Arterial Tissue of Arsenic, Selenium and Iron in Blackfoot Disease Patients

Wang, Chin Thin; Chang, Wei Tun

doi:10.1515/cclm.2001.105

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Combining the studies in Table 1 [24, 27, 28••, 29•, 30, 33–40] with the studies from Taiwan summarized in the previous systematic review and in Online Resource 3 [23, 25, 52–58], the pooled relative risk estimates comparing the highest to lowest arsenic exposure categories were 1.32 for CVD (95 % CI: 1.05–1.67; p -heterogeneity = 0.098; I 2 = 43.9 %), 1.89 for CHD (95 % CI: 1.33–2.69; p -heterogeneity = 0.004; I 2 = 70.7 %), 1.08 for stroke (95 % CI: 0.98–1.19; p -heterogeneity = 0.001; I 2 = 74.4 %) and 2.17 for PAD (95 % CI: 1.47–3.20; p -heterogeneity < 0.001; I 2 = 87.7 %) (Table 2, Figure 1, Online Resource 5). One study was particularly influential for stroke [37]; after omitting it, the pooled relative risk for stroke was 1.12 (95 % CI: 1.04–1.22).…”

Section: Resultsmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Moon

Güallar

Navas‐Acien

2012

Curr Atheroscler Rep

313

145

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In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037–49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05–1.67), 1.89 (95 % CI: 1.33–2.69), 1.08 (95 % CI: 0.98–1.19), and 2.17 (95 % CI: 1.47–3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

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Section: Resultsmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Moon

Güallar

Navas‐Acien

2012

Curr Atheroscler Rep

313

145

View full text Add to dashboard Cite

show abstract

“…Arsenic was associated with CVD, CHD and PAD in all studies conducted in high arsenic exposure areas, and it was associated with stroke in six of the seven studies (Table 1). Combining the studies in Table 1 [52][53][54][55][56][57][58], the pooled relative risk estimates comparing the highest to lowest arsenic exposure categories were 1.32 for CVD (95 % CI: 1.05-1.67; p-heterogeneity = 0.098; I 2 = 43.9 %), 1.89 for CHD (95 % CI: 1.33-2.69; p-heterogeneity = 0.004; I 2 = 70.7 %), 1.08 for stroke (95 % CI: 0.98-1.19; p-heterogeneity = 0.001; I 2 = 74.4 %) and 2.17 for PAD (95 % CI: 1.47-3.20; p-heterogeneity < 0.001; I 2 = 87.7 %) (Table 2, Figure 1, Online Resource 5).…”

Section: Studies In High Arsenic Exposure Areasmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease: An Updated Systematic Review

Moon¹,

Güallar²,

Navas‐Acien³

2013

ISEE Conference Abstracts

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In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037-49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05-1.67), 1.89 (95 % CI: 1.33-2.69), 1.08 (95 % CI: 0.98-1.19), and 2.17 (95 % CI: 1.47-3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between highchronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

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“…Arsenic is likely to cause blackfoot disease, a severe form of peripheral arterial disease in southwestern Taiwan that is characterized by thromboangiitis obliterans, severe arteriosclerosis, and high arsenic levels in the arterial wall (3,(5)(6)(7). While epidemiologic studies conducted in Taiwan support a role for high chronic arsenic exposure in atherosclerosis (8,9), data on other populations are scarce and results are inconclusive (8,9).…”

Section: Introductionmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease: A Systematic Review of the Epidemiologic Evidence

Navas‐Acien¹,

Sharrett²,

Silbergeld³

et al. 2005

American Journal of Epidemiology

362

207

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Arsenic exposure is a likely cause of blackfoot disease and a potential risk factor for atherosclerosis. The authors performed a systematic review of the epidemiologic evidence on the association between arsenic and cardiovascular outcomes. The search period was January 1966 through April 2005. Thirteen studies conducted in general populations (eight in high-arsenic areas in Taiwan, five in other countries) and 16 studies conducted in occupational populations were identified. Exposure was assessed ecologically in most studies. In Taiwan, relative risks comparing the highest arsenic exposure category with the lowest ranged from 1.59 to 4.90 for coronary disease, from 1.19 to 2.69 for stroke, and from 1.66 to 4.28 for peripheral arterial disease. In other general populations, relative risks ranged from 0.84 to 1.54 for coronary disease, from 0.69 to 1.53 for stroke, and from 0.61 to 1.58 for peripheral arterial disease. In occupational populations, relative risks ranged from 0.40 to 2.14 for coronary disease mortality and from 0.30 to 1.33 for stroke mortality. Methodologic limitations, however, limited interpretation of the moderate-to-strong associations between high arsenic exposure and cardiovascular outcomes in Taiwan. In other populations or in occupational settings, the evidence was inconclusive. Because of the high prevalence of arsenic exposure, carefully performed studies of arsenic and cardiovascular outcomes should be a research priority.

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Arterial Tissue of Arsenic, Selenium and Iron in Blackfoot Disease Patients

Cited by 12 publications

References 14 publications

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Arsenic Exposure and Cardiovascular Disease: An Updated Systematic Review

Arsenic Exposure and Cardiovascular Disease: A Systematic Review of the Epidemiologic Evidence

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