Arteriovenous Malformations and Vasospasm

Synopsis In a recently-reported NINDS-funded randomized clinical trial, the first for brain arteriovenous malformations, limited to those discovered not having bled, medical management alone was found superior to medical management plus intervention to eradicate brain arteriovenous malformations. The trial was halted at the recommendation of the NINDS-appointed Data and Safety Management Board after 226 randomizations and a mean follow-up of 3.3 years due to a disparity favoring the medical arm (HR=3.41 95%CI: 1.72-6.76). Patients eligible for the trial were selected by the interventional teams as suitable for lesion eradication. The initial sample size of 800 and follow-up plans for mean 7 years were lowered and shortened, respectively, by the outcome data. An application for extended follow-up was given poor priority scores by a NINDS Study Section and Council due to estimations the disparities in outcomes would not change significantly.

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Cerebral Vasospasms After Intraventricular Hemorrhage From an Arteriovenous Malformation -Case Report-

Yokobori

Watanabe

Nakae

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 33-year-old female presented with a rare case of severe vasospasm following the rupture of an arteriovenous malformation (AVM) without subarachnoid hemorrhage. Initial computed tomography (CT) revealed a subcutaneous hematoma and cast formation of intraventricular clots without the deposition of subarachnoid blood in any basal cistern. Cerebral angiography revealed a small AVM located in the right parietal lobe without aneurysmal formations. Repeat CT demonstrated no evidence of subarachnoid clots expected with the presence of intraventricular clots and she was transferred to a general ward. She suffered sudden onset of motor aphasia and disturbance of consciousness on Day 17 after the hemorrhage. Magnetic resonance imaging indicated diffuse cortical infarction and subsequent magnetic resonance angiography revealed severe narrowing of the bilateral internal carotid arteries. Three-dimensional CT angiography on the same day indicated similar findings. She was transferred back to the intensive care unit for critical treatment. However, she suffered persistent mild right hemiparesis and motor aphasia. The characteristic features of vasospasm after intraventricular hemorrhage from AVMs are delayed onset, acute deterioration of consciousness, female predominance, and localization to the bilateral internal carotid arteries. Treatment of patients with AVM rupture should consider the risk of severe vasospasm, even if there is no subarachnoid clot.

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Arteriovenous Malformations and Vasospasm

Cited by 3 publications

References 5 publications

Vasospasm and cerebral infarction following isolated intraventricular hemorrhage

Vasospasm and cerebral infarction following isolated intraventricular hemorrhage

Management of Unbled Brain Arteriovenous Malformation Study

Cerebral Vasospasms After Intraventricular Hemorrhage From an Arteriovenous Malformation -Case Report-

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