Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes

Atabek, Mehmet Emre; Kurtoğlu, Selim; Pirgon, Özgür; Baykara, Murat

doi:10.1016/j.diabres.2006.03.004

Cited by 63 publications

(50 citation statements)

References 31 publications

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“…Nevertheless, many questions remain unanswered such as the minimum time of exposure required for a clinical event to happen, the specific determinants in Type 1 DM for vascular damage, and whether the atherosclerotic process is already active in the prepubertal period. Studies on the CIMT in children and adolescents have conflicting results; some studies show an increase in the CIMT in diabetic patients, while others do not (31)(32)(33). The seemingly contradictory results may depend on the different ultrasound techniques used as well as on the different populations studied.…”

Section: Discussionmentioning

confidence: 82%

Impaired flow-mediated dilation response and carotid intima-media thickness in patients with type 1 diabetes mellitus with a mean disease duration of 4.1 years

Tácito

Pires

2017

Arch. Endocrinol. Metab.

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Objective: This study aimed at assessing the endothelial function in patients with Type 1 diabetes (T1DM) using flow-mediated dilation (FMD) response and carotid artery intima-media thickness (CIMT). Materials and methods: This study enrolled 32 T1DM patients (mean disease duration 4.1 years) and 28 age-matched controls (CTL Group). Endothelial function and CIMT were assessed with high-resolution ultrasound using standardized offline measurements. Results: FMD was significantly lower in patients in the T1DM Group (8.9 ± 3.2%) compared with those in the CTL Group (13.3 ± 4.3%; P-value < 0.0001). Similarly, CIMT differed significantly between T1DM patients (0.525 ± 0.03 mm) and controls (0.508 ± 0.03 mm; P-value = 0.041). Even though, the values are within the normal range for age. Conclusions: Patients with T1DM have impaired endothelial function characterized by reduced FMD when compared to controls. However, vascular remodeling as seen by increases in CIMT was not found in this study. Arch Endocrinol Metab. 2017;61(6):542-9

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Section: Discussionmentioning

confidence: 82%

Impaired flow-mediated dilation response and carotid intima-media thickness in patients with type 1 diabetes mellitus with a mean disease duration of 4.1 years

Tácito

Pires

2017

Arch. Endocrinol. Metab.

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“…Carotid IMT measurement using ultrasonography shows a good correlation with pathologic measurements, and this method can be repeated (4,19).…”

Section: Discussionmentioning

confidence: 99%

“…Increased carotid IMT is significantly related with known cardiovascular risk factors and may progress to a carotid plaque, which is a more severe atherosclerotic lesion (19,22). Human arteries are dynamic vessels that respond to different stimuli by re-modeling their own structure and size (22).…”

Section: Discussionmentioning

confidence: 99%

“…They underwent Doppler ultrasonography examinations using an SSA-660A ultrasound system (Xario, Toshiba Medical Systems Corporation, Tochigi, Japan) and a PLT-704AT Probe (Toshiba Medical Systems Corporation). The probe was placed 2 cm proximal to bifurcation of the right carotid artery and 2 cm distal to the separation of the deep branch of the right femoral artery, and evaluation of the arterial stiffness measurements was performed by a pre-defined method (19).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The assessment of relationship between bone mineral density and arterial stiffness in turkish women

Baykara

Öztürk²,

Elbüken³

2011

Diagn Interv Radiol

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“…There was no difference in total Hcy concentrations between T1D patients and controls [Atabek et al 2006;Rossi et al 2002;Pavia et al 2000].…”

Section: Homocysteine (Hcy)mentioning

confidence: 99%

Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

Lee

Patel

Jones

et al. 2015

Therapeutic Advances in Chronic Disease

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Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes mellitus (T1D). However, evidence of its risks and management is often extrapolated from studies in type 2 diabetic (T2D) patients or the general population. This approach is unsatisfactory given that the underlying pathology, demographics and natural history of the disease differ between T1D and T2D. Furthermore, with a rising life expectancy, a greater number of T1D patients are exposed to the cardiovascular (CV) risk factors associated with an ageing population. The aim of this review is to examine the existing literature around CVD in T1D. We pay particular attention to CVD prevalence, how well we manage risk, potential biomarkers, and whether the studies included the older aged patients (defined as aged over 65). We also discuss approaches to the management of CV risk in the older aged. The available data suggest a significant CVD burden in patients with T1D and poor management of CV risk factors. This is underpinned by a poor evidence base for therapeutic management of CV risk specifically for patients with T1D, and in the most relevant population -the older aged patients. We would suggest that important areas remain to be addressed, particularly exploring the risks and benefits of therapeutic approaches to CVD management in the older aged.

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Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes

Cited by 63 publications

References 31 publications

Impaired flow-mediated dilation response and carotid intima-media thickness in patients with type 1 diabetes mellitus with a mean disease duration of 4.1 years

Impaired flow-mediated dilation response and carotid intima-media thickness in patients with type 1 diabetes mellitus with a mean disease duration of 4.1 years

The assessment of relationship between bone mineral density and arterial stiffness in turkish women

Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

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