Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway

Ma, Qing-yue; Xu, Xiao-yan; Zhu, Yuan-zhang; Yao, Ning-ning; Liu, Yi-chong; Gao, Xiao-di; Zhang, Qian; Luo, Wen-juan

doi:10.1016/j.acthis.2024.152174

Acta Histochemica

2024

DOI: 10.1016/j.acthis.2024.152174

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Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway

Qing-yue Ma,

Xiao-yan Xu,

Yuan-zhang Zhu

et al.

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Anti-tumor mechanism of artesunate

Fan,

Yan,

et al. 2024

Front. Pharmacol.

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Artesunate (ART) is a classic antimalarial drug with high efficiency, low toxicity and tolerance. It has been shown to be safe and has good anti-tumor effect. Existing clinical studies have shown that the anti-tumor mechanisms of ART mainly include inducing apoptosis and autophagy of tumor cells, affecting tumor microenvironment, regulating immune response, overcoming drug resistance, as well as inhibiting tumor cell proliferation, migration, invasion, and angiogenesis. ART has been proven to fight against lung cancer, hepatocarcinoma, lymphoma, multiple myeloma, leukemia, colorectal cancer, ovarian cancer, cervical cancer, malignant melanoma, oral squamous cell carcinoma, bladder cancer, prostate cancer and other neoplasms. In this review, we highlight the effects of ART on various tumors with an emphasis on its anti-tumor mechanism, which is helpful to propose the potential research directions of ART and expand its clinical application.

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Anti-tumor mechanism of artesunate

Fan,

Yan,

et al. 2024

Front. Pharmacol.

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Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway

Cited by 1 publication

References 24 publications

Anti-tumor mechanism of artesunate

Anti-tumor mechanism of artesunate

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