Arthralgia resolution rate following chikungunya virus infection

Abstract

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The clinical manifestation and the influence of age and comorbidities on long-term chikungunya disease and health-related quality of life: a 60-month prospective cohort study in Curaçao

“…Moreover, almost half of the affected patients reported joint weakness in the upper and lower extremities, and 82.3% reported moderate to severe pain intensity. In addition, although not the main focus of our study, our findings supports the results of a recent review [34], reporting that the prevalence of long-term arthralgia induced by the Asian CHIKV genotype is not lower compared to the IOL CHIKV genotype, as have been previously reported [1]. In contrast, even though a higher proportion of patients self-declared being affected by the IOL CHIKV genotype 5 years after disease onset, a lower arthralgia prevalence of 22% was reported, and yet a similar proportion of patients reported moderate to severe pain intensity compared to our study [35].…”

“…The use of questionnaires and the lack of objective physical assessment may have led to an overestimation of symptoms on the patient's part. However, patient's threshold for reporting symptoms like arthralgia and joint weakness may be lower compared to the threshold of the clinician for verifying a symptom like joint swelling, that may be visually present on physical examinations [34,45]. In addition, the cohort was not tested for intercurrent dengue infection.…”

Seroepidemiological Reconstruction of Long-term Chikungunya Virus Circulation in Burkina Faso and Gabon

“…Infection by CHIKV is associated with acute onset of fever, joint pain, headache, muscle pain, and rash [ 1–4 ]. It can also result in severe chronic arthralgia that can last for months or even years [ 5 , 6 ]. Initially identified in Tanzania in 1952, autochthonous transmission of CHIKV has now been recorded in 6 continents with recent large-scale epidemics in Asia and the Americas [ 7 , 8 ].…”

Results of a nationally representative seroprevalence survey of chikungunya virus in Bangladesh

“…The clinical presentation of chikungunya in humans is similar to that of dengue and a range of other illnesses, so is often misdiagnosed [2,[5][6][7][8][9]. Around half of infected individuals suffer long-term effects, the most common of which is arthralgia [10][11][12][13][14][15] that can continue for months or even years post-infection, severely decreasing quality of life [16][17][18]. High attack rates coupled with frequent severe, persistent symptoms means that CHIKV outbreaks can place a large burden on communities, especially in lower-middle-income countries [2].…”