Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the rat

Müller, V.; Brummer, Daniela; Erhardt, W.; Henke, Julia; Kissler, H; Bauer, Michael; Amann, Kerstin; Ott, Rudolf; Hohenberger, Werner

doi:10.1111/j.1432-2277.2004.tb00517.x

Cited by 2 publications

(1 citation statement)

References 42 publications

(20 reference statements)

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“…It is reported that PVA with unrestricted inflow induces hepatic fibrosis [25]. To investigate whether the fibrosis and ductular reaction found in the PPVA + BDI group were caused by PV hypertension or anastomosis occlusion, the patency of the anastomosis, blood inflow, and PV pressure were examined.…”

Section: Resultsmentioning

confidence: 99%

Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

Jiang

Wei

et al. 2016

BioMed Research International

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Hepatic infarcts or abscesses occur after hepatic artery interruption. We explored the mechanisms of hepatic deprivation-induced acute liver injury and determine whether partial portal vein arterialization attenuated this injury in rats. Male Sprague-Dawley rats underwent either complete hepatic arterial deprivation or partial portal vein arterialization, or both. Hepatic ischemia was evaluated using biochemical analysis, light microscopy, and transmission electron microscopy. Hepatic ATP levels, the expression of hypoxia- and inflammation-associated genes and proteins, and the expression of bile transporter genes were assessed. Complete dearterialization of the liver induced acute liver injury, as evidenced by the histological changes, significantly increased serum biochemical markers, decreased ATP content, increased expression of hypoxia- and inflammation-associated genes and proteins, and decreased expression of bile transporter genes. These detrimental changes were extenuated but not fully reversed by partial portal vein arterialization, which also attenuated ductular reaction and fibrosis in completely dearterialized rat livers. Collectively, complete hepatic deprivation causes severe liver injury, including bile infarcts and biloma formation. Partial portal vein arterialization seems to protect against acute ischemia-hypoxia-induced liver injury.

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Section: Resultsmentioning

confidence: 99%

Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

Jiang

Wei

et al. 2016

BioMed Research International

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Hepatic Reperfusion in Rats: A New Model With Portal Arterialization in Studying Early Ischemia-Reperfusion Injury

Kruel

Fraga

Molin

et al. 2007

Transplantation Proceedings

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Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the rat

Abstract: Within the framework of liver transplantation, arterialisation of the portal vein in the case of non-

Cited by 2 publications

References 42 publications

Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

Hepatic Reperfusion in Rats: A New Model With Portal Arterialization in Studying Early Ischemia-Reperfusion Injury

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