“…Among humans, atherosclerosis often occurs in diseases associated with hypercholesterolaemia-for example, in diabetes (Bowen et al, 1939), myxoedema (Bruger and Rosenkrantz, 1942), nephritis (Weinhouse, 1943), and hereditary xanthomatosis (Boas and Aldersberg, 1945). It would therefore appear that even in humans the presence of hypercholesterolaemia predisposes to the production of atherosclerosis, although, MEDICA4L JOURNAL in view of the common sites for atheroma, the additional factor of local stress and strain on the vessel wall must be considered.…”