Arterial Tortuosity and Its Correlation with White Matter Hyperintensities in Acute Ischemic Stroke

Shang, Ke; Chen, Xiao; Chang, Cheng; Luo, Xiang; Xu, Shabei; Wang, Wei; Liu, Chenchen

doi:10.1155/2022/4280410

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Наши результаты отличаются от таковых в ранее опубликованном исследованиях K. Shang и соавт. [12], L. Yin и соавт. [13], J. Liu и соавт.…”

Section: Discussionunclassified

Carotid artery elongation (carotid dolichoarteriopathy): some features of the structure and hemodynamics

Golovin,

Berdalin,

Kudryavtsev

et al. 2024

Medicinskaâ vizualizaciâ

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The purpose of the study. Multimodal study of the state of the brachiocephalic arteries, with assessment of blood flow in the extra- and intracranial portions of the carotid arteries and brain perfusion, as well as the structure of the brain in patients with different types of elongation of the carotid arteries (ECA).Material and methods. The data of examinations of 79 patients (45 men (57.0%, average age – 61.0 ± 10.1 years) and 34 women (43.0%, 65.3 ± 13.6 years), average age 62.8 ± 11.8 years) during the year after ischemic stroke in posterior circulation were analyzed. ECA was verified by multispiral computed tomographic angiography (msCTA) in 44 patients (55.7% of the total number of cases), the control group was selected by gender and age with “case-control” elements and consisted of 35 (44.3%) patients without a mustache. All underwent msCTA of the thoracic aorta and BCA and CT perfusion examination, magnetic resonance imaging of the brain, duplex scanning of BCA and transcranial duplex scanning, transthoracic echocardiography, transcranial Doppler monitoring with microembolodetection.Results. We have registered intergroup differences, which can be divided into structural and functional. The former include: higher aortic arch location in patients with DCA: ThII – 6.3% vs. 0%, ThIII – 43% vs. 0%; ThIV – 28.1% vs. 62.9%* and ThV 21.9% vs. 37.1% (p < 0.0005); lower values of cervical spine height (114.70 ± 11.03 mm, vs. 120.46 ± 9.75 mm, p = 0.022), greater absolute length of the ICA (on the right – 101.32 ± 14.59 mm vs. 85.06 ± 12.07 mm, p < 0.0005; on the left – 100.00 ± 14.03 mm vs. 84.66 ± 12.63 mm, p < 0.0005). The presence of ECA was associated (p < 0.05) with a higher frequency of vertebral artery elongation. The severity of small vessel disease during MRI in individuals with ECA was slightly higher (not at the trend level, p = 0.076). Functional differences consisted in the registration of lower (p = 0.019) values of the end diastolic velocity in M1 of the middle cerebral arteries. The values of some perfusion indices in the blood supply of elongation arteries were lower than in persons without ECA. There were no cases of registration of microembolic signals in the ECA patients examined by us.Conclusion. In the individuals with ECA we examined, a complex of anatomical and hemodynamic features was determined, which, both individually and collectively, cannot lead to a decrease in the level of blood flow or be a source of arterio-arterial embolism in the carotid system, regardless of the configuration of the ICA.

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Section: Discussionunclassified

Carotid artery elongation (carotid dolichoarteriopathy): some features of the structure and hemodynamics

Golovin,

Berdalin,

Kudryavtsev

et al. 2024

Medicinskaâ vizualizaciâ

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“…While atherosclerosis itself involves vessel remodeling and structural changes, its direct link to arterial tortuosity remains less clear. Studies have explored the potential relationship between atherosclerosis and tortuosity, highlighting the complexity of their interactions [ 38 , 39 ]. Further research is needed to elucidate the specific mechanisms that underlie this intricate relationship.…”

