Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis

J, Sloth-Nielsen; Guldager, B; Mouritzen, C; Lund, Elisabeth; Egeblad, M; Nørregaard, Ole; Jörgensen, Stefan; Jelnes, R

doi:10.1016/0002-9610(91)90172-a

Cited by 46 publications

(13 citation statements)

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“…Studies in patients with intermittent claudication have failed to demonstrate improvements in exercise measures, 823,824 anklebrachial index, 823,824 or digital subtraction angiograms with chelation. 825 The only RCT examining the effectiveness of chelation therapy on SIHD 826 studied 84 patients with stable angina and a positive treadmill test for ischemia. Those randomized to active therapy received weight-adjusted disodium EDTA chelation therapy for 3 hours per treatment, twice weekly for 15 weeks and then once monthly for an additional 3 months.…”

Section: Fihn Et Al Stable Ischemic Heart Disease: Full Text E407mentioning

confidence: 99%

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease

Fihn¹,

Gardin²,

Abrams³

et al. 2012

Circulation

737

441

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Section: Fihn Et Al Stable Ischemic Heart Disease: Full Text E407mentioning

confidence: 99%

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease

Fihn¹,

Gardin²,

Abrams³

et al. 2012

Circulation

737

441

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“…A review of this and earlier [3][4][5] studies led to the same conclusion, 6 although there was considerable dissent from that interpretation in subsequent correspondence. Despite strong advocacy by its exponents 1 based on testimonial evidence from subjects who appear to have benefited from the treatment, there is limited evidence for benefit of the therapy on vascular structure or function.…”

Section: Introductionmentioning

confidence: 71%

Effects of Chelation With Edta and Vitamin B Therapy on Nitric Oxide‐related Endothelial Vasodilator Function

Green

O'Driscoll

Maiorana

et al. 1999

Clin Exp Pharma Physio

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1. 'Chelation therapy' with EDTA is being frequently used in patients with cardiovascular disease, despite limited objective evidence of effectiveness. Depressed nitric oxide (.NO)-related endothelial function accompanies atherosclerosis, and even the vascular risk factors alone, and is improved by numerous interventions that also improve prognosis in vascular disease. 2. The aim of the present study was to determine the influence of chelation therapy with EDTA alone and EDTA in combination with B vitamins on endothelial function. 3. After a control series of saline infusions, we examined the effects of a series of EDTA infusions (1.5 g, 10 times over 6 weeks) in eight subjects with coronary artery disease. In addition, because EDTA is commonly supplemented by other components, particularly B group vitamins, we subsequently examined the effect of a similar series of vitamin-supplemented EDTA infusions. 4. Forearm blood flow (FBF) was assessed by plethysmography and graded intrabrachial infusions of the endothelium-dependent vasodilator acetylcholine (ACh) and the endothelium-independent dilator sodium nitroprusside (SNP). 5. There was no difference in vasodilation to either drug after EDTA alone compared with the control periods, but the response to ACh was augmented after combined therapy (P < 0.03, ANOVA). The latter was accompanied by a small but consistent mean (+/- SEM) fall in plasma homocysteine of 1.6 +/- 0.5 mumol/L (P < 0.05). 6. The selective increase in the vasodilator response to ACh after therapy with EDTA and several B group vitamins indicates that NO-related endothelial function was improved. The absence of response to EDTA alone suggests that the supplementary vitamins were necessary for this benefit, which may have been related to the accompanying decrease in plasma homocysteine. These results, along with the current interest in the possible cardioprotective effects of vitamins and the increasing administration of 'chelation therapy', call for more definitive studies on these aspects of 'alternative medicine'.

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“…Studies in patients with intermittent claudication and SIHD have failed to demonstrate improvements in exercise measures, 38,39 ankle-brachial index, 38,39 or digital subtraction angiograms with chelation. 40 A randomized controlled trial (RCT) examining the effect of chelation therapy on SIHD studied 84 patients with stable angina and a positive treadmill test for ischemia. 41 Those randomized to active therapy received weight-adjusted disodium EDTA chelation therapy for 3 hours per treatment, twice weekly for 15 weeks, and then once monthly for an additional 3 months.…”

Section: Diagnosis Ofmentioning

confidence: 99%

2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease

Fihn¹,

Blankenship²,

Alexander³

et al. 2015

The Journal of Thoracic and Cardiovascular Surgery

144

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Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis

Cited by 46 publications

References 0 publications

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease

Effects of Chelation With Edta and Vitamin B Therapy on Nitric Oxide‐related Endothelial Vasodilator Function

2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease

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