Artesunate causes relaxation of rat aortic rings and reduces the contractile response to noradrenaline

Synthesis and structure–activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity

“…[7][8][9] The present widely used artemisin derivatives have vascular effects. 17 Artemisin causes relaxation of precontracted rat aortic rings which is partly mediated by NO. 17 When phenylephrine (PE, 3 Â 10 À7 M) was applied to thoracic aortic rings with endothelium after achieving a maximal response, cassiarin A 1 showed vasorelaxant actions at 3 Â 10 À5 M and…”

Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

“…The dose and concentration of artemisinin were defined according to a previous report 31 and the results of our preliminary experiments. All of the concentrations referred to in this study were the final concentrations in the Krebs-Henseleit solution in the chamber of the myograph.…”