Arterial vascular disease in women

Vouyouka, Ageliki G.; Kent, K. Craig

doi:10.1016/j.jvs.2007.07.057

Cited by 72 publications

(52 citation statements)

References 89 publications

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“…However, women were more likely than men to survive into their 90s, given that the average lifespan of a woman is currently 5 to 7 years longer than that of a man. 5 In addition to a gender differential in the diagnosis of rAAA, there is also a gender differential in the percentage of patients who came to intervention for rAAA. Men were much more likely to undergo repair than women.…”

Section: Discussionmentioning

confidence: 99%

Gender trends in the repair of ruptured abdominal aortic aneurysms and outcomes

Mureebe

Egorova

McKinsey

et al. 2010

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

Gender trends in the repair of ruptured abdominal aortic aneurysms and outcomes

Mureebe

Egorova

McKinsey

et al. 2010

Journal of Vascular Surgery

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“…16 All haplotype analyses were adjusted for age, gender, body mass index, diabetes and atherosclerotic disease when appropriate. Because the natural history of hypertension and atherosclerotic disease differs in males and females, 17 analyses were carried out separately in males and females, and the Mantel-Haenszel statistic was used for testing the homogeneity of the results across gender.…”

Section: Discussionmentioning

confidence: 99%

Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease

et al. 2009

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Ghrelin is involved in several metabolic and cardiovascular processes. Recent evidence suggests its involvement in blood pressure regulation and hypertension. The aim of the study was to determine associations of single-nucleotide polymorphisms (SNPs) and haplotypes of the ghrelin gene (GHRL) with hypertension and atherosclerotic disease. Six GHRL SNPs (rs27647, rs26802, rs34911341, rs696217, rs4684677 and a -473G/A (with no assigned rsID)) were investigated in a sample of 1143 hypertensive subjects and 1489 controls of Caucasian origin. Both single-locus and haplotype association analyses were performed. In single-locus analyses, only the non-synonymous rs34911341 was associated with hypertension (odds ratio (OR)¼1.95 (95% confidence interval (CI): 1.26-3.02), P¼0.003). Six common haplotypes with frequency 41% were inferred from the studied GHRL SNPs, and their frequency distribution was significantly different between hypertensive subjects and controls (v 2 ¼12.96 with 5 d.f. (degree of freedom), P¼0.024). The effect of rs26802 was found to be significantly (P¼0.017) modulated by other GHRL SNPs, as its C allele conferred either an increased risk (OR¼1.30 (1.08-1.57), P¼0.005) or a decreased risk (OR¼0.50 (0.23-1.06), P¼0.07) of hypertension according to the two different haplotypes on which it can be found. No association of GHRL SNPs or haplotypes with atherosclerotic disease was observed. In conclusion, we observed statistical evidence for association between GHRL SNPs and risk of hypertension.

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“…2 This misperception has, in part, led to under-diagnoses and presentation with more advanced disease in women. [2][3][4][5][6][7] According to older reports, women are also more likely to undergo amputation and are less likely to have an arterial reconstruction as a first-line procedure. 4 The introduction of endovascular techniques as a valid alternative to open traditional surgery has improved the outcomes for women in other fields of vascular surgery.…”

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confidence: 99%