Section: Reviewmentioning

confidence: 99%

Arterial Tortuosity Syndrome: Unraveling a Rare Vascular Disorder

Ekhator,

Devi,

Barker

et al. 2023

Cureus

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Arterial tortuosity syndrome (ATS) is a rare genetic disorder characterized by abnormal twists and turns of arteries, leading to cardiovascular complications. This syndrome, first reported around 55 years ago, is inherited in an autosomal recessive manner and affects both genders. ATS manifests primarily in childhood, with arterial abnormalities disrupting blood circulation, increasing shear stress, and causing complications, such as atherosclerosis and strokes. This article reviews the genetics, etiology, pathophysiology, clinical presentation, diagnosis, associated conditions, management, and challenges of ATS. The syndrome's genetic cause is linked to mutations in the SLC2A10 gene, affecting collagen and elastin synthesis. Arterial tortuosity, a complex phenomenon, arises from factors such as vessel elongation, anatomic fixation, and vessel diameter. ATS is one of many conditions associated with arterial tortuosity, including Marfan syndrome and Loeys-Dietz syndrome. Recent studies highlight arterial tortuosity's potential as a prognostic indicator for adverse cardiovascular events. Management requires a multidisciplinary approach, and surveillance and prevention play key roles. Despite challenges, advancements in understanding ATS offer hope for targeted therapies and improved patient care.

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“…Aging causes changes in the morphology of the aorta, leading to tortuosity, dilation, and stiffness (7,8), which affect the hemodynamics of the aorta, resulting in an increase in cardiac afterload, over-stretching of the aortic wall, and reducing coronary perfusion (9,10). Eventually, these morphological changes in the aorta could exacerbate atherosclerosis, increased the incidence of ischemic events such as stroke, and aneurysms (11,12). The progressive age-related changes in aortic anatomy can be measured with many imaging modalities, con rming the existence of signi cant sex differences in aortic diameter and tortuosity by using enhanced computed tomography (CT) and magnetic resonance imaging (MRI) (13,14).…”

Section: Introductionmentioning

confidence: 99%

Women are Prone to Age-Related aortic Stiffness

Meng

Cheng

Liu

et al. 2023

Preprint

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Background The morphology of the aorta changes with age, our study aims to investigate sex differences in the aortic aging by analyzing aortic diameter and tortuosity in different segments of aorta across the age spectrum, using enhanced CT imaging. Methods Between July 2021 and April 2022, a retrospective study screened patients with chest and abdomen contrast CT images. The outer edge-to-outer edge method was utilized to measure aortic diameters at five aortic levels, while arterial tortuosity of various segments was measured and calculated using imaging software. Mean values were compared at different age groups, including by sex, and correlation with age was determined. To validate the coherence of arterial elasticity and anticipated age-related arterial alterations, a subset of data from a previously published article in BMJ Open was extracted for the purpose of examining the correlation between age and arterial stiffness, stratified by sexes. Results 208 participants (56.6% men, mean age 60.13±16.33 years old, mean BMI 23.07±4.03 kg/m2, mean BSA 1.70±0.19 m2) were enrolled in this study. The BSA-adjusted aortic diameters showed a positive correlation with age in both sexes, but females demonstrated a more rapid increase in progressive aortic diameters throughout their lifespan than males. In the age groups of 60-69 and above 80 years old, males exhibited significantly larger L1 measurements than females. Conversely, in individuals over 80 years old, females displayed greater L3 values compared to their male counterparts. However, no sexual disparities were observed for L2, L4 and L5 across all ages. Females exhibited greater aortic tortuosity in the descending thoracic region compared to males across all age groups, whereas this sex-based distribution of aortic and abdominal tortuosity was only evident among individuals over 40 years old. The tortuosity of the aorta and descending thoracic aorta exhibits a marked increase with advancing age, particularly in females, while a non-significant linear correlation is observed between abdominal aortic tortuosity and age in both genders. BaPWV consistently increased with age in both males and females, but the increase was more significant in females. Although males initially had higher arterial stiffness, females surpassed them as they aged. Conclusions Patterns of vascular aging in aortic morphology differ between the sexes across the life course, with women experiencing more significant changes, especially in advanced age groups.

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Arterial Tortuosity and Its Correlation with White Matter Hyperintensities in Acute Ischemic Stroke

Cited by 9 publications

References 44 publications

Carotid artery elongation (carotid dolichoarteriopathy): some features of the structure and hemodynamics

Carotid artery elongation (carotid dolichoarteriopathy): some features of the structure and hemodynamics

Arterial Tortuosity Syndrome: Unraveling a Rare Vascular Disorder

Women are Prone to Age-Related aortic Stiffness

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