Arteriovenous malformation and dementia: A case report

Brucki, Sônia Maria Dozzi; Gomes, Samila Marissa Pinheiro

doi:10.1590/s1980-5764-2016dn1003012

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…These pathologic events might be the underlying mechanisms of bAVM-associated declines in sensory and motor functions as well as memory loss (see Fig 6D-L). Patients with bAVMs sometimes develop significant neurological disorders, including epilepsy, dementia, amyotrophic lateral sclerosis, or Parkinson's disease [57][58][59][60][61] ; therefore, further studies utilizing our approach can provide new insights into the pathogenesis of neurological diseases related to vascular malformation or vascular injury.…”

Section: Discussionmentioning

confidence: 99%

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice

Park

Kim

Huang³

et al. 2021

Annals of Neurology

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Objective: Brain arteriovenous malformations (bAVMs) are a leading cause of hemorrhagic stroke and neurological deficits in children and young adults, however, no pharmacological intervention is available to treat these patients. Although more than 95% of bAVMs are sporadic without family history, the pathogenesis of sporadic bAVMs is largely unknown, which may account for the lack of therapeutic options. KRAS mutations are frequently observed in cancer, and a recent unprecedented finding of these mutations in human sporadic bAVMs offers a new direction in the bAVM research. Using a novel adeno-associated virus targeting brain endothelium (AAV-BR1), the current study tested if endothelial KRAS G12V mutation induces sporadic bAVMs in mice. Methods: Five-week-old mice were systemically injected with either AAV-BR1-GFP or -KRAS G12V . At 8 weeks after the AAV injection, bAVM formation and characteristics were addressed by histological and molecular analyses. The effect of MEK/ERK inhibition on KRAS G12V -induced bAVMs was determined by treatment of trametinib, a US Food and Drug Administration (FDA)-approved MEK/ERK inhibitor. Results: The viral-mediated KRAS G12V overexpression induced bAVMs, which were composed of a tangled nidus mirroring the distinctive morphology of human bAVMs. The bAVMs were accompanied by focal angiogenesis, intracerebral hemorrhages, altered vascular constituents, neuroinflammation, and impaired sensory/cognitive/motor functions. Finally, we confirmed that bAVM growth was inhibited by trametinib treatment. Interpretation: Our innovative approach using AAV-BR1 confirms that KRAS mutations promote bAVM development via the MEK/ERK pathway, and provides a novel preclinical mouse model of bAVMs which will be useful to develop a therapeutic strategy for patients with bAVM.

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Section: Discussionmentioning

confidence: 99%

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice

Park

Kim

Huang³

et al. 2021

Annals of Neurology

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“…Each anomaly is characterized by its unique anatomy, pathophysiology, clinical behavior, and approach to management [1][2]. They are among the most complicated diagnostic and therapeutic enigmas in the area of the head and neck [3][4]. Hence, developing a classification system that will address both diagnostic and therapeutic problems is of utmost importance.…”

Section: Discussionmentioning

confidence: 99%

“…In 1982, Mulliken and Glowacki introduced into two main categories a biological classification based on their clinical appearance, histopathologic characteristics, and biological behavior: tumors and malformations [1,5]. This classification was later redefined by Mulliken and Young, and approved in 1996 by the International Society for the Study of Vascular Anomalies (ISSVA) [3,6]. Now, it has recently been revised at the 20th ISSVA Workshop in Melbourne Australia, April 2014 [6].…”

Section: Discussionmentioning

confidence: 99%

“…Hemorrhage is the most common symptom but other symptoms include headache, seizures, stroke-like symptoms, and ischemic stroke. Within the literature, cognitive results are rarely published, with some indications of a progressive course among case series reports [ 3 ]. Hence, we report here a case of AVMs in a 62-year-old South Indian man diagnosed on a retinue dental checkup using ultrasonography (USG) with color Doppler application and discuss the need for timely care for this case.…”

Section: Introductionmentioning

confidence: 99%

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Arteriovenous Malformation of the Lip: A Rare Case Report

Hameed¹,

Alnafisah²

2020

Cureus

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Vascular malformation (VM) consists of a group of tumors that emerge from vascular origin caused by vascular angiovascular or lymphoproliferation. Arteriovenous malformations (AVMs) contribute high-flow, creating direct vein artery contact without regular capillary network. AVMs are present at birth or in congenital. Acquired AVMs occur later in life due to hormonal changes or trauma, and acquired AVMs in oral cavity are very rare. AVMs are persistent and progressive in nature when present, can represent a lethal, causing significant blood loss, and an incomplete resection frequently leads to a recurrence of the lesion. We present a rare case of a congenital AVM diagnosed on retinue dental checkup using color doppler ultrasonography (USG) in a 62-year-old man from South India.

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“…The International Society for the Study of Vascular Anomalies (ISSVA) developed and revised a classification system that includes histologic features, anatomic, and embryologic, integrating genetic advances in the interpretation of vascular anomalies [2,3].…”

Section: Case Presentationmentioning

confidence: 99%

Accident due to Incorrect Selection of Diode Laser Technique in the Treatment of Oral Venous Malformation

Mohsen,

Migliau,

Pergolini

et al. 2023

Case Reports in Dentistry

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Venous malformation (VM) originates from a congenital venous network disorder, configuring about 40% of the vascular anomalies that occur in the head and neck region. The usage of diode lasers in the treatment of VM is associated with various advantages, such as short operating time and few postoperative complications. Nevertheless, for larger and deeper VM treatment, it may require more than one session for the complete resolution of the lesion. Laser surgery for oral VM may induce heat accumulation due to excessive irradiation causing adverse events postoperatively, including pain and ulcer formation with scarring. In this clinical case, it was recommended to use the leopard technique (LT) to reduce the lesion size, evaluate the remaining unhealed lesion, and apply different laser techniques to obtain the complete resolution of the lesion.

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Arteriovenous malformation and dementia: A case report

Abstract: Arteriovenous malformation (AVM) is a congenital lesion commonly associated with intracranial hemorrhage. We describe a woman with an AVM (Spetzler-Martin grade V) and presenile progressive dementia. The association between AVM and cognition is discussed.

Cited by 3 publications

References 10 publications

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice

Arteriovenous Malformation of the Lip: A Rare Case Report

Accident due to Incorrect Selection of Diode Laser Technique in the Treatment of Oral Venous Malformation

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