Artesunate inhibits proliferation, migration, and invasion of thyroid cancer cells by regulating the PI3K/AKT/FKHR pathway

Xu, Zhiwei; Liu, Xiaojian; Zhuang, Daoping

doi:10.1139/bcb-2021-0275

Cited by 15 publications

(10 citation statements)

References 36 publications

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“…ART, a Chinese herbal medicine, regulates many cellular processes and has been proved to be a potent anticancer drug in many tumors has been proved (Jia et al 2023 ; Xu et al 2022 ; Li et al 2021 ). Studies found ART regulated Eph/ephrin signaling pathway in different cancers.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, studies have focused on the anticancer effects of Artesunate (ART) which is a derivative of artemisinin. ART can play a cancer-suppressing role in many tumors by promoting apoptosis, autophagy, inhibiting cell proliferation and angiogenesis, etc., such as lung cancer, thyroid cancer and colorectal cancer (Wang et al 2020a ; Xu et al 2022 ; Huang et al 2022 ). ART shows promise as an anticancer drug by inhibiting many classical pathways.…”

Section: Introductionmentioning

confidence: 99%

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Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway

Yao,

Ma,

et al. 2024

J Cancer Res Clin Oncol

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Purpose Choroidal melanoma (CM), a kind of malignant tumor, is the main type of Uveal melanoma and one half of CM patients develop metastases. As a member of Eph/ephrin pathway that plays vital role in tumors, EphrinA3 (EFNA3) has been proved to promote tumorigenesis in many tumors. But the effect of EFNA3 in CM has not been studied yet. Through inhibiting angiogenesis, inducing apoptosis and autophagy and so on, Artesunate (ART) plays a key anti-tumor role in many tumors, including CM. However, the exact mechanisms of anti-tumor in CM remain unclear. Methods The UALCAN and TIMER v2.0 database analyzed the role of EFNA3 in CM patients. Quantitative real time polymerase chain reaction (qPCR) and Western blot were used to detect the expression of EFNA3 in CM. The growth ability of CM was tested by clonogenic assay and Cell counting kit-8 assay, and the migration ability using Transwell assay. Results Our results found EFNA3 boosted CM cells’ growth and migration through activating Stat3/Akt signaling pathway, while ART inhibited the tumor promoting effect of CM via downregulating EFNA3. In xenograft tumor model, EFNA3 knockdown and ART significantly inhibited tumor growth. Conclusion EFNA3 could be a valuable prognostic factor in CM. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway

Yao,

Ma,

et al. 2024

J Cancer Res Clin Oncol

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“…Reference [132] found strong anti-proliferative effects of ARS in medullary thyroid carcinoma cells and in chemo resistant anaplastic thyroid cancer [133]. It inhibited proliferation, migration, and invasion by targeting the P13K/AKT pathway [134].…”

Section: O Thyroid Carcinomamentioning

confidence: 99%

Is Artesunate the Best Partner of Gemcitabine in Pancreatic Cancer?

Koltai

2022

CLINICMED

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Pancreatic adenocarcinoma (PDAC) is still one of the most malignant and difficult to treat cancers. The therapeutic protocols in use, such as gemcitabine, gemcitabine associated with nab-paclitaxel and/or cisplatin or the FOLFIRINOX scheme have added very little to PDAC outcome. It is clear by now, that none of them can do the job alone. The more than 3,300 trials registered in clinicaltrials.gov is the best proof that research has not yet found an adequate response to tackle this disease. Thus, an innovative search is badly needed. As part of this investigation we came across a phytotherapeutic product that has been very successful for the treatment of falciparum- and vivax- caused malaria: artemisinin derivatives. These derivatives showed very low toxicity for humans and have been tested in millions of patients with paludism. Interestingly, they have also shown important anti-cancer properties. Regarding PDAC in particular there is strong evidence supporting not only an additive effect to gemcitabine without a concomitant increase in human toxicity, but also decreased resistance. This mini-review will discuss the evidence showing that artemisinin derivatives can be the best possible association with gemcitabine for PDAC chemotherapeutic treatment.

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“…It has been repurposed as an anticancer drug because it induces multiple forms of PCD, including apoptosis, autophagy, and ferroptosis . ART induces apoptosis and inhibits the proliferation and migration of thyroid cancer cells by inhibiting the PI3K/AKT/FKHR signaling pathway . However, whether ART induces ferroptosis in PTC cells and improves PTC therapy remains elusive.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Ferroptotic and Antitumor Effect of Free or Liposome-Encapsulated Artesunate in Papillary Thyroid Cancer Cells

Sun,

Zheng,

Zhou

et al. 2024

ACS Omega

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Papillary thyroid cancer (PTC) is generally treated as an indolent and curable cancer. However, the unavailability of surgery and ineffective radiotherapy persists in PTCs, resulting in poor outcomes and low survival rates. Thus, new chemotherapeutic strategies for PTCs are urgently needed. Resistance to ferroptosis remarkably contributes to cancer occurrence and progression. Artesunate (ART) has been repurposed as an anticancer drug, as it induces cell death in numerous cancers. However, whether ART induces ferroptosis in PTC cells and, consequently, facilitates PTC therapy remains elusive. Furthermore, overcoming the pharmacological limitations of ART is a key requirement to support its clinical application. Herein, we reanalyzed the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression database (GTEx) to characterize the occurrence of resistance to ferroptosis in thyroid cancer. In vitro results showed that ART induced ferroptosis in PTC cells by increasing the cellular iron content. The encapsulation of ART by liposomes did not alter the efficiency in inducing ferroptosis and inhibiting the invasion and migration of PTC cells compared with direct ART application. Thus, PTC resistance to ferroptosis can be overcome by ART and liposomeencapsulated ART.

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Artesunate inhibits proliferation, migration, and invasion of thyroid cancer cells by regulating the PI3K/AKT/FKHR pathway

Cited by 15 publications

References 36 publications

Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway

Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway

Is Artesunate the Best Partner of Gemcitabine in Pancreatic Cancer?

In Vitro Ferroptotic and Antitumor Effect of Free or Liposome-Encapsulated Artesunate in Papillary Thyroid Cancer Cells

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