Arteriosclerosis of the Aortic Sinuses

Enos, William F.; Beyer, James C.; Holmes, Robert H.

doi:10.1093/ajcp/39.5.506

Cited by 12 publications

(3 citation statements)

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“…Previous reports have documented frequent arteriosclerosis of the aortic sinuses of Valsalva. 11 Mild to moderate arteriosclerosis of the sinuses has been found from autopsies of hearts of soldiers dying on the field and more severe involvement has been seen in older autopsied patients, a mean of age 70. One may assume that atheromatous plaque of the wall of the aortic root results in ostial stenosis of the coronary artery, which is located at the upper part of the sinus of Valsalva.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Coronary Atherosclerotic Ostial Lesion with a Damping of the Pressure Tracing during Diagnostic Coronary Angiography

et al. 2016

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PurposeWhen performing coronary angiography (CAG), diagnostic catheter intubation to the ostium can cause damping of the pressure tracing. The aim of this study was to determine the predictors of atherosclerotic ostial stenosis in patients showing pressure damping during CAG.Materials and MethodsIn total, 2926 patients who underwent diagnostic CAG were screened in this study. Pressure damping was defined as an abrupt decline of the coronary blood pressure with a blunted pulse pressure after engagement of the diagnostic catheter. According to CAG and intravascular ultrasound (IVUS), we divided damped ostia into two groups: atherosclerotic ostial lesion group (true lesion group) and non-atherosclerotic ostium group (false lesion group). Clinical and angiographic characteristics were compared between the two groups.ResultsThe overall incidence of pressure damping was 2.3% (68 patients and 76 ostia). Among the pressure damped ostia, 40.8% (31 of 76 ostia) were true atherosclerotic ostial lesions (true lesion group). The true lesion group had more frequent left main ostial damping and more percutaneous coronary interventions (PCIs) performed on non-ostial lesions, compared to the false lesion group. On multivariate logistic regression analysis, left main ostial damping [hazard ratio (HR) 4.11, 95% confidence interval (CI) 1.24-13.67, p=0.021] and PCI on non-ostial lesion (HR 5.34, 95% CI 1.34-21.27, p=0.018) emerged as independent predictors for true atherosclerotic ostial lesions in patients with pressure damping.ConclusionLeft main ostial damping and the presence of a non-ostial atherosclerotic lesion may suggest a significant true atherosclerotic lesion in the coronary ostium.

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Section: Discussionmentioning

confidence: 99%

Prediction of Coronary Atherosclerotic Ostial Lesion with a Damping of the Pressure Tracing during Diagnostic Coronary Angiography

et al. 2016

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“…7 The reason for the apparent predilec¬ tion of women for ostial involvement is not obvious. Stoney and associates8 have found a ratio of females to males of 3/1.2 for involvement of visceral branches of the abdominal aorta by aortic intimai disease involving the ostia of these branches.…”

Section: Commentmentioning

confidence: 99%

Nonsyphilitic Coronary Ostial Stenosis

Barner¹

1977

Arch Surg

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“…In a previously reported series 1 – 6 ) , the incidence of ostial stenosis has varied between 0.13 and 2.7%, and in the majority of cases there is a coexisting disease in the multiple coronary vessels. It has been assumed to be atherosclerotic in origin 1 – 5 ) and excludes the coexisting homozygous familial hypercholesterolemia, otherwise normal coronary vessels in patients with syphilis 6 – 10 ) or other form of aortitis, congenital anomaly 11 ) and iatrogenic ostial stenosis 12 – 16 ) as a complication of coronary angiography or after coronary perfusion at the time of cardiac surgery 12 – 14 ) .…”

Section: Introductionmentioning

confidence: 99%