Artery Buckling: New Phenotypes, Models, and Applications

Han, Hugang; Chesnutt, Jennifer K.W.; Garcia, Justin R.; Liu, Qin; Wen, Qi

doi:10.1007/s10439-012-0707-0

Cited by 79 publications

(67 citation statements)

References 118 publications

(181 reference statements)

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“…This is the major reason, why the reference configurations of the loading scenarii were chosen to induce a partial loading (λa = 1.3, P = 100 mmHg for scenario 1, λa = 1.6, P = 20 mmHg for scenario 2): in fact the fibers appeared close to engagement or partially engaged. Another reason for this choice of loading originated in the need to prevent the potential buckling of the samples at high pressure and low axial stretch [22], which would have disabled the analysis of macroscopic and microscopic kinematics. As concerns the interpretation of the adventitial microstructure using a tensegrity model, it must be mentioned that, at this stage of knowledge about the arterial microstructure, its physical validity is conditioned by the verification of several assumptions.…”

Section: Stack Of Imagesmentioning

confidence: 99%

“…The reference configurations included partial loading (λa = 1.3, P = 100 mmHg for scenario 1, λa = 1.6, P = 20 mmHg for scenario 2) for several reasons. First, we chose to post-process adventitial collagen images characterized by a sufficient degree of decrimping, hence avoiding imprecisions in the Fourier analysis of the global orientations of the fibers (at the bundle scale); second this choice prevented the potential buckling of the samples at high pressure and low axial stretch [22], which could have impaired the analysis of macroscopic and microscopic kinematics.…”

Section: Loading Scenario and Data Acquisitionmentioning

confidence: 99%

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Kinematics of collagen fibers in carotid arteries under tension-inflation loading

Krasny

Magoariec

Morin

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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Biomechanics of the extracellular matrix in arteries determines their macroscopic mechanical behavior. In particular, the distribution of collagen fibers and bundles plays a significant role. Experimental data showed that in most arterial walls there are preferred fiber directions. However, the realignment of collagen fibers during tissue deformation is still controversial: whilst authors claim that fibers should undergo affine deformations, others showed the contrary. In order to have an insight about this important question of affine deformations at the microscopic scale, we measured the realignment of collagen fibers in the adventitia layer of carotid arteries using multiphoton microscopy combined with an unprecedented Fourier based method. We compared the realignment for two types of macroscopic loading applied on arterial segments: axial tension under constant pressure (scenario 1) and inflation under constant axial length (scenario 2). Results showed that, although the tissue underwent macroscopic stretches beyond 1.5 in the circumferential direction, fiber directions remained unchanged during scenario 2 loading. Conversely, fibers strongly realigned along the axis direction for scenario 1 loading. In both cases, the motion of collagen fibers did not satisfy affine deformations, with a significant difference between both cases: affine predictions strongly under-estimated fiber reorientations in uniaxial tension and over-estimated fiber reorientations during inflation at constant length. Finally, we explained this specific kinematics of collagen fibers by the complex tension-compression interactions between very stiff collagen fibers and compliant surrounding proteins. A tensegrity representation of the extracellular matrix in the adventitia taking into account these interactions was proposed to model the motion of collagen fibers during tissue deformation.

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Section: Stack Of Imagesmentioning

confidence: 99%

Section: Loading Scenario and Data Acquisitionmentioning

confidence: 99%

Kinematics of collagen fibers in carotid arteries under tension-inflation loading

Krasny

Magoariec

Morin

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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“…This lateral load can balance with the axial tension when the pressure is high enough and the artery reaches equilibrium at the bent shape, thus bifurcation occurs and the artery buckles [1][2][3]. Artery buckling could be a possible mechanism for the tortuous arteries observed often in aged populations and in patients with cardiovascular diseases [4][5][6]. The loss of stability could alter blood flow and arterial wall stress [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Khalafvand

Han

2015

Journal of Biomechanical Engineering

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It has been shown that arteries may buckle into tortuous shapes under lumen pressure, which in turn could alter blood flow. However, the mechanisms of artery instability under pulsatile flow have not been fully understood. The objective of this study was to simulate the buckling and post-buckling behaviors of the carotid artery under pulsatile flow using a fully coupled fluid-structure interaction (FSI) method. The artery wall was modeled as a nonlinear material with a two-fiber strain-energy function. FSI simulations were performed under steady-state flow and pulsatile flow conditions with a prescribed flow velocity profile at the inlet and different pressures at the outlet to determine the critical buckling pressure. Simulations were performed for normal (160 ml/min) and high (350 ml/min) flow rates and normal (1.5) and reduced (1.3) axial stretch ratios to determine the effects of flow rate and axial tension on stability. The results showed that an artery buckled when the lumen pressure exceeded a critical value. The critical mean buckling pressure at pulsatile flow was 17-23% smaller than at steady-state flow. For both steady-state and pulsatile flow, the high flow rate had very little effect (<5%) on the critical buckling pressure. The fluid and wall stresses were drastically altered at the location with maximum deflection. The maximum lumen shear stress occurred at the inner side of the bend and maximum tensile wall stresses occurred at the outer side. These findings improve our understanding of artery instability in vivo.

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“…9). Extension of these concepts to bio-medical applications 10 and to microand nano-scale systems (e.g., Langmuir-Blodgett molecular films, 11,12 molecular graphene sheets, 13 viral capsids, 14 supercoiled DNAs, 15 lipid membranes 16,17 ) have also been developed. While the onset of a buckling instability (and the following post-buckling behavior) is often considered a harmful event, engineers have learned how to turn drawbacks into opportunities.…”

Section: A Motivationmentioning

confidence: 99%

Peptide-induced membrane curvature in edge-stabilized open bilayers: A theoretical and molecular dynamics study

Pannuzzo

Raudino

Böckmann

2014

The Journal of Chemical Physics

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Peptide-or protein-induced curvatures of lipid membranes may be studied in molecular dynamics (MD) simulations. In these, membranes are usually modeled as infinitely extended bilayers by using periodic boundary conditions. However, the enforced periodicity results in an underestimation of the bending power of peptides, unless the patch size is much larger than the induced curvature radii. In this letter, we propose a novel approach to evaluate the bending power of a given distribution and/or density of peptides based on the use of flat open-edged lipid patches. To ensure long-lived metastable structures, the patch rim is stabilized in MD simulations by a local enrichment with short-chain lipids. By combining the theory of continuum elastic media with MD simulations, we prove that open-edged patches evolve from a planar state to a closed vesicle, with a transition rate that strongly depends on the concentration of lipid soluble peptides. For close-to-critical values for the patch size and edge energy, the response to even small changes in peptide concentration adopts a transition-like behavior (buckling instability). The usage of open-edged membrane patches amplifies the bending power of peptides, thereby enabling the analysis of the structural properties of membrane-peptide systems. We applied the presented method to investigate the curvature induced by aggregating β -amyloid peptides, unraveling a strong sensitivity of membrane deformation to the peptide concentration.

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Artery Buckling: New Phenotypes, Models, and Applications

Cited by 79 publications

References 118 publications

Kinematics of collagen fibers in carotid arteries under tension-inflation loading

Kinematics of collagen fibers in carotid arteries under tension-inflation loading

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Peptide-induced membrane curvature in edge-stabilized open bilayers: A theoretical and molecular dynamics study

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