Arthropods

Weisbroth, Steven H.

doi:10.1016/b978-0-12-262502-2.50028-6

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Epizootiology1

B Parasitology1

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1994

2015

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Cited by 5 publications

(2 citation statements)

References 45 publications

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“…d. Acariasis (Mite Infestation) (Weisbroth, 1982) Several species of mites infest laboratory mice. They include Myobia musculi, Radfordia affinis, Myocoptes musculinus and, less commonly, Psorergates simplex.…”

Section: Epizootiologymentioning

confidence: 99%

Biology and Diseases of Mice

Jacoby¹,

Fox²,

Davisson³

2002

Laboratory Animal Medicine

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Section: Epizootiologymentioning

confidence: 99%

Biology and Diseases of Mice

Jacoby¹,

Fox²,

Davisson³

2002

Laboratory Animal Medicine

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“…Low-power dissecting microscopy is used to inspect the pelage and skin of laboratory animal carcasses for mites and lice, and the macerated gastrointestinal tract for adult helminths (Flynn, 1973;Weisbroth, 1982). Microscopic examination of skin scrapings may be necessary to detect mites, such as Demodex and Notoedres, which burrow into the epidermis (Weisbroth, 1979a;Wescott, 1982).…”

Section: B Parasitologymentioning

confidence: 99%

Microbiological Quality Control for Laboratory Rodents and Lagomorphs

Shek

Smith

Pritchett-Corning

2015

Laboratory Animal Medicine

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Immune Complex Vasculitis with Secondary Ulcerative Dermatitis in Aged C57BL/6NNia Mice

et al. 1994

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A spontaneous, severely pruritic ulcerative dermatitis was initially observed in 33/201 (16.4%) aged C57BL/6NNia mice obtained from the National Institute of Aging. This ulcerative dermatitis also developed in 21/98 (21%) aged C57BL/6 mice in a subsequent experimental group obtained from the same source. The average age of onset in the initial group was 20 months. These animals were negative for ectoparasite infestation and primary bacterial or fungal infection. The lesions varied from acute epidermal excoriation and ulceration to chronic ulceration with marked dermal fibrosis. In the affected animals, leukocytoclastic vasculitis was present in the dermis in both areas of ulceration and areas covered by normal intact epidermis. Immunofluorescent staining of the skin was positive for deposition of IgG, IgM, and fibrinogen in the dermal vessels of the affected mice. Leukocytoclastic vasculitis was not observed in unaffected animals, nor were deposits of immunoglobulin or fibrinogen present in the skin of the control animals. This study provides strong evidence that the ulcerative dermatitis is caused by an immune complex-induced vasculitis. The elucidation of the pathogenesis of this disease is important because of the significant percentage of animals affected and because the C57BL/6 mouse may be a useful model to study human vasculitides.

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Arthropods

Cited by 5 publications

References 45 publications

Biology and Diseases of Mice

Biology and Diseases of Mice

Microbiological Quality Control for Laboratory Rodents and Lagomorphs

Immune Complex Vasculitis with Secondary Ulcerative Dermatitis in Aged C57BL/6NNia Mice

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