Arteriovenous Malformations: How We Changed Our Practice

Griessenauer, Christoph J.; Dolati, Parviz; Thomas, Ajith J.; Ogilvy, Christopher S.

doi:10.1007/978-3-319-27315-0_14

Cited by 1 publication

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“…The biological response to the increase in venous pressure and the collateral increase in venous pulsatility can be an enlargement, thickening, and stiffening of veins, which is often observed in pAVM patients. 18 Our model shows that the extent of this phenomenon strongly depends on the size (d shunt ) of the shunting vessel: the larger the shunt, the higher the reduction of distal perfusion. If d shunt is comparable to the surrounding systemic arteries, distal perfusion cannot be maintained.…”

Section: Hemodynamic Parameters In Type I Pavmsmentioning

confidence: 77%

Hemodynamic Characterization of Peripheral Arterio-venous Malformations

et al. 2017

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Peripheral arterio-venous malformations (pAVMs) are congenital vascular anomalies that require treatment, due to their severe clinical consequences. The complexity of lesions often leads to misdiagnosis and ill-planned treatments. To improve disease management, we developed a computational model to quantify the hemodynamic effects of key angioarchitectural features of pAVMs. Hemodynamic results were used to predict the transport of contrast agent (CA), which allowed us to compare our findings to digital subtraction angiography (DSA) recordings of patients. The model is based on typical pAVM morphologies and a generic vessel network that represents realistic vascular feeding and draining components related to lesions. A lumped-parameter description of the vessel network was employed to compute blood pressure and flow rates. CA-transport was determined by coupling the model to a 1D advection-diffusion equation. Results show that the extent of hemodynamic effects of pAVMs, such as arterial steal and venous hypertension, strongly depends on the lesion type and its vascular architecture. Dimensions of shunting vessels strongly influence hemodynamic parameters. Our results underline the importance of the dynamics of CA-transport in diagnostic DSA images. In this context, we identified a set of temporal CA-transport parameters, which are indicative of the presence and specific morphology of pAVMs.

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Section: Hemodynamic Parameters In Type I Pavmsmentioning

confidence: 77%