Arterio-Venous Differences in the Components of the Fibrinolytic Enzyme System

Abstract

Summary1. The concentration of the major components of the fibrinolytic enzyme system was compared in venous and arterial blood samples from male subjects.2. The plasminogen activator concentration was higher in venous blood and the arterio-venous difference increased as its concentration rose, but the ratio of the arterial to venous level remained constant.3. No arterio-venous difference was found for anti-urokinase activity, antiplasmin, plasminogen and fibrinogen.4. It is concluded that venous blood determinations of the components of the fibrinolytic enzyme system reflect satisfactorily arterial blood levels.

Urokinase Inactivation Rate in the Rabbit: Effect of Circulatory Isolation of the Liver, Spleen and Kidneys

“…These results show the role and importance of the reticuloendothelial system (RES) (11) in the UK metabolism and allow the conclusion that the inactivation rate constant of UK might be derived mainly from the activity of the RES. Since the important role of the liver for the synthesis and clearance of coagulation factors is well known (3,10,14), it may be concluded that the liver is the essential organ for the regulation of both coagulation and fibrinolysis.…”

Hemostasis and Coagulation**Supported in part by NIH research grants HL09902 and HL07173 awarded by the National Heart, Lung, and Blood Institute, PHS/DHEW.

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Mechanisms of Deep Vein Thrombosis: A Review

“…Human blood contains six well characterized protease inhibitors and four of these, antithrombin III, C-I inactivator, alpha2-macroglobulin and alphaI-antitrypsin, have an inhibitory action on one or more coagulation factors (Ogston & Bennett 1977).…”