Arteriogenesis in Peripheral Arterial Disease

Palmer-Kazen, Ulrika; Wahlberg, Eric

doi:10.1080/713715232

Cited by 15 publications

(8 citation statements)

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“…For this group of patients there is an urgent need for alternative treatment strategies and several strategies are currently being tested to stimulate collateral artery growth. Arteriogenesis is defined as growth of preexisting arteriolar connections into true collateral arteries [55]. Recent investigations have shown that intramuscular vascular endothelial growth factor (VEGF) gene therapy can expedite or augment collateral artery development in CLI patients; this therapeutic approach is feasible, safe and effective [2,20].…”

Section: The Fate Of the Affected Limbmentioning

confidence: 99%

Critical Limb Ischemia: Definition and Natural History

Novo¹,

Coppola

Milio

2004

CDTCHD

128

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The term critical limb ischemia refers to a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene in one or both legs attributable to objectively proven arterial occlusive disease. Critical limb ischemia implies chronicity and is to be distinguished from acute limb ischemia. Its incidence is approximately 500 to 1000 per million year, with the highest rates among older subjects, smokers and diabetics. The rate of primary amputation ranges from 10% to 40%, and was performed only when no graftable distal vessels were present, or in neurologically impaired or hopelessly nonambulatory patients. Contrarily, in some highly specialized and aggressive centres about 90% of patients with CLI had an attempted revascularization. Furthermore, patients with critical limb ischemia have an elevated risk of future myocardial infarction, stroke and vascular death, 3-fold higher than patients with intermittent claudication. Therefore, due to its negative impact on the quality of life and the poor prognosis both in terms of limb salvage and survival, critical limb ischemia is a critical public health issue.

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Section: The Fate Of the Affected Limbmentioning

confidence: 99%

Critical Limb Ischemia: Definition and Natural History

Novo¹,

Coppola

Milio

2004

CDTCHD

128

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“…The number of patients presenting with severe limb ischemia, for which amputation is indicated, has increased in recent years, reflecting the aging population and dietary changes 1) . Alternative therapy includes the attempt to develop new collateral vessels.…”

Section: Introductionmentioning

confidence: 99%

Effects of Atorvastatin on Angiogenesis in Hindlimb Ischemia and Endothelial Progenitor Cell Formation in Rats

Matsumura

Fukuda

Kobayashi

et al. 2009

JAT

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“…In addition, this can be deduced from the fact that there is a clear relationship between the sequence variant on chromosome 9p and IA, in the pathogenesis of which atherosclerosis is not thought to play a major role. 12 The risk allele, rs10757278*G, may be involved in a common mechanism like vascular remodeling and/or repair, although this has been shown to be involved in stroke 24,25 and PAD 26 as well.…”

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confidence: 99%