Artery phantoms for intravascular optical coherence tomography: healthy arteries

Bisaillon, Charles-Etienne; Dufour, M.; Lamouche, Guy

doi:10.1364/boe.2.002599

Cited by 23 publications

(28 citation statements)

References 15 publications

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“…46)]. In the future, it may be possible to improve the elastic modulus through the addition of pure PDMS to the curing agent 38,47 when fabricating one or more layers. Additionally, our phantom could be expanded to mimic absorption properties of tissue through the use of molecular absorbers 48 or dyes.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the heat lamp causes partial curing (i.e., semi-curing); Bisaillon et al also demonstrates a method using heat curing to achieve uniformly thick layers, though their process is not amenable to fabricate nonluminal organs. 38 The entire process can be repeated to build additional layers with the same or different optical properties after curing in an oven for 10 min at 60°C. We successfully spin coated up to 15 layers with differing thicknesses and optical properties in a single mold (data not shown).…”

Section: Spin Coating (D)mentioning

confidence: 99%

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Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

et al. 2014

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Abstract. We describe a combination of fabrication techniques and a general process to construct a threedimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, and functional characteristics of a cancerous bladder. The phantom also includes features that are recognizable in white light (i.e., the visual appearance of blood vessels), making it suitable to emulate the bladder for emerging white light þ optical coherence tomography (OCT) cystoscopies and other endoscopic procedures of large, irregularly shaped organs. The fabrication process has broad applicability and can be generalized to OCT phantoms for other tissue types or phantoms for other imaging modalities. To this end, we also enumerate the nuances of applying known fabrication techniques (e.g., spin coating) to contexts (e.g., nonplanar, 3-D shapes) that are essential to establish their generalizability and limitations. We anticipate that this phantom will be immediately useful to evaluate innovative OCT systems and software being developed for longitudinal bladder surveillance and early cancer detection. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%

Section: Spin Coating (D)mentioning

confidence: 99%

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

et al. 2014

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“…15,18,19 Firstly, the PDMS base material (SYLGARD 184, Dow Corning) was mixed homogeneously with TiO 2 Nano powder (TiO 2 , T104939, Aladdin). Seven di®erent particle concentrations from 0.3% to 14% were used in this study.…”

Section: Materials Selectionmentioning

confidence: 99%

“…Left in an oven with the 90 C environment for 3 h, a piece of solid material can be obtained for subsequent operations. Finally, the singlescattering model 15,18,19 was used to acquire the total attenuation coe±cient of the materials. The relationship between the attenuation coe±cient and the concentration of TiO 2 particle material is shown in Fig.…”

Section: Materials Selectionmentioning

confidence: 99%

Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device

Cao

Ding

et al. 2018

J. Innov. Opt. Health Sci.

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Optical coherence tomography (OCT) has been widely applied to the diagnosis of eye diseases during the past two decades. However, valid evaluation methods are still not available for the clinical OCT devices. In order to assess the axial resolution of the OCT system, standard model eyes with micro-scale multilayer structure have been designed and manufactured in this study. Mimicking a natural human eye, proper Titanium dioxide (TiO 2 ) materials of particles with di®erent concentrations were selected by testing the scattering coe±cient of PDMS phantoms. The arti¯cial retinas with multilayer¯lms were fabricated with the thicknesses from 9.5 to 30 micrometers using spin coating technology. Subsequently, standard OCT model eyes were accomplished by embedding the retina phantoms into the arti¯cial frames of eyes. For ease of measurement processing, a series of model eyes were prepared, and each contained¯lms with three kinds of thicknesses. Considering the traceability and accuracy of the key parameters of the ** Corresponding authors. This is an Open Access article published by World Scienti¯c Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited. Vol. 11, No. 3 (2018) standard model eyes, the thicknesses of multilayer structures were veri¯ed using Thickness Monitoring System. Through the experiment with three di®erent OCT devices, it demonstrated the model eyes fabricated in this study can provide an e®ective evaluation method for the axial resolution of an ophthalmic OCT device. Journal of Innovative Optical Health Sciences

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“…The optical tissue phantoms used in this experiment were described previously. 28 The artery-like phantoms were composed of cylindrical layers successively deposited on lathe setup. Each layer was made from a silicone matrix with specific concentrations of alumina and carbon black to provide specific absorption and scattering properties.…”

Section: Plaque Classificationmentioning

confidence: 99%

Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

et al. 2016

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, "Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks," J. Med. Imag. 3(2), 024501 (2016) Abstract. Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame averaging. There was no effect of tissue depth or oblique imaging on pullback parameter estimates. The method's performance was assessed in comparison with observer-defined standards using clinical pullback data. Values (calcium 3.58 AE 1.74 mm −1 , lipid 9.93 AE 2.44 mm −1 , and fibrous 1.96 AE 1.11 mm −1 ) were consistent with previous measurements obtained by other means. Using optical parameters (μ t , hIi, I 0 ), we achieved feature space separation of plaque types and classification accuracy of 92.5 AE 3%. Despite the rapid z motion and varying incidence angle in pullbacks, the proposed computational pipeline appears to work as well as a more standard "stationary" approach.

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Artery phantoms for intravascular optical coherence tomography: healthy arteries

Cited by 23 publications

References 15 publications

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device

Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

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