Arthropod-Borne Bacterial Diseases in Pregnancy

Dotters‐Katz, Sarah K.; Kuller, Jeffrey A.; Heine, R. Phillips

doi:10.1097/ogx.0b013e3182a5ed46

Cited by 66 publications

(8 citation statements)

References 140 publications

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“…TBRF infection during pregnancy is associated with an increased risk of death in pregnant women [46,47]. Infections during pregnancy are claimed to cause up to 10-15% of neonatal deaths worldwide and a perinatal lethality of up to 43.6% has been reported [1,23,44,[48][49][50].…”

Section: Treatment Jarisch-herxheimer Reaction (Jhr) and Outcomementioning

confidence: 99%

Tick borne relapsing fever - a systematic review and analysis of the literature

et al. 2022

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Tick borne relapsing fever (TBRF) is a zoonosis caused by various Borrelia species transmitted to humans by both soft-bodied and (more recently recognized) hard-bodied ticks. In recent years, molecular diagnostic techniques have allowed to extend our knowledge on the global epidemiological picture of this neglected disease. Nevertheless, due to the patchy occurrence of the disease and the lack of large clinical studies, the knowledge on several clinical aspects of the disease remains limited. In order to shed light on some of these aspects, we have systematically reviewed the literature on TBRF and summarized the existing data on epidemiology and clinical aspects of the disease. Publications were identified by using a predefined search strategy on electronic databases and a subsequent review of the reference lists of the obtained publications. All publications reporting patients with a confirmed diagnosis of TBRF published in English, French, Italian, German, and Hungarian were included. Maps showing the epidemiogeographic mosaic of the different TBRF Borrelia species were compiled and data on clinical aspects of TBRF were analysed. The epidemiogeographic mosaic of TBRF is complex and still continues to evolve. Ticks harbouring TBRF Borrelia have been reported worldwide, with the exception of Antarctica and Australia. Although only molecular diagnostic methods allow for species identification, microscopy remains the diagnostic gold standard in most clinical settings. The most suggestive symptom in TBRF is the eponymous relapsing fever (present in 100% of the cases). Thrombocytopenia is the most suggestive laboratory finding in TBRF. Neurological complications are frequent in TBRF. Treatment is with beta-lactams, tetracyclines or macrolids. The risk of Jarisch-Herxheimer reaction (JHR) appears to be lower in TBRF (19.3%) compared to louse-borne relapsing fever (LBRF) (55.8%). The overall case fatality rate of TBRF (6.5%) and LBRF (4–10.2%) appears to not differ. Unlike LBRF, where perinatal fatalities are primarily attributable to abortion, TBRF-related perinatal fatalities appear to primarily affect newborns.

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Section: Treatment Jarisch-herxheimer Reaction (Jhr) and Outcomementioning

confidence: 99%

Tick borne relapsing fever - a systematic review and analysis of the literature

et al. 2022

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“…1,13,14 Doxycycline for 7 days is the treatment of choice for RMSF, including in pregnant patients with life-threatening disease and in children. 4,7,8,15,16 Tetracycline can also be used.…”

Section: Treatment Of Rocky Mountain Spotted Fevermentioning

confidence: 99%

“…Chloramphenicol is an alternative treatment for pregnant patients with mild to moderate disease or those patients with a severe hypersensitivity reaction to doxycycline. 1,4,7,9,15,16 In the United States, chloramphenicol is currently available only in an intravenous formulation.…”

Section: Treatment Of Rocky Mountain Spotted Fevermentioning

confidence: 99%

Tickborne diseases other than Lyme in the United States

Eickhoff

Blaylock

2017

CCJM

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Tickborne diseases are increasing in the United States, and the geographic range of tick vectors is expanding. Tickborne diseases are challenging to diagnose, as they present with vague symptoms such as fever, constitutional symptoms, and nonspecific laboratory abnormalities. A high degree of clinical suspicion is required to make a diagnosis, as patients often do not recall a tick bite. The availability of laboratory testing for tickborne diseases is limited, especially in the acute setting. Therefore, if a tickborne disease is suspected, empiric therapy should often be initiated before laboratory confirmation of the disease is available. This article summarizes the most common non-Lyme tickborne diseases in the United States.

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“…Other commonly associated symptoms include myalgia, arthralgia, abdominal pain, and neurologic symptoms. The case fatality rate for highly virulent strains of R. prowazekii is 2 to 30% (Azad, ; Dotters‐Katz et al, ). No cases of R. prowazekii were identified in the literature among pregnant women.…”

Section: Introductionmentioning

confidence: 99%

“…However, in other rickettsial infections, specifically tick‐borne rickettsial disease, as well as with other biological threat agents, tetracyclines are used during pregnancy, specifically in life‐threatening situations (Chapman et al, ). According to one set of authors, chloramphenicol is considered the preferred treatment for R. prowazekii during pregnancy (Dotters‐Katz et al, ), however, administration of chloramphenicol during the third trimester of pregnancy can be associated with a risk of grey baby syndrome, an accumulation of toxic metabolites of this drug in newborns (Meaney–Delman et al ).…”

Section: Introductionmentioning

confidence: 99%

Preparing for biological threats: Addressing the needs of pregnant women

Watson

Ellington

Nelson

et al. 2017

Birth Defects Research

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Intentional release of infectious agents and biological weapons to cause illness and death has the potential to greatly impact pregnant women and their fetuses. We review what is known about the maternal and fetal effects of seven biological threats: Bacillus anthracis (anthrax); variola virus (smallpox); Clostridium botulinum toxin (botulism); Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis); Yersinia pestis (plague); Francisella tularensis (tularemia); and Rickettsia prowazekii (typhus). Evaluating the potential maternal, fetal, and infant consequences of an intentional release of an infectious agent requires an assessment of several key issues: (1) are pregnant women more susceptible to infection or illness compared to the general population?; (2) are pregnant women at increased risk for severe illness, morbidity, and mortality compared to the general population?; (3) does infection or illness during pregnancy place women, the fetus, or the infant at increased risk for adverse outcomes and how does this affect clinical management?; and (4) are the medical countermeasures recommended for the general population safe and effective during pregnancy? These issues help frame national guidance for the care of pregnant women during an intentional release of a biological threat. Birth Defects Research 109:391-398, 2017.© 2017 Wiley Periodicals, Inc.

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Arthropod-Borne Bacterial Diseases in Pregnancy

Cited by 66 publications

References 140 publications

Tick borne relapsing fever - a systematic review and analysis of the literature

Tick borne relapsing fever - a systematic review and analysis of the literature

Tickborne diseases other than Lyme in the United States

Preparing for biological threats: Addressing the needs of pregnant women

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