Arteriovenous malformations of the corpus callosum: Pooled analysis and systematic review of literature

Abstract

Background:Arteriovenous malformations (AVMs) of the corpus callosum (CC) are rare entities. We performed a systematic review of the available literature to better define the natural history, patient characteristics, and treatment options for these lesions.Methods:A MEDLINE, Google Scholar, and The Cochrane Library search were performed for studies published through June 2015. Data from all eligible studies were used to examine epidemiology, natural history, clinical features, treatment strategies, and outcomes of patients with CC-AVMs. A systematic review and pooled analysis of the literature were performed.Results:Our search yielded 37 reports and 230 patients. Mean age at presentation was 26.8 years (±13.12 years). AVMs were most commonly located in the splenium (43%), followed by the body (31%), and then the genu (23%) of the CC. A Spetzler-Martin grade of III was the most common (37%). One hundred eighty-seven (81.3%) patients presented with hemorrhage, 91 (40%) underwent microsurgical excision, and 87 (38%) underwent endovascular embolization. Radiosurgery was performed on 57 (25%) patients. Complete obliteration of the AVM was achieved in 102 (48.1%) patients and approximately twice as often when microsurgery was performed alone or in combination with other treatment modalities (94% vs. 49%; P < 0.001). Mean modified Rankin Scale (mRS) at presentation was 1.54 and mean mRS at last follow-up was 1.31. This difference was not statistically significant (P = 0.35).Conclusion:We present an analysis of the pooled data in the form of a systematic review focusing on management of CC-AVMs. This review aims to provide a valuable tool to aid in decision making when dealing with this particular subtype of AVM.

Endovascular treatment of brain arteriovenous malformations involving the anterior cerebral artery

“…Generally speaking, the MCA only compensates for the pial branches of ACA. Some of the BAVMs can occur specifically in the supplying area of ACA, exhibiting a variety of vascular architectures (14). However, to date, to the best of our knowledge, there is no detailed classification of this specific type of BAVM.…”

Interhemispheric gravity‐assisted approach for microsurgical resection of a splenium arteriovenous malformation

“…The parietal interhemispheric approach employing gravity retraction with skeletonization of bridging veins provides an excellent operative window for microsurgical resection of these lesion (Figure 1 , Video S1 ). 1 …”