Arteriographic Detection of Renovascular Disease in Potential Renal Donors: Incidence and Effect on Donor Surgery

Neymark, Edward; LaBerge, Jeanne M.; Hirose, Ryutaro; Melzer, Juliet S.; Kerlan, Robert K.; Wilson, Mark W.; Gordon, Roy L.

doi:10.1148/radiology.214.3.r00mr18755

Cited by 97 publications

(37 citation statements)

References 15 publications

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“…In a series of 716 potential renal donors for whom 80% of the angiograms were available for retrospective review, 6.6% had FMD. 25 In another series of 1862 patients, 3.8% had angiographic evidence of FMD. 22 A smaller but more recent study confirmed these results.…”

Section: Epidemiologymentioning

confidence: 95%

Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

Olin¹,

Gornik²,

Bacharach³

et al. 2014

Circulation

395

490

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Section: Epidemiologymentioning

confidence: 95%

Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

Olin¹,

Gornik²,

Bacharach³

et al. 2014

Circulation

395

490

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“…Others have suggested that FMD is more common than previously recognized. 5,6,9 The renal arteriograms of 1862 potential renal donors were examined, and FMD was found in 3.8%. 6 A similar prevalence was found in a more recent study of potential kidney donors.…”

Section: Clinical Perspective On P 3190mentioning

confidence: 99%

The United States Registry for Fibromuscular Dysplasia

et al. 2012

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Background-Fibromuscular dysplasia (FMD), a noninflammatory disease of medium-size arteries, may lead to stenosis, occlusion, dissection, and/or aneurysm. There has been little progress in understanding the epidemiology, pathogenesis, and outcomes since its first description in 1938. Methods and Results-Clinical features, presenting symptoms, and vascular events are reviewed for the first 447 patients enrolled in a national FMD registry from 9 US sites. Vascular beds were imaged selectively based on clinical presentation and local practice. The majority of patients were female (91%) with a mean age at diagnosis of 51.9 (SD 13.4 years; range, 5-83 years). Hypertension, headache, and pulsatile tinnitus were the most common presenting symptoms of the disease. Self-reported family history of stroke (53.5%), aneurysm (23.5%), and sudden death (19.8%) were common, but FMD in firstor second-degree relatives was reported only in 7.3%. FMD was identified in the renal artery in 294 patients, extracranial carotid arteries in 251 patients, and vertebral arteries in 82 patients. A past or presenting history of vascular events were common: 19.2% of patients had a transient ischemic attack or stroke, 19.7% had experienced arterial dissection(s), and 17% of patients had an aneurysm(s). The most frequent indications for therapy were hypertension, aneurysm, and dissection. Conclusions-In this registry, FMD occurred primarily in middle-aged women, although it presents across the lifespan.Cerebrovascular FMD occurred as frequently as renal FMD. Although a significant proportion of FMD patients may present with a serious vascular event, many present with nonspecific symptoms and a subsequent delay in diagnosis. (Circulation. 2012;125:3182-3190.)

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“…4,5 The mostcommon type of FMD is medial fibroplasia, and because of its benign clinical course, patients with this form of FMD can serve as renal donors. 2,3,6 The American Society of Transplant Physicians has provided guidelines on the suitability of kidney donors; however, there are no clear guidelines on the suitability of potential live-renal donors with asymptomatic FMD.…”

Section: Discussionmentioning

confidence: 99%

Successful Transplant of a Kidney With Fibromuscular Dysplasia Having Higher Glomerular Filtration Rate Than the Contralateral Kidney

Sun

Hong²,

Kim³

et al. 2012

Exp Clin Transplant

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Fibromuscular dysplasia is the second-most commonly encountered anatomic abnormality in potential renal donors. Normotensive patients with medial fibroplasia and low-grade lesions have been used as renal donors. However, no studies have reported the optimal choice of a kidney for donation where the kidney with fibromuscular dysplasia had a larger volume and a higher glomerular filtration rate than the unaffected side. Herein, we report a case of renal transplant using a kidney with fibromuscular dysplasia that had higher glomerular filtration rate than the normal side. After transplant, hypertension and abnormal serum creatinine did not occur in either the donor or the recipient during 12 months' follow-up.

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Arteriographic Detection of Renovascular Disease in Potential Renal Donors: Incidence and Effect on Donor Surgery

Abstract: In this population of potential renal donors, the arteriographic incidence of renovascular disease (10.9%) was higher than previously reported. Although renovascular abnormalities were mild, their detection influenced the plan for donor surgery in almost all patients.

Cited by 97 publications

References 15 publications

Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

The United States Registry for Fibromuscular Dysplasia

Successful Transplant of a Kidney With Fibromuscular Dysplasia Having Higher Glomerular Filtration Rate Than the Contralateral Kidney

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