Arthritis-induced increase in cholecystokinin release in the rat anterior cingulate cortex is reversed by diclofenac

Heilborn, Umut; Rost, Benjamin R.; Arborelius, Lotta; Brodin, Ernst

doi:10.1016/j.brainres.2006.12.006

Cited by 11 publications

(7 citation statements)

References 72 publications

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“…[218] Microdialysis coupled with RIA was chosen for monitoring CCK levels in rat brain regions like the anterior cingulate cortex (ACC). [219, 220] It was found that at the time when the animals are known to show pain-related behavior, CCK release is elevated in the ACC in awake rats.…”

Section: Neuropeptidesmentioning

confidence: 99%

Review of recent advances in analytical techniques for the determination of neurotransmitters

Perry

Kennedy

2009

Analytica Chimica Acta

333

221

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Methods and advances for monitoring neurotransmitters in vivo or for tissue analysis of neurotransmitters over the last five years are reviewed. The review is organized primarily by neurotransmitter type. Transmitter and related compounds may be monitored by either in vivo sampling coupled to analytical methods or implanted sensors. Sampling is primarily performed using microdialysis, but low-flow push-pull perfusion may offer advantages of spatial resolution while minimizing the tissue disruption associated with higher flow rates. Analytical techniques coupled to these sampling methods include liquid chromatography, capillary electrophoresis, enzyme assays, sensors, and mass spectrometry. Methods for the detection of amino acid, monoamine, neuropeptide, acetylcholine, nucleoside, and soluable gas neurotransmitters have been developed and improved upon. Advances in the speed and sensitivity of these methods have enabled improvements in temporal resolution and increased the number of compounds detectable. Similar advances have enabled improved detection at tissue samples, with a substantial emphasis on single cell and other small samples. Sensors provide excellent temporal and spatial resolution for in vivo monitoring. Advances in application to catecholamines, indoleamines, and amino acids have been prominent. Improvements in stability, sensitivity, and selectivity of the sensors have been of paramount interest.

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Section: Neuropeptidesmentioning

confidence: 99%

Review of recent advances in analytical techniques for the determination of neurotransmitters

Perry

Kennedy

2009

Analytica Chimica Acta

333

221

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show abstract

“…These data demonstrate a central role of endogenous opioid receptor ligands in ACC regulation of sensory and affective components of the pain experience, mainly via mu-opioid receptors. Additionally, the neuropeptide cholecystokinin (CCK) is especially abundant in the ACC, and the non-selective cyclooxygenase inhibitor diclofenac reversed the increase of CCK release in carrageenan-induced monoarthritic rats [39,40] . Because CCK has been implicated in anxiety, this result indicates that an altered CCK-ergic activity in the ACC may be of importance for the affective component of pain [39,40] .…”

Section: Neurotransmitter and Receptor Mechanisms Underlying Acc Invomentioning

confidence: 99%

“…Additionally, the neuropeptide cholecystokinin (CCK) is especially abundant in the ACC, and the non-selective cyclooxygenase inhibitor diclofenac reversed the increase of CCK release in carrageenan-induced monoarthritic rats [39,40] . Because CCK has been implicated in anxiety, this result indicates that an altered CCK-ergic activity in the ACC may be of importance for the affective component of pain [39,40] . The presence of taurine, an inhibitory amino acid, in the ACC also decreased autotomy behavior in one neuropathic pain model, and this effect was blocked by the glycine receptor antagonist strychnine, suggesting an interaction effect of the glycine receptor with taurine in the ACC [41] .…”

Section: Neurotransmitter and Receptor Mechanisms Underlying Acc Invomentioning

confidence: 99%

Cerebral cortex modulation of pain

2008

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Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional components mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SΙ) and secondary somatosensory (SΠ) cortices, the ventrolateral orbital cortex and the motor cortex. These cortical structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaqueductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be involved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.

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“…In the present study, the hot plate temperature was tuned on 54 ± 0.1°C and to prevent the tissue injury, 30 s cut-off was considered for this test. [ 16 17 ]…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac

Peyghambari

Mh²,

Rozabadi

et al. 2015

Adv Biomed Res

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Backgrounds:In Persian traditional medicine, palm date spathe (PDS) is introduced as an analgesic. Therefore, this study was designed to investigate the analgesic effect of hydroalcoholic extract of PDS on acute and chronic pain in mice in comparison with diclofenac and morphine.Materials and Methods:In this study, which was conducted in summer 2014, 220 male mice (20–30 g) were randomly divided into two categories, each consists of 11 groups as follows: A normal control group, a solvent (Tween 80) control group, 3 morphine positive control groups (2, 4 and 8 mg/kg), 3 diclofenac positive control groups (10, 20 and 30 mg/kg), and 3 main experimental PDS groups (2, 20, and 200 mg/kg). Hot plate was applied on animals in one category and writing test on the other category to assess acute and chronic pain, respectively.Results:In the writing test, the average writing time and number of animals receiving a maximum dosage of morphine, diclofenac, and PDS were significantly less than the control group. In the hot plate test, only groups receiving different doses of morphine at different time points and those received 30 mg/kg diclofenac at 15 min after the intervention showed significant difference with the control group.Conclusion:200 mg/kg extract of PDS, revealed a significant analgesic effect on chronic pain, but it did not show any analgesic effect on acute pain.

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Arthritis-induced increase in cholecystokinin release in the rat anterior cingulate cortex is reversed by diclofenac

Cited by 11 publications

References 72 publications

Review of recent advances in analytical techniques for the determination of neurotransmitters

Review of recent advances in analytical techniques for the determination of neurotransmitters

Cerebral cortex modulation of pain

Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac

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