Arthritis as a Disease of Aging and Changes in Antioxidant Status

Saxena, Rahul

doi:10.1016/b978-0-12-405933-7.00005-6

Cited by 15 publications

(11 citation statements)

References 43 publications

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“…1,6,14 In this context, depletion in total antioxidant activity (TAA) indicates the disturbance in the antioxidant defense system of the body, which could be responsible for the initiation of disease development with senescence. In the present study, plasma TAA levels were found to be significantly low (p<0.05) in OA subjects which could be explained on the basis of contributory effect of reduced enzymic and non-enzymic antioxidant levels, due to augmented oxidative stress in OA.…”

Section: Discussionmentioning

confidence: 99%

“…Amusingly, alteration in antioxidant defense system in knee osteoarthritis patients and in older population has been well documented. 1,6 However to best of our knowledge; this is the first study addressing the relation of oxidative stress mediated electrolyte imbalance in knee OA elderly patients to predict future HT risk. Therefore, the overall objectives of present study were to ascertain the marker of oxidative stress and serum minerals (Na…”

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confidence: 99%

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Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach

2015

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Background: Osteoarthritis (OA), also known as degenerative arthritis, is the leading cause of chronic disability in elderly. Although, it is a process of progressive deterioration of articular cartilage with ageing which involves numerous risk factors, it is conceivable that oxidative stress mediated electrolyte imbalance may have a crucial role in the development of hypertension risk in OA elderly. Aims & objective: The present study was designed to assess the association of oxidative stress and altered serum electrolyte levels in OA elderly patients and to determine their effect in predicting hypertension (HT) risk. Methods: Total antioxidant activity (TAA), lipid peroxidation (malondialdehyde; MDA) and serum mineral (Na+, K+, Mg2+ and Ca2+) levels were estimated in 40 OA elderly patients by using standard methods and statistically compared it with that of 40 healthy normal individuals of same age group (55-70 years). Result: Plasma TAA, serum potassium, magnesium and calcium levels were significantly low in patient group (p<0.05) as compared to healthy controls whereas erythrocyte MDA levels were significantly high in OA subjects. However, serum sodium levels were increased insignificantly (p<0.1) in OA subjects. Conclusion: Our findings indicate that oxidative stress plays a significant role in shaping the OA older population to develop future hypertension, characterized by altered serum minerals levels. Therefore, consumption of diet rich in antioxidants, proteins and minerals with low dietary salt should be increased with senescence in order to prevent disease complexity.DOI: http://dx.doi.org/10.3126/ajms.v6i5.12274 Asian Journal of Medical Sciences Vol.6(5) 2015 26-30

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach

2015

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“…12 Superoxide anion, which is believed to be one of the initiators of free radical mediated pathological alterations (such as cartilage degradation, synovitis and lipid peroxidation) leading to arthritic complication, is efficiently removed by antioxidant enzyme SOD. 1 In the present study, we observed that the SOD activity in active RA patients was significantly low (P<0.001) as compared to healthy controls, which direct towards its protective and superoxide radical scavenging action in active RA patients. Our findings were in concordance with the findings of Karatas et al According to them, reduced activity of SOD could be the result of inter and intramolecular cross-linking of proteins and thereby causing conformational changes in SOD which leads to accumulation of H 2 O 2 followed by induction of lipid peroxidation leading disease progression.…”

Section: Discussionmentioning

confidence: 68%

“…1 Previous evidences suggest that reactive oxygen species derived from molecular oxygen (Superoxide anion, hydrogen peroxide and hydroxyl radical) contribute to the tissue injury, which accompanies inflammatory disorders including rheumatoid arthritis and osteoarthritis. 2,3 A number of sources of free radical generation have been identified in biological tissues, which may be mutually interactive and once triggered, they may lead to loss of antioxidant defense system.…”

Section: Introductionmentioning

confidence: 99%

Cumulative effect of systemic inflammation and oxidative stress in 40 known cases of active rheumatoid arthritis

et al. 2015

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Background: Oxidative stress has been implicated in the pathophysiology of a number of diseases such as cancer, hypertension and inflammatory diseases. Although previous evidences provided extensive literature about the biological role of antioxidant enzymes in rheumatoid arthritis (RA), there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes along with marker of systemic inflammation in RA. The objective of present study was to estimate the level of C-reactive protein (CRP), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSHPx) and Ceruloplasmin in active RA patients.Methods: 40 patients of either sex (30-50 years age group) suffering from active RA and 40 normal healthy individuals served as control; were included in the study. Above mentioned parameters were estimated using standard methods and data from patients and controls were compared by using Student’s t-test.Results: Erythrocyte SOD, CAT and GSHPx activity were significantly low in RA subjects (P<0.001) whereas plasma Ceruloplasmin level was found to be significantly high (P<0.001) as compared to healthy controls.Conclusions: These findings suggest that combined effect of inflammation and free radical generation is involved in the pathogenesis of active RA, characterized by imbalance in antioxidant enzyme status and enhanced CRP levels, which served as an excellent marker of oxidative stress and systemic inflammation in active RA.

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“…Additional features present include malaise, tiredness and night pain (Miossec & Tebib 2006, Dubey & Adebajo 2008, Orhan et al 2013. Prevalance of RA is 0.5-1% from population of world and increases at age 40 until 70 years (Saxena et al 2014, Wahl & Schuna 2014.…”

Section: Introductionmentioning

confidence: 99%

The Potency of Alpha Lipoic Acid as Anti Inflammatory on the Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rat Model

Megawati¹,

Rahmadi²,

Susilo³

et al. 2017

FMI

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Arthritis as a Disease of Aging and Changes in Antioxidant Status

Cited by 15 publications

References 43 publications

Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach

Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach

Cumulative effect of systemic inflammation and oxidative stress in 40 known cases of active rheumatoid arthritis

The Potency of Alpha Lipoic Acid as Anti Inflammatory on the Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rat Model

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