Arthroscopic evidence of cartilage regeneration in severe knee cartilage defects and osteoarthritis following treatment with allogeneic umbilical cord-derived mesenchymal stromal cells (Chondrocell-Ex)

Yusoff, B. Md; Ramlan, M.; Chin, S.; Mohamad, Nabishah; Cheong, Soon-Keng; Noor, Misbah; Don, Andrew; Fadilah, S A W

doi:10.1016/j.jcyt.2019.03.517

Cited by 2 publications

(1 citation statement)

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“…The structure of the knee joint is more complex, with the upper femur and the lower tibial plateau, as well as the overlying ligament muscle tissue, so the degenerative changes of the muscles around the knee joint will cause corresponding changes in the knee joint structure. Studies have shown that people lose 1% to 3% of their muscle strength every day without exercise [ 7 ]. In elderly people over the age of 65 years, because they have retired and rarely take part in physical activity, this will exacerbate the changes brought about by this degenerative muscle loss.…”

Section: Osteoarticular Cartilage Regenerationmentioning

confidence: 99%

Stem Cells Promote the Regeneration of Knee Joint Degenerative Bone and Articular Cartilage

Zheng

2022

Journal of Healthcare Engineering

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Cartilage damage has a certain ability to spontaneously repair, but the repaired tissue often shows the phenomenon of cartilage terminal differentiation, which causes irreversible damage to its structure and function and seriously affects the quality of life and work of patients. It is of great significance to study the problems encountered in the process of cartilage damage repair. This article mainly studied stem cells to promote the regeneration of knee joint degenerative bone articular cartilage. First, the animal articular cartilage defect is modeled, 10 ml of animal venous blood is drawn, 0.5 ml of PRP is collected by centrifugation, mixed with cartilage fragments, and transplanted into the defect area into a gel. In the BMSCs group, 1 ml of BMSCs with a cell concentration of 107 cells/ml was injected intra-articularly. The histological chromosomes were observed after 6 weeks and 12 weeks, and the effect of cartilage tissue repair was analyzed and evaluated, and the related data were statistically analyzed. We evaluated the spontaneous repair ability of partial cartilage damage, full-thickness cartilage damage, and osteochondral damage. Furthermore, for partial cartilage damage repair, by using the cartilage damage in vitro model and biomaterials to simulate the in vivo microenvironment, the adhesion and cell morphology on the surface of partial- and full-thickness cartilage damage were evaluated, and the experiments were further used to evaluate the exogenous and internal induced migration effect of source on cultured cells in vitro. In the cell concentration study, the cartilage repair effect increased with the increase in concentration within a certain range, and the tissue repair ability remained stable when the concentration exceeded 107 cells/ml. Using ECM-oriented scaffolds to compound autologous BMSCs, tissue-engineered cartilage was successfully constructed, which had the histological and biochemical characteristics of normal cartilage tissue, and better repaired the damaged articular cartilage of large animals.

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Section: Osteoarticular Cartilage Regenerationmentioning

confidence: 99%