A 42-year-old Caucasian female presented with extreme pain of the right mandible and paresthesia of her right lower lip from the commissure to the midline. The patient reported that sudden severe pain began 4 months earlier in the right mandible. Consultation with a private dentist for the pain resulted in the initiation of endodontic therapy for tooth #30. Subsequent to the completion of root canal treatment on tooth #30, the pain increased and the paresthesia began. Both the pain and paresthesia were nonresponsive to a short course of steroids and antibiotics. Tooth #30 was extracted 1 month prior to presentation. Following the extraction, the pain and paresthesia worsened and a ''swishing'' sound developed in her right ear. Evaluation by otolaryngology was negative. Intraoral and extraoral examinations were unremarkable except for the right lower lip paresthesia. Panoramic ( Fig. 1), occlusal ( Fig. 2) and periapical radiographs (Fig. 3) were taken at the time of presentation.
Differential DiagnosisThe panoramic radiograph revealed a poorly defined radiolucent area extending from the right mandibular second premolar area to the right mandibular third molar. There was evidence of widening of the mandibular canal (Fig. 1). The cross sectional occlusal radiograph revealed a radiolucent area predominantly in the mandibular right first and second molar region. There was no evidence of cortical expansion or periosteal reaction (Fig. 2). A periapical radiograph revealed a poorly defined radiolucent area extending from the right mandibular second premolar to the right mandibular third molar area. Evidence of the recent extraction of #30 was present. There was no evidence of root resorption, but the lamina dura was only partially intact on both the second premolar and the second molar (Fig. 3). An axial computed tomographic image revealed an osteolytic lesion distal to the right mandibular second premolar. There was fenestration of the lingual cortex without evidence of expansion of either cortex. The CT scan was interpreted by her physicians as possibly representing ''abscess formation'' (Fig. 4). Although an acute infection of pulpal origin can produce poorly defined radiolucencies of bone and symptoms of pain and paresthesia, [1] an infectious etiology was ruled out when symptoms failed to resolve after extraction, antibiotics and corticosteroid therapy. Inflammation and infection related paresthesia is thought to be produced by mechanical pressure and ischemia associated with the inflammatory process [2].Based on the clinical history and radiographic findings at the time of presentation, a differential diagnosis was formulated that included metastatic carcinoma, lymphoma, peripheral nerve sheath tumor and vascular malformation.