Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: A 2- to 5-year follow-up study

Abstract

Level IV, therapeutic, case series (no, or historical, control group).

Osteochondral autografting (mosaicplasty) in grade IV cartilage defects in the knee joint: 2- to 7-year results

“…Chow et al [20], in their study of 30 knees, performed second-look arthroscopy in eight patients without symptoms and found a correlation between the clinical result and second-look arthroscopy. Marcacci et al [15] did second-look arthroscopy in five patients which showed good coverage and integration at the short-term follow-up.…”

“…Kish et al [13] treated 52 athletes with the same technique and after a minimum one year follow-up stated that 63% of the patients had returned to full sport participation. Chow et al [20], in a study with 30 patients, carried out arthroscopic mosaicplasty for osteochondral lesions sized 1-2.5 cm 2 and with a minimum two year follow-up found 83.3% excellent and good outcome. Marcacci et al [15], in a study of 37 patients, concluded that mosaicplasty was a safe and satisfactory technique at the short-and medium-term follow-up.…”

“…This makes it easier to handle comorbidities such as ACL tears. Chow et al [20] simultaneously performed two ACL reconstructions in 30 patients with mosaicplasties. Marcacci et al [15] performed mosaicplasty in association with 12 ACL reconstructions during the same operation.…”

“…An interface that consists of fluid-like signal intensity suggests that integration between the repair tissue and the native cartilage is incomplete and a fissure may exist. Chow et al [20], in their study of 30 patients, used MRI to examine 12 patients and found that congruency was restored in 11 (91.7%) patients without signs of fissuring or delamination, but they found an abnormal marrow signal in the subchondral bone beneath the region of cartilage repair, even four years after the procedure. Jakob et al [22] evaluated 52 patients with MRI after mosaicplasty and noted bony integration of osteochondral plugs and continuity of joint surface curvature, but they did not mention the MRI results of all patients.…”

The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

“…Autologous osteochondral transplantation gained popularity for the treatment of articular cartilage injuries following successful experiments and clinical results [2,5,11,18]. Our study suggests that FGF-2 accelerates the integration of the graft and the host in articular cartilage defects in an animal model.…”