Arthritis and hypertension in patients with systemic lupus erythematosus

Kaplan, David S.; Ginzler, Ellen M.; Feldman, Joseph

doi:10.1002/art.1780350411

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…No correlation was found between the development of non-musculoskeletal systemic symptoms or the presence of lupus nephritis and the presence of JUS abnormalities, as previously suggested by Kaplan et al. 17 The latter research group suggested that SLE patients with arthritis were less likely to develop nephritis than those without it. We found all lupus nephritis patients ( n = 3) within the control group.…”

Section: Discussionsupporting

confidence: 56%

Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients

Corzo

Salman-Monte

Torrente-Segarra

et al. 2016

Lupus

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Objective To describe long-term clinical and serological outcome in all systemic lupus erythematosus (SLE) domains in SLE patients with hand arthralgia (HA) and joint ultrasound (JUS) inflammatory abnormalities, and to compare them with asymptomatic SLE patients with normal JUS. Methods SLE patients with HA who presented JUS inflammatory abnormalities ('cases') and SLE patients without HA who did not exhibit JUS abnormalities at baseline ('controls') were included. All SLE clinical and serological domain involvement data were collected. End follow-up clinical activity and damage scores (systemic lupus erythematosus disease activity index (SLEDAI), Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR)) were recorded. JUS inflammatory abnormalities were defined based on the Proceedings of the Seventh International Consensus Conference on Outcome Measures in Rheumatology Clinical Trials (OMERACT-7) definitions. Statistical analyses were carried out to compare 'cases' and 'controls'. Results A total of 35 patients were recruited. The 'cases', n = 18/35, had a higher incidence of musculoskeletal involvement (arthralgia and/or arthritis) through the follow-up period (38.9% vs 0%, p = 0.008) and received more hydroxychloroquine (61.1% vs 25.0%, p = 0.034) and methotrexate (27.8% vs 0%, p = 0.046) compared to 'controls', n = 17/35. Other comparisons did not reveal any statistical differences. Conclusions We found SLE patients with arthralgia who presented JUS inflammatory abnormalities received more hydroxychloroquine and methotrexate, mainly due to persistent musculoskeletal involvement over time. JUS appears to be a useful technique for predicting worse musculoskeletal outcome in SLE patients.

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Section: Discussionsupporting

confidence: 56%

Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients

Corzo

Salman-Monte

Torrente-Segarra

et al. 2016

Lupus

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“…Several well-established, general cardiovascular risk factors such as hypertension, high low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol are known to be present in SLE and contribute, in part, to the increased cardiovascular risk (6,7).…”

Section: Introductionmentioning

confidence: 99%

A pilot study on the effects of exercise in patients with systemic lupus erythematosus

Ramsey‐Goldman

Dunlop³

et al. 2000

Arthritis & Rheumatism

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Objective. A pilot study was designed to assess the efficacy and safety of different exercise therapies on patient-reported fatigue and functional status.Methods. Ten patients with systemic lupus erythematosus (SLE) were randomly placed in either an aerobic exercise group (group 1: n ϭ 5) or a range of motion/muscle strengthening (ROM/MS) exercise group (group 2: n ϭ 5). Outcome measures assessed at baseline and the end of the study were fatigue, functional status, disease activity, cardiovascular fitness, isometric strength, bone mineral density (BMD) of the lumbar spine and femoral neck, and parathyroid hormone and osteocalcin as representative bone biochemical markers for bone resorption and bone formation, respectively. Results. Both aerobic and ROM/MS types of exer-cise were safe and did not worsen SLE disease activity. Patients in both exercise groups showed some improvement in fatigue, functional status, cardiovascular fitness, and muscle strength. Both groups showed increased bone turnover, but BMD was unchanged. Eighty percent of the patients met the compliance standard for the study.Conclusions. This pilot study shows the feasibility of exercise for SLE patients. The potential value of this approach shows promise in the routine management of these patients.

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“…Jaccoud arthropathy is described in 2% to 35% of SLE patients. 31 Remarkably, Kaplan et al 32 described that in their sample the presence of persistent rheumatoid-like arthritis in patients with SLE identified a clinical subset of patients who are less likely to develop nephritis.…”

Section: Discussionmentioning

confidence: 99%

The lupus patient with positive rheumatoid factor

Fedrigo

Santos

Nisihara

et al. 2018

Lupus

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Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Epidemiological data (age, gender, age at disease onset, ethnic background and tobacco use), clinical data (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia, arthritis and hypothyroidism) and serological profile (anti-dsDNA, anti-Ro/SS-A, anti-La/SS-B, anti-RNP, anti-Sm, IgG aCL, IgM aCL, lupus anticoagulant, direct Coombs and RF) were collected. Patients with positive and negative RF were compared. Results RF was found in 24.9% of the sample. In univariate analysis, RF was positively associated with butterfly rash ( p = 0.04), anti-Ro ( p = 0.03), anti-Sm antibodies ( p = 0.01) and hypothyroidism ( p = 0.01) and negatively associated with glomerulonephritis ( p = 0.003). Logistic regression showed that only glomerulonephritis ( p = 0.03; OR = 0.45; 95% CI = 0.21-0.93) and anti-Ro ( p = 0.009; OR = 2.3; 95% CI = 1.24-4.57) were independent associations. Conclusion In our sample RF was associated with protection from glomerulonephritis and with higher prevalence of anti-Ro antibodies.

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Arthritis and hypertension in patients with systemic lupus erythematosus

Cited by 9 publications

References 20 publications

Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients

Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients

A pilot study on the effects of exercise in patients with systemic lupus erythematosus

The lupus patient with positive rheumatoid factor

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