Artesunate attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through inhibition of pro-inflammatory cytokines and pro-inflammatory chemokines

Jiang, Weiwei; Cen, Yanyan; Song, Yi; Li, Pan; Qin, Rongxin; Liu, Chao; Zhao, Yibo; Zheng, Jie; Zhou, Hong

doi:10.1016/j.phymed.2016.06.004

Cited by 62 publications

(45 citation statements)

References 26 publications

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“…Artemisinin and its derivatives, such as artesunate and dihydroartemisinin, have been reported to have immunity-regulating effects [23,40]. However, the underlying mechanism remains poorly defined.…”

Section: Discussionmentioning

confidence: 99%

Dihydroartemisinin exerts multiple effects in ameliorating CNS inflammation by enhancing AXL signaling in microglia from mouse model of multiple sclerosis

Ran

Liu

et al. 2020

Preprint

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Background: Dihydroartemisinin (DHA), a bioactive sesquiterpenoids originated from Artemisia annua L. , extensively applied in traditional medicine for the treatment of multiple autoimmune diseases. AXL, shown to dampen the immune response, reduce pro-inflammatory cytokine secretion, clear apoptotic cells and debris in Multiple sclerosis (MS), suggesting that it plays a role in disease pathogenesis. Thus, aiming to investigated whether DHA ameliorates experimental autoimmune encephalomyelitis (EAE) by modulating AXL signaling, we determined it both in vivo and vitro studies.Methods: Firstly, female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein MOG 35-55 peptide emulsified in complete Freund’s adjuvant and injected with pertussis toxin on day 0 and 2. Mice were monitored daily with DHA for clinical signs of disease and analyzed for pathology and ethology during the acute phase of disease. Moreover, functions of Immunological responses were assessed by flow cytometry and fluorescence microscope, chemokine were determined through ELISA and Transwell assay, proteins were monitored by Western blot and genes expression were explored by PCR.Results: Results identified mice immunized with MOG35-55 had a significantly more severe acute phase of EAE than negative control mice. In contrast, DHA treated mice had slighter spinal cord lesions with less inflammatory cuffs, less demyelination, and slighter axonal damage than EAE mice. Furthermore, by using gait analysis, DHA obviously ameliorated clinical features in EAE mice. Strikingly, DHA reduced the chemotactic ability of microglia, promoted the differentiation of T cells into Treg cells and enhanced the phagocytic ability of microglia. Moreover, DHA up-regulated expression of AXL, SOCS3, and STAT1 phosphorylation. By contrast, no significant differences were noted in these responses above by using SGI7079, inhibitor of AXL. Furthermore, DHA up-regulated expression of AXL, SOCS3, and STAT1 phosphorylation and enhanced the phagocytic ability of microglia when IFNAR was activated by IFN-β，however, no significant differences were noted in these responses above by using Fludarabine, inhibitor of STAT1 phosphorylation.Conclusions: Taken together, the present study demonstrated that DHA exerts multiple effects in ameliorating neuroinflammation process by enhancing AXL signaling that depending on modulating STAT1/SOCS3 axis in EAE, a mouse model of multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Dihydroartemisinin exerts multiple effects in ameliorating CNS inflammation by enhancing AXL signaling in microglia from mouse model of multiple sclerosis

Ran

Liu

et al. 2020

Preprint

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“…Jiang et al showed that artesunate, a derivate of artemisinin from sweet wormwood, attenuated formation of atherosclerosis lesion via reduction of vascular inflammation in high-fat fed ApoE −/− mice. When combined with rosuvastatin, a lipid-lowering agent, artesunate produced a greater attenuation of atherosclerosis compared to artesunate and rosuvastain alone ( 69 ).…”

Section: Chm As Potential Drug Therapy For Aaamentioning

confidence: 99%

Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm

Seto

Chang

Kiat

et al. 2018

Front. Cardiovasc. Med.

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Abdominal aortic aneurysm (AAA) is an irreversible condition where the abdominal aorta is dilated leading to potentially fatal consequence of aortic rupture. Multiple mechanisms are involved in the development and progression of AAA, including chronic inflammation, oxidative stress, vascular smooth muscle (VSMC) apoptosis, immune cell infiltration and extracellular matrix (ECM) degradation. Currently surgical therapies, including minimally invasive endovascular aneurysm repair (EVAR), are the only viable interventions for AAAs. However, these treatments are not appropriate for the majority of AAAs, which measure <50 mm. Substantial effort has been invested to identify and develop pharmaceutical treatments such as statins and doxycycline for this potentially lethal condition but these interventions failed to offer a cure or to retard the progression of AAA. Chinese herbal medicine (CHM) has been used for the management of cardiovascular diseases for thousands of years in China and other Asian countries. The unique multi-component and multi-target property of CHMs makes it a potentially ideal therapy for multifactorial diseases such as AAA. In this review, we review the current scientific evidence to support the use of CHMs for the treatment of AAA. Mechanisms of action underlying the effects of CHMs on AAA are also discussed.

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“…In den vergangenen Jahren wurde experimentell nachgewiesen, dass die Artemisinin-Aktivität nicht auf Malaria beschränkt ist und dass sie auch für verschiedene Erkrankungen, einschließlich Krebs, von therapeutischem Interesse ist [11,13,17,20,25].…”

Section: Merkeunclassified

Artemisinin und seine Derivate – eine neue Option für die Krebstherapie?

Naß

Efferth

2017

DZO

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ZusammenfassungArtemisinin und seine Derivate sind nicht nur hochwirksame Medikamente gegen Malaria. Zahlreiche präklinische und vorläufige klinische Daten deuten darauf hin, dass sie auch therapeutisches Potenzial für die Onkologie besitzen könnten. Artemisinin-basierte Medikamente induzieren oxidativen Stress und DNA-Schäden und hemmen die Angiogenese. Tumorzellen sterben durch diese Substanzen, indem sie verschiedene Formen des Zelltodes hervorrufen (Apoptose, Autophagie, Ferroptose). Zytostatika-resistente Tumorzellen werden durch Artemisinin und seine Derivate effektiv abgetötet. Artemisinin-Derivate zeigen mit verschiedenen Standard-Krebsmedikamenten, Radiotherapie und therapeutischen Antikörpern additive bis synergistische Therapieeffekte gegenüber Tumorzelllinien. Ergebnisse aus klinischen Studien zeigten positive Ergebnisse, jedoch sollte bedacht werden, dass die behandelten Gruppen bisher nur klein waren. Individuelle Heilversuche sollten nur von approbierten Ärzten vorgenommen werden. Bis zur routinemäßigen klinischen Anwendung von Artemisinin und seinen Derivaten in der Krebstherapie wird sicherlich noch einige Zeit vergehen. Die bisherigen Ergebnisse sind jedoch vielversprechend.

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Artesunate attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through inhibition of pro-inflammatory cytokines and pro-inflammatory chemokines

Cited by 62 publications

References 26 publications

Dihydroartemisinin exerts multiple effects in ameliorating CNS inflammation by enhancing AXL signaling in microglia from mouse model of multiple sclerosis

Dihydroartemisinin exerts multiple effects in ameliorating CNS inflammation by enhancing AXL signaling in microglia from mouse model of multiple sclerosis

Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm

Artemisinin und seine Derivate – eine neue Option für die Krebstherapie?

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