. 2017

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Background: The purpose of this study was to assess the arterial stiffness (AS) in black africans patients with systemic scleroderma. Patients and Methodology: A prospective cross-sectional hospital survey has been performed over a 6-month period, including 55 black african individuals, aged over 16 years and consenting, consisting of 29 patients with systemic scleroderma and 26 hospitalized controls. The finger-toe pulse wave velocity (ft-PWV) was recorded by popmetre® and comparaison between the 2 groups has been performed with statistical analysis. Results: The mean ft-PWV was 9,56 m/s ± 3,09 in the patient group and 7,71 m/s ± 2,63 in control group. The ft-PWV was significantly higher in patients with scleroderma compared to controls (p<0.0145). The study of the relationship between AS and independent variables in multivariate analysis demonstrated that having scleroderma increase by 1.81 times the value of the ft-PWV after adjustment for age and systolic blood pressure. Discussion: To our knowledge, this is the first assessment of the AS in black african patients with scleroderma. It shows that ft-PWV was significantly higher in patients with scleroderma compared to controls. Also, this high AS was imputable to the scleroderma. Conclusion: In Africa, the measurement of the AS by popmetre® could be a simple, rapid, non invasive and pratical early detection and follow-up of cardio-vascular involvments in the course of scleroderma.

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“…Сдвиги Степень выраженности изменений упругоэластиче-ских свойств сосудов, вероятно, может быть предиктором активности патологического процесса при ССД. Это пред-положение подтверждается и данными недавно опублико-ванного многоцентрового проспективного исследования ERAMS, демонстрирующими достоверную ассоциацию между жесткостью сосудистой стенки и выраженностью легочной гипертензии, являющейся одним из основных проявлений сосудистых нарушений при ССД [14].…”

Section: Discussionunclassified

Microcirculatory disorders in scleroderma systematica: an association with vascular wall stiffness

Ruzhentsova¹

2013

rsp

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Arterial stiffness predicts severe progression in systemic sclerosis: the ERAMS study

Abstract: The measurement of arterial stiffness by the QKd method is a useful objective method for assessing the prognosis of systemic sclerosis independently from other data.

Cited by 32 publications

References 20 publications

Arterial Stiffness From Monitoring of Timing of Korotkoff Sounds Predicts the Occurrence of Cardiovascular Events Independently of Left Ventricular Mass in Hypertensive Patients

Arterial Stiffness From Monitoring of Timing of Korotkoff Sounds Predicts the Occurrence of Cardiovascular Events Independently of Left Ventricular Mass in Hypertensive Patients

Evaluation of arterial stiffness by finger-toe pulse wave velocity measured by pOpmetre® in black africans patients with systemic scleroderma

Microcirculatory disorders in scleroderma systematica: an association with vascular wall stiffness

